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21.
22.
Dubin-Johnson综合征是一种先天性非溶血性黄疸,在临床中较罕见,需与其他原因所导致的黄疸相鉴别.本文报告了我院1例Dubin- Johnson综合征的诊治情况,有助于加深对该病的认识. 相似文献
23.
自体骨髓干细胞移植治疗失代偿期肝硬化 总被引:12,自引:2,他引:12
选择36例失代偿期肝硬化患者,年龄37~59岁,患者在无菌条件下,从髂后上棘抽取骨髓100~200mL,在体外分离纯化骨髓干细胞后,局部麻醉下经股动脉插管经肝动脉将分离的骨髓干细胞移植于肝脏。自移植后12周,25例(69.4%)患者谷丙转氨酶逐渐降低,由平均(2788.56±357.90)nkat/L降至(1077.05±440.25)nkat/L;22例(61.1%)患者总胆红素逐渐下降,由平均(151.47±25.77)μmol/L降至(69.93±18.86)μmol/L;27例(75%)患者白蛋白逐渐升高,由平均(25.17±11.79)g/L升至(30.87±12.17)g/L。在干细胞移植后凝血酶原活动度逐渐上升,由术前平均(25.89±12.67)%上升至术后12周的(50.39±19.38)%,患者凝血机制明显改善。移植后大多数患者身体状况有明显的改善;移植后12周腹水减轻的19例(52.7%),食欲改善的28例(77.7%),体力好转20例(58.3%),腹胀减轻17例(47.2%),36例干细胞移植患者未出现严重并发症。 相似文献
24.
Michelle J Hunt Elizabeth LC Salisbury Dorothy M Painter Stephen Lee 《The Australasian journal of dermatology》1996,37(4):196-198
A 56-year-old male presented with a pruritic, generalized vesiculobullous eruption. His past history revealed classical symptoms of limited Hailey-Hailey disease for 34 years. Clinically, vesicles, bullae and occasional pustules were present and multiple biopsies confirmed this to be an unusual presentation of Hailey-Hailey disease. Various therapeutic modalities including topical and oral antibiotics, oral prednisone and dapsone failed to achieve sustained remission. Treatment with lowdose oral etretinate (25 mg daily) produced marked clinical improvement with complete suppression of new vesicle formation after 6 weeks. 相似文献
25.
26.
The metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-
tetrakisphosphate in homogenates and sub-fractions from normal rat liver
and premalignant liver nodules was investigated. The activities of
5-phosphatase, expressed as pmol converted substrate per minute and mg
protein, were equal when using the two substrates, and did not differ
between normal and nodular homogenates. Subcellular fractions were purified
by sequential steps of differential centrifugation and density gradient
fractionation procedures. The total phosphatase activity was found to be
distributed between cytosol (15%) and membraneous fractions (75%), with
most of the enzyme activity residing in the plasma membranes. A doubling of
phosphatase specific activity was seen in the nodular low density membrane
fraction, containing Golgi apparatus and endosomes, as compared with normal
liver. Inositol 1,4,5- trisphosphate 3-kinase activity was found to be
exclusively cytosolic. No difference in this enzyme was seen between the
two tissue types studied. Vasopressin (0.2 or 2 microM) had no effect
either on phosphatase or kinase activity. The compartmentalization of
inositol polyphosphate 5-phosphatase activity presents a possible
explanation of earlier findings that premalignant liver tissue was able to
respond with inositol 1,4,5-trisphosphate, but not inositol 1,3,4,5-
tetrakisphosphate formation after agonist stimulation.
相似文献
27.
A postal survey of recently appointed consultant paediatricians was undertaken to determine whether they perceived their training had adequately equipped them for their current job. The response rate was 69% (207/299). After excluding replies from consultants trained outside the UK the analysis was carried out on 167 replies. Trainees held a mean 5.2 posts during general and higher professional training, necessitating a mean 1.8 house moves. Altogether 82% felt moves were beneficial to training but 46% found moves 'very disruptive' to family life. Only 12% of district general hospital and 22% of teaching hospital senior registrars took two research sessions a week. Supervision and training in research was absent or poor for more than 60%; 24% felt major changes and 55% moderate changes were needed to current training. Training in non-clinical skills was particularly in demand and a curriculum for both trainers and trainees with regular appraisals is required. Research at senior registrar level needs review and educational methods improved to achieve better training in a shorter period. 相似文献
28.
Computed tomography of the infratemporal fossa 总被引:2,自引:0,他引:2
29.
Data obtained on 426 consecutive patients referred to a breast center by 122 physicians, including family practitioners, general surgeons, and other specialists, showed that the obstetricians-gynecologists referred the greatest average number of patients per physician, with more than 50% of these referrals for screening mammography. Internists referred fewer patients by nearly a factor of ten, with only one-third of these patients referred for screening mammography. Internists may be the weakest link in the utilization of screening mammography. 相似文献
30.
Forty-one proved cases of acute acalculous cholecystitis imaged with technetium-99m iminodiacetic acid (IDA) cholescintigraphy were retrospectively analyzed. After the exclusion of one indeterminate scan (showing poor initial hepatic uptake and excretion), the study yielded a 92.5% (37 of 40) sensitivity for the detection of cystic or common bile duct obstruction. Each of the three patients with false-negative scintigrams had other abnormal scintigraphic findings suggestive of biliary tract disease. Of the 20 patients (48.8%) with focal or diffuse gangrenous cholecystitis or perforation, seven (35%) exhibited either free peritoneal spill or increased pericholecystic activity to indicate the presence of advanced disease. 相似文献