Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid

The recent finding that retinoic acid induces terminal granulocytic differentiation of the human promyelocytic leukemia cell line, HL-60, prompted an investigation of the sensitivity to this inducer of human myelocytic leukemia cells in primary suspension culture. Of the 21 leukemic specimens, only cells from the two patients with acute promyelocytic leukemia differentiated in response to retinoic acid. After an incubation period of 5--7 days in 1 microM retinoic acid, the cells from these two patients showed extensive morphological and functional maturation. Thus, because it appears that retinoic acid specifically induces granulocytic differentiation of leukemic promyelocytes, this compound may have therapeutic utility in the treatment of acute promyelocytic leukemia.     

双源CT在诊断冠状动脉病变中的准确性

目的:本研究以有创性冠状动脉造影为诊断标准,分别以患者和冠状动脉节段为单位评价双源CT在诊断冠状动脉病变中的价值。方法:确诊或疑诊为冠状动脉病变的35例患者进行了双源CT和X线冠状动脉造影检查。CT扫描参数:扫描机架旋转时间0.33s(时间分辨力83ms),球管电压120kV,球管电流