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81.
营养不良患者乳头体的神经病理研究与临床观察 总被引:1,自引:0,他引:1
目的探讨营养不良患者乳头体的病理改变与临床表现的关系。方法选择8例营养不良患者和6例无营养不良患者的尸检脑组织标本,作乳头体、海马、颞叶、额叶、扣带回、小脑上蚓、齿状核和基底节的光镜检查,并结合患者的临床资料。结果营养不良患者中枢神经系统有多种病理改变,乳头体的病理改变为神经细胞缺血性改变7例,神经细胞脱失4例,间质水肿7例,血管增生4例,胶质增生7例。临床表现为嗜睡、昏迷。乳头体的病理改变与营养不良病程长短有关。结论营养不良患者中枢神经系统有多种病理改变,乳头体的病理改变与临床的意识障碍密切相关。 相似文献
82.
KELLY HOWARD BSc PhD ERIC LO B MED SCI SUZETTE SHEPPARD BSc ROBYN STARGATT PhD MAPS 《Paediatric anaesthesia》2010,20(10):913-923
Background: Past research examining the psychosocial impact of general anesthesia and day case surgery on children has been hampered by a lack of valid and reliable assessment tools. Aim: The purpose of the current study was to assess the feasibility of using a well‐validated scale (i.e. the Pediatric Quality of Life Inventory Generic Core Scales Version 4.0, PedsQL) in the perioperative setting and to establish changes seen in a sample of children having day case surgery when using this scale. Method: Eighty‐nine children (aged 3–12 years) scheduled for general anesthesia for day case tonsillectomy or ear tube insertions were recruited into a prospective study in Melbourne, Australia. Parents completed the PedsQL and the Post Hospitalization Behavioral Questionnaire (PHBQ), and children completed the PedsQL (child self‐report) at baseline (preanesthesia), 7 days following anesthesia and 30 days following anesthesia. Results: The response rate at day 7 and day 30 was modest but when returned the PedsQL and PHBQ had minimal missing data. On the PedsQL, parents rated children’s physical functioning as worse at day 7 than at baseline but psychosocial functioning did not differ significantly from baseline. At 30 days, both physical and psychosocial functioning was rated by parents to be better than baseline levels. From children’s perspective, there was little evidence of a change in their physical or psychosocial functioning on the self‐report PedsQL at day 7, but by day 30 both physical and psychosocial functioning was above baseline levels. A similar pattern was observed on the PHBQ, with little difference in ratings of behavioral problems between baseline and day 7, but less behavioral problems reported at day 30 compared with baseline. Conclusions: The PedsQL is feasible for use in the perioperative setting. Future studies should take into account the possibility that deterioration of psychosocial functioning is uncommon at 1 ‐month postsurgery compared to the preoperative baseline. 相似文献
83.
CHAN Ngai-yin CHOY Chi-chung CHEUNG Kar-chun LAU Chun-leung LO Ying-keung CHU Pui-shan YUEN Ho-chuen LAU Suet-ting CHOI Yuen-choi 《中华医学杂志(英文版)》2010,123(13):1645-1651
Background Cardiac resynchronization therapy (CRT) is an effective electrical therapy for patients with moderate to severe heart failure and cardiac dyssynchrony. This study aimed to investigate the degree of acute left ventricular (LV) resynchronization with biventricular pacing (BVP) at different LV sites and to examine the feasibility of performing transthoracic echocardiography (TTE) to quantify acute LV resynchronization during CRT procedure. Methods Fourteen patients with NYHA Class Ⅲ-Ⅳ heart failure, LV ejection fraction 〈35%, QRS duration 〉120 ms and septal-lateral delay (SLD) 〉60 ms on tissue Doppler imaging (TDI), underwent CRT implant. TDI was obtained from three apical views during BVP at each accessible LV site and SLD during BVP was derived. Synchronicity gain index (Sg) by SLD was defined as (I+(SLD at baseline - SLD at BVP)/SLD at baseline). Results Seventy-two sites were studied. Positive resynchronization (R+, Sg〉1) was found in 42 (58%) sites. R+ was more likely in posterior or lateral than anterior LV sites (66% vs. 36%, P 〈0.001). Concordance of empirical LV lead implantation sites and sites with R+ was 50% (7/14). Conclusions The degree of acute LV resynchronizaUon by BVP depends on LV lead location and empirical implantation of LV lead results in only 50% concordance with R+. Performing l-rE during CRT implantation is feasible to identify LV sites with positive resynchronization. 相似文献
84.
目的:探讨气管、支气管内特殊异物的临床特点及治疗方法。方法:回顾性分析自1998年9月以来收治的789例儿童气管、支气管异物病历资料,从发病率、患者性别、年龄、病程、临床症状、辅助检查、治疗方法、异物的解剖位置、异物种类及诊疗效果等方面对其中的23例特殊异物的临床特点及治疗方法进行总结。结果:22例痊愈出院,1例死亡。结论:气管、支气管内特殊异物在临床特点及治疗方法等方面均不完全等同于普通异物。 相似文献
85.
KAZUYOSHI SUENARI M.D. YENN‐JIANG LIN M.D. SHIH‐LIN CHANG M.D. LI‐WEI LO M.D. YU‐FENG HU M.D. SHIH‐ANN CHEN M.D. 《Pacing and clinical electrophysiology : PACE》2010,33(10):e100-e101
We report a case of focal atrial tachycardia (AT) originating from prior superior vena cava isolation line. The P‐wave morphology in lead aVL during the AT differed from that during sinus rhythm although their foci were in close proximity to each other. We discuss the mechanism based on the activation maps of the right atrium. (PACE 2010; 33:e100–e101) 相似文献
86.
In order to explore which amino acids or which blocks of amino acids in the 29 amino acid neuropeptide galanin are important for recognition of the endogenous ligand by galanin receptor subtypes present in the jejunum and in the hypothalamus, respectively, we have carried out L-Ala substitutions of individual amino acids or of blocks of amino acids in the rat galanin sequence and examined the binding of the obtained analogs to the rat hypothalamic and jejunal galanin receptor subtypes. This study reveals that the galanin sequence YLLGPH9–14 is essential for recognition of galanin by both the rat hypothalamic and jejunal galanin receptor subtypes. Substitution of the N-terminal amino acids, GWTL1–4, leads to total loss of affinity of galanin for both hypothalamic and jejunal galanin receptors. The α-helical C-terminal amino acid (25–29) part of galanin has no greater influence on the affinity of galanin to the hypothalamic galanin receptor subtype. L-Ala substitution of the C-terminal amino acids of galanin KHGLT25–29 shows, however, that this C-terminal motif is essential for the recognition by the jejunal galanin receptor subtype, whereas amino acids in the middle portion of galanin NSAG5–8 are of importance for binding to the hypothalamic but not to the jejunal receptor. [Ala5–8] Galanin thus has a more than 100-fold higher affinity to jejunal receptor than to the hypothalamic receptor, while [Ala25–29] galanin has a more than 100-fold higher affinity for the hypothalamic than for jejunal galanin receptor subtypes. pH dependence of the galanin binding to these receptor subtypes is also different. © Munksgaard 1997. 相似文献
87.
88.
MD Pavlovi DM Karadagli LO Kandolf P Mijukovi 《Journal of the European Academy of Dermatology and Venereology》2001,15(1):54-58
Three cases of persistent erythema multiforme, two of unknown aetiology and one precipitated by influenza are reported. Lesions were widespread, mostly atypical in appearance and regressed in response to immunosuppressants (systemic steroids and/or azathioprine) or, in one case, to dapsone. One patient developed erythroderma responding eventually to etretinate. Histology in all patients was consistent with the mixed, epidermodermal pattern of erythema multiforme. There were no significant laboratory abnormalities nor marked symptomatology apart from itching. The persistent form appears to belong to the spectrum of erythema multiforme being heterogeneous with respect to inducing stimuli, including viral antigens, neoplastic or inflammatory disease or unknown causes. Whenever it is possible, treatment should be adjusted depending on the causative agent. 相似文献
89.
L O Orafidiya 《The Journal of pharmacy and pharmacology》1989,41(5):341-342
Volatile solvents may evaporate during cone/plate viscometry so that false rheograms develop. This surface evaporation was prevented in a cod-liver oil-in-water emulsion stabilized with zanthoxylum gum by layering a film of cod-liver oil on the exposed surface of the emulsion test sample. The oil layer effectively prevented evaporation and did not alter significantly the rheological behaviour of the test material. 相似文献
90.
CHEW-WUN WU SHYH-HAW TSAY MAO-CHIH HSIEH SU-SHUN LO WING-YIU LUI FANG-KU P'ENG 《Journal of gastroenterology and hepatology》1996,11(11):1083-1088
The present study sought to evaluate the clinicopathological features of our gastric cancer patients in terms of a modified Lauren's histological classification and compared the results with those from studies from Japan and Western countries. A total of 536 consecutive patients with gastric cancer were treated surgically between December 1987 and December 1993. A clinicopathological analysis was only performed for intestinal types (IT) and diffuse types (DT) of gastric cancer because patients falling into the ‘other’ category were too small to produce meaningful data. Of 536 cases of gastric cancer, 268 (50%) were IT, 231 (43.1%) were DT and 37 (6.9%) were of the other type. The overall IT:DT ratio was 1.2. Gastric cancer patients with IT (in contrast to DT) were characterized by older age, male dominance, smaller tumours, the tumour often being located in the lower and upper third of the stomach and less peritoneal metastasis. In both sexes, the peak incidence of gastric cancer patients was in the age group 65–74 years. Men had higher proportions of IT carcinoma than women. The IT:DT ratio for men and women was 1.4 and 0.4, respectively. Although the increased ratio of IT:DT paralleled the advance of age in both sexes, the transitional age (the age at which the IT:DT ratio exceeds 1.0) in male patients (age group 51–64 years) was earlier than for female patients (age group 65–74 years). Patients with IT gastric cancer had a significantly better survival rate than those with DT. However, the type of carcinoma (IT or DT) was not an independent predictor of survival. These data indicate that gastric cancer in Taiwan Chinese has different biological behaviour in terms of IT and DT. The clinicopathological features in IT and DT carcinoma are similar to studies from Japan and from Western countries. 相似文献