全文获取类型
收费全文 | 1668641篇 |
免费 | 125732篇 |
国内免费 | 23876篇 |
专业分类
耳鼻咽喉 | 19445篇 |
儿科学 | 48907篇 |
妇产科学 | 40560篇 |
基础医学 | 238396篇 |
口腔科学 | 40410篇 |
临床医学 | 171055篇 |
内科学 | 310861篇 |
皮肤病学 | 28931篇 |
神经病学 | 134323篇 |
特种医学 | 61392篇 |
外国民族医学 | 564篇 |
外科学 | 223002篇 |
综合类 | 72426篇 |
现状与发展 | 75篇 |
一般理论 | 484篇 |
预防医学 | 136658篇 |
眼科学 | 37754篇 |
药学 | 130190篇 |
302篇 | |
中国医学 | 18560篇 |
肿瘤学 | 103954篇 |
出版年
2022年 | 13049篇 |
2021年 | 24557篇 |
2020年 | 17245篇 |
2019年 | 20602篇 |
2018年 | 35390篇 |
2017年 | 28532篇 |
2016年 | 30752篇 |
2015年 | 27295篇 |
2014年 | 35495篇 |
2013年 | 44306篇 |
2012年 | 64851篇 |
2011年 | 76375篇 |
2010年 | 46780篇 |
2009年 | 39933篇 |
2008年 | 64818篇 |
2007年 | 69477篇 |
2006年 | 58322篇 |
2005年 | 58758篇 |
2004年 | 51698篇 |
2003年 | 50309篇 |
2002年 | 46823篇 |
2001年 | 66116篇 |
2000年 | 68732篇 |
1999年 | 59065篇 |
1998年 | 19239篇 |
1997年 | 18057篇 |
1996年 | 16831篇 |
1995年 | 16062篇 |
1994年 | 14625篇 |
1993年 | 12962篇 |
1992年 | 43657篇 |
1991年 | 42519篇 |
1990年 | 40966篇 |
1989年 | 38624篇 |
1988年 | 35677篇 |
1987年 | 34613篇 |
1986年 | 32839篇 |
1985年 | 31227篇 |
1984年 | 23374篇 |
1983年 | 19826篇 |
1982年 | 11909篇 |
1979年 | 20974篇 |
1978年 | 14876篇 |
1977年 | 12082篇 |
1976年 | 11941篇 |
1975年 | 12111篇 |
1974年 | 14827篇 |
1973年 | 14481篇 |
1972年 | 13356篇 |
1971年 | 12418篇 |
排序方式: 共有10000条查询结果,搜索用时 156 毫秒
21.
Syed M. Gilani Muhammad Khan Andrea Barbieri Manju L. Prasad 《Diagnostic Histopathology》2021,27(6):263-271
Anaplastic thyroid carcinoma (ATC) is an aggressive thyroid malignancy with high mortality rate. This malignancy arises in thyroid follicular cells either denovo or with an associated differentiated thyroid carcinoma component. Clinically, it usually presents as a rapidly enlarging mass, pain and locally compressive symptoms. Histopathologic variability and heterogeneity often pose diagnostic challenges, especially in scant and paucicellular specimens. This article describes the clinical, histopathologic and molecular features of ATC and also addresses the associated diagnostic limitations and challenges. 相似文献
22.
23.
Qian Zhang Larry D. Mesner Gina M. Calabrese Naomi Dirckx Zhu Li Angela Verardo Qian Yang Robert J. Tower Marie-Claude Faugere Charles R. Farber Thomas L. Clemens 《The Journal of clinical investigation》2021,131(7)
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds of loci influencing BMD, but few have been functionally analyzed. In this study, we show that SNPs within a BMD locus on chromosome 14q32.32 alter splicing and expression of PAR-1a/microtubule affinity regulating kinase 3 (MARK3), a conserved serine/threonine kinase known to regulate bioenergetics, cell division, and polarity. Mice lacking Mark3 either globally or selectively in osteoblasts have increased bone mass at maturity. RNA profiling from Mark3-deficient osteoblasts suggested changes in the expression of components of the Notch signaling pathway. Mark3-deficient osteoblasts exhibited greater matrix mineralization compared with controls that was accompanied by reduced Jag1/Hes1 expression and diminished downstream JNK signaling. Overexpression of Jag1 in Mark3-deficient osteoblasts both in vitro and in vivo normalized mineralization capacity and bone mass, respectively. Together, these findings reveal a mechanism whereby genetically regulated alterations in Mark3 expression perturb cell signaling in osteoblasts to influence bone mass. 相似文献
24.
25.
Hannah C. Nordhues Anjali Bhagra Natya N. Stroud Jennifer A. Vencill Carol L. Kuhle 《Mayo Clinic proceedings. Mayo Clinic》2021,96(7):1907-1920
The coronavirus disease 2019 (COVID-19) pandemic has rapidly created widespread impacts on global health and the economy. Data suggest that women are less susceptible to severe illness. However, sex-disaggregated data are incomplete, leaving room for misinterpretation, and focusing only on biologic sex underestimates the gendered impact of the pandemic on women. This narrative review summarizes what is known about gender disparities during the COVID-19 pandemic and the economic, domestic, and health burdens along with overlapping vulnerabilities related to the pandemic. In addition, this review outlines recommended strategies that advocacy groups, community leaders, and policymakers should implement to mitigate the widening gender disparities related to COVID-19. 相似文献
26.
27.
28.
Heather L. Brown 《Journal of emergency nursing》2021,47(2):321-325
The coronavirus 2019 pandemic has affected almost every aspect of health care delivery in the United States, and the emergency medicine system has been hit particularly hard while dealing with this public health crisis. In an unprecedented time in our history, medical systems and clinicians have been asked to be creative, flexible, and innovative, all while continuing to uphold the important standards in the US health care system. To continue providing quality services to patients during this extraordinary time, care providers, organizations, administrators, and insurers have needed to alter longstanding models and procedures to respond to the dynamics of a pandemic. The Emergency Medicine Treatment and Active Labor Act of 1986, or EMTALA, is 1 example of where these alterations have allowed health care facilities and clinicians to continue their work of caring for patients while protecting both the patients and the clinicians themselves from infectious exposures at the same time. 相似文献
29.
30.
Background:We aim to evaluate the efficiency of Raman spectroscopy (RS) in diagnosing suspected patients with intrahepatic cholangiocarcinoma (ICC), manifested by diagnostic sensitivity, specificity, and accuracy.Methods:We will research widely the articles concerning the use of RS in ICC through authenticated database including PubMed/Medline, EMBASE, Web of Science, Ovid, Web of Knowledge, Cochrane Library, and CNKI between January 2012 and November 2020, retrieving at least 1500 spectra with strict criteria. This study will be carried out in accordance to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We are going to summarize the test performance using random effects models.Results:Based on the pooled sensitivity, specificity, and diagnostic accuracy, we intend to provide the relative diagnostic efficiency in ICC through RS.Conclusion:Through this systematic review and meta-analysis, we intend to provide the pooled sensitivity, specificity and diagnostic accuracy of RS in the diagnosis of suspected ICC. Other parameters like positive likelihood ratios (LR), negative LR, diagnostic odds ratio (DOR), and area under curve (AUC) of the summary receiver operating characteristics (SROC) curve will also be calculated and related figures will be drawn to help illustrate the efficacy of RS in the diagnosis of ICC. 相似文献