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41.
João Batista Cesar‐Neto PhD Josué Martos PhD Luciano Artifon DDS Luiz Fernando Machado Silveira PhD Douver Michelon DDS PhD Alexandre Severo Masotti PhD José Carlos Maciel Silva MS 《Journal of prosthodontics》2012,21(8):626-630
The aim of this clinical report is to describe the successful treatment of a mandibular first molar presenting an extensive fracture at the buccal aspect in a young patient. The extension of the fracture was a negative prognostic factor for tooth maintenance. An alternative clinical treatment was proposed since the patient was young and presented with good oral hygiene and periodontal health. The treatment was based on orthodontic forced eruption associated with odontoplasty. A 3‐year follow‐up after the surgical procedure demonstrated the maintenance of periodontal health and good plaque control. It can be concluded that orthodontic forced eruption associated with odontoplasty promoted favorable conditions for prosthetic rehabilitation and is a feasible procedure in the treatment of tooth fracture extended below the cementoenamel junction. 相似文献
42.
Overweight,obese, underweight,and frequency of sugar consumption as risk indicators for early childhood caries in Brazilian preschool children 下载免费PDF全文
Cecilia Claudia Costa Ribeiro Mariana Carvalho Batista da Silva Ana Margarida Melo Nunes Erika Bárbara de Abreu Fonseca Thomaz Cadidja Dayane Sousa Carmo Marizélia Rodrigues Costa Ribeiro Antônio Augusto Moura da Silva 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2017,27(6):532-539
43.
44.
Thaís Batista de Carvalho Teresa Cristina Goulart Oliveira-Sequeira Semíramis Guimar?es 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(1):43-47
The quest for new antiparasitic alternatives has led researchers to base
their studies on insights into biology, host-parasite interactions and pathogenesis.
In this context, proteases and their inhibitors are focused, respectively, as
druggable targets and new therapy alternatives. Herein, we proposed to evaluate the
in vitro effect of the cysteine protease inhibitor E-64 on
Giardia trophozoites growth, adherence and viability.
Trophozoites (105) were exposed to E-64 at different final concentrations,
for 24, 48 and 72 h at 37 °C. In the growth and adherence assays, the number of
trophozoites was estimated microscopically in a haemocytometer, whereas cell
viability was evaluated by a dye-reduction assay using MTT. The E-64 inhibitor showed
effect on growth, adherence and viability of trophozoites, however, its better
performance was detected in the 100 µM-treated cultures. Although metronidazole was
more effective, the E-64 was shown to be able to inhibit growth, adherence and
viability rates by ≥ 50%. These results reveal that E-64 can interfere in some
crucial processes to the parasite survival and they open perspectives for future
investigations in order to confirm the real antigiardial potential of the protease
inhibitors. 相似文献
45.
George João Ferreira do Nascimento Danielle de Albuquerque Pires Rocha Hébel Cavalcanti Galvão Antônio de Lisboa Lopes Costa Lélia Batista de Souza 《Clinical oral investigations》2011,15(3):329-335
The benign peripheral nerve sheath tumours are rare lesions mainly represented by schwannoma and neurofibroma. The present
work evaluated the clinical and histopathological features of schwannomas and neurofibromas of the oral cavity diagnosed in
a Brazilian population. Among 9.000 cases of oral lesions archived from 1970 to 2008, four schwannomas and 12 neurofibromas
were identified, microscopically revised and immunohistochemically certified through a panel including monoclonal antibodies
(anti-S100, vimentin, HHF-35 and desmin). From biopsy and histological sections records, clinical and histopathological data
were retrieved, reviewed and statistically analysed. Predominantly, schwannomas affected non-white males (3:1), with an age
and size averages of 34.7 years and 2.8 cm, respectively. Neurofibromas preferentially occurred on the gingival/alveolar ridge
of white females (5:1), with 35.7-year mean age, peak of incidence between 3rd and 5th decade, and size average of 1.7 cm.
(12 cases, 75%). The studied tumours exhibited more frequently as a painless, sessile and slow growth very similar to other
oral lesions, but their microscopic features differed significantly. Schwannomas and neurofibromas are extremely uncommon
in the oral cavity, exhibiting clinical features very similar but specific and peculiar microscopic findings that are useful
in the establishment of the diagnosis, which in some particular cases must be confirmed by immunohistochemistry. 相似文献
46.
47.
Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine 总被引:2,自引:0,他引:2
Epinephrine causes platelet aggregation and secretion by interacting with alpha 2-adrenergic receptors on the platelet surface. Platelet aggregation requires the binding of fibrinogen to a specific receptor on the membrane glycoprotein IIb-IIIa complex. Although the IIb-IIIa complex is identifiable on the surface of resting platelets, the fibrinogen receptor is expressed only after platelet activation. The current studies were designed to examine the effect of occupancy of platelet alpha 2-adrenergic receptors by epinephrine on the expression of fibrinogen receptors and on the aggregation of platelets. The ability of epinephrine to induce the expression of fibrinogen receptors was studied under two different conditions: acute stimulation (less than 1 min) and prolonged stimulation (50 to 90 min), the latter of which is associated with a reduction or "desensitization" of the platelet aggregation response. Expression of the fibrinogen receptor was monitored with 125I-fibrinogen as well as with 125I-PAC-1 (PAC-1), a monoclonal antibody that binds to the glycoprotein IIb-IIIa complex only after platelets are activated. Epinephrine caused an immediate increase in PAC-1 and fibrinogen binding that was dependent on occupancy of the alpha 2-receptor by epinephrine and on the presence of extracellular free Ca (KCa = 30 mumol/L). By itself, 1 mmol/L Mg was unable to support induction of the fibrinogen receptor by epinephrine. However, it did decrease the Ca requirement by about two orders of magnitude. Prolonged stimulation of unstirred platelets by epinephrine led to a 70% decrease in the aggregation response when the platelets were subsequently stirred. Despite their decreased aggregation response, desensitized platelets bound PAC-1 and fibrinogen normally, indicating that the loss of aggregation was not due simply to a decrease in fibrinogen receptor expression. Although desensitization was not affected by pretreatment of the platelets with aspirin, it was partially prevented when extracellular Ca was chelated by EDTA during the long incubation with epinephrine. These studies demonstrate that once platelet alpha 2-adrenergic receptors are occupied by epinephrine, extracellular Ca is involved in initiating the aggregation response by supporting the induction of the fibrinogen receptor and the binding of fibrinogen. Furthermore. Ca-dependent reactions subsequent to fibrinogen binding may be necessary for maximal platelet aggregation and are impaired when platelets become desensitized to epinephrine. 相似文献
48.
Ribeiro MG Salerno T Mattos-Guaraldi AL Camello TC Langoni H Siqueira AK Paes AC Fernandes MC Lara GH 《Revista do Instituto de Medicina Tropical de S?o Paulo》2008,50(3):177-185
Phenotypic characteristics, antimicrobial susceptibility profile, and clinical-epidemiological features of 28 Nocardia strains isolated from 19 cases of bovine mastitis, eight cutaneous-subcutaneous lesions and one case of pneumonia in dogs were evaluated. Microbiological, biochemical, cytological and scanning electron microscopy methods were used in diagnosis. Nocardia asteroides type IV, Nocardia otitidiscaviarum,Nocardia nova (type III) and Nocardia farcinica (type V) were isolated from bovine milk, bronchial lavage and/or cutaneous-subcutaneous abscesses in dogs. Nocardial bovine mastitis was diagnosed predominantly in clinical cases, in dairy herds with poor environmental hygienic conditions between milking and inappropriate intramammary therapy. Canine nocardiosis was observed commonly in animals co-infected with distemper virus. Sulphamethoxazole-trimethoprim (92.8%), amikacin (92.8%) and ceftiofur (92.8%) were the most effective drugs in 28 isolates. Multiple drug resistance to three or more and five or more antimicrobials was observed in ten (35.7%) and three (10.7%) strains, respectively, predominantly with use of cloxaxillin, cefoperazone and ampicillin. The species (type) classification, clinical-epidemiological characteristics, diagnosis, multiple-drug resistance and public health considerations in Nocardia strains isolated from cattle and dogs in Brazil are discussed, with special reference to report of bovine mastitis by N. otitidiscaviarum by first time in Brazil and the similarity between Nocardia species isolated from human and animal origin. 相似文献
49.
Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholesterol content, cholesterol/phospholipid ratio, and the lymphocyte subpopulations. This article confirms previous reports on the efficacy of chlorambucil in this setting and describes some morphological, and biochemical concomitant events. 相似文献
50.
Dallago CM Abech DD Pereira-Lima JF Leães CG Batista RL Trarbach EB Oliveira Mda C 《Pituitary》2008,11(1):109-112
Kallmann syndrome (KS) is a developmental disease characterized by the association of isolated hypogonadotropic hypogonadism
and anosmia/hyposmia. We report an unusual presentation of two females with KS and empty sella. These females, aged at 20
and 29-year-old, presented primary amenorrhea with prepubertal estradiol and low gonadotropin levels. No other significant
clinical signs were observed. Empty sella was observed on MRI in both cases. Sequencing of FGFR1 gene, recently implicated in autosomal form of KS, was performed and one splicing mutation (IVS14 + 1G > A) was identified
in one patient. 相似文献