全文获取类型
收费全文 | 2341480篇 |
免费 | 174704篇 |
国内免费 | 5779篇 |
专业分类
耳鼻咽喉 | 32175篇 |
儿科学 | 77570篇 |
妇产科学 | 66866篇 |
基础医学 | 343603篇 |
口腔科学 | 65372篇 |
临床医学 | 215722篇 |
内科学 | 451909篇 |
皮肤病学 | 47878篇 |
神经病学 | 189512篇 |
特种医学 | 87804篇 |
外国民族医学 | 696篇 |
外科学 | 342138篇 |
综合类 | 51068篇 |
现状与发展 | 2篇 |
一般理论 | 729篇 |
预防医学 | 188475篇 |
眼科学 | 53209篇 |
药学 | 175980篇 |
7篇 | |
中国医学 | 5044篇 |
肿瘤学 | 126204篇 |
出版年
2018年 | 25208篇 |
2017年 | 18973篇 |
2016年 | 20978篇 |
2015年 | 24036篇 |
2014年 | 33178篇 |
2013年 | 51214篇 |
2012年 | 70244篇 |
2011年 | 74947篇 |
2010年 | 43943篇 |
2009年 | 40837篇 |
2008年 | 70247篇 |
2007年 | 74990篇 |
2006年 | 75786篇 |
2005年 | 73755篇 |
2004年 | 70570篇 |
2003年 | 67717篇 |
2002年 | 66178篇 |
2001年 | 103815篇 |
2000年 | 106500篇 |
1999年 | 90071篇 |
1998年 | 25961篇 |
1997年 | 23422篇 |
1996年 | 23362篇 |
1995年 | 22106篇 |
1994年 | 20838篇 |
1993年 | 19436篇 |
1992年 | 72426篇 |
1991年 | 71348篇 |
1990年 | 69690篇 |
1989年 | 67039篇 |
1988年 | 62266篇 |
1987年 | 60816篇 |
1986年 | 58137篇 |
1985年 | 55618篇 |
1984年 | 41779篇 |
1983年 | 35929篇 |
1982年 | 21685篇 |
1981年 | 19228篇 |
1979年 | 39017篇 |
1978年 | 27645篇 |
1977年 | 23317篇 |
1976年 | 22465篇 |
1975年 | 23854篇 |
1974年 | 28556篇 |
1973年 | 27843篇 |
1972年 | 26144篇 |
1971年 | 24263篇 |
1970年 | 22595篇 |
1969年 | 21277篇 |
1968年 | 20100篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
901.
A wound, in the broadest sense, is a disruption of normal anatomic structure and function. Acute wounds progress through a timely and orderly sequence of repair that leads to the restoration of functional integrity. In chronic wounds, this timely and orderly sequence goes awry. As a result, people with chronic wounds often face not only physiological difficulties but emotional ones as well. The study of body image and its damage as a result of a chronic wound fits well with Selder's transition theory. This article describes interviews with seven patients with chronic wounds. The themes that emerged from those interviews were compared with Selder's theory to describe patients' experience with chronic wounds as a transition process that can be identified and better understood by healthcare providers. 相似文献
902.
903.
K. Reynen U. Röber W.G. Daniel R. Henßge S. Schüler 《Clinical research in cardiology》1998,87(5):331-335
Zusammenfassung Zahlen zur H?ufigkeit von Herztumoren im operativen Krankengut liegen bisher für die Bundesrepublik Deutschland nicht vor.
Um einen entsprechenden überblick für das Jahr 1996 zu erhalten, wurde allen 77 herzchirurgischen Zentren der Bundesrepublik
Deutschland ein standardisierter Fragebogen zugesandt.
Daten von 65 der 77 Herzzentren (=84%) waren schlie?lich verfügbar: 187 Patienten waren wegen Myxomen, lediglich 44 wegen
nichtmyxomat?sen Tumoren, davon 28 wegen malignen prim?ren oder sekund?ren Herztumoren, operiert worden. Im Jahr 1996 waren
somit 0,32% (231/72 763) der Eingriffe mit Herz-Lungen-Maschine (erfa?t 72 763 von insgesamt 87 372) wegen eines Herztumors
vorgenommen worden. Ausgehend von diesen operativen Daten liegt die Inzidenz ausschlie?lich der prim?ren Tumoren des Herzens
zumindest bei 3 Tumoren pro 1 Million Einwohner pro Jahr (253 Tumoren/81,814 Millionen Einwohner). Wenn auch kleine Tumoren
asymptomatisch und unentdeckt bleiben k?nnen, wird heute doch die Mehrzahl prim?rer kardialer Tumoren durch Echokardiographie,
Computer- und Kernspintomographie bereits zu Lebzeiten des Patienten diagnostiziert, und diese Patienten werden in aller Regel
einer Operation zugeführt.
Somit werden gut 0,3% aller Eingriffe mit Herz-Lungen-Maschine in Deutschland wegen Herztumoren durchgeführt, wobei es sich
weit überwiegend um Myxome handelt.
Eingegangen: 23. September 1997, Akzeptiert: 11. Februar 1998 相似文献
904.
Changes on serial assessments of brain MRI lesion load are used for monitoring therapeutic efficacy in patients with multiple
sclerosis (MS). We assessed the accuracy and reliability of conventional spin-echo (CSE) and fast spin-echo (FSE) sequences
for measurement of lesion volume using a semiautomated contour technique. Cranial CSE and FSE examinations of 18 patients
with secondary progressive MS were studied. The mean lesion load was slightly higher with the CSE sequence (p = 0.002). Intraobserver
variability was significantly higher for FSE than for CSE, according to both the coefficient of variation between two measurements
(mean 2.48 % and 1.35 % respectively, p < 0.05) and back-transformed 95 % limits of agreement (1.005–1.060 for FSE; 0.988–1.019
for CSE). Although FSE sequences are quicker and the total lesion volume measurements are similar to those obtained with CSE,
the poorer reproducibility raises doubts about the use of FSE to replace CSE in clinical trials.
Received: 26 March 1996 Accepted: 4 April 1996 相似文献
905.
906.
采用荧光法测定负载Fura-2/AM大脑皮层突触体内游离钙「Ca^2+」i浓度大鼠感染性脑损伤中的变化及其意义。 相似文献
907.
908.
The 2.0-Å resolution crystal structure of a trimeric antibody fragment with noncognate VH–VL domain pairs shows a rearrangement of VH CDR3
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Xue Y. Pei Philipp Holliger Alexey G. Murzin Roger L. Williams 《Proceedings of the National Academy of Sciences of the United States of America》1997,94(18):9637-9642
The 2.0-Å resolution x-ray crystal structure of a novel trimeric antibody fragment, a “triabody,” has been determined. The trimer is made up of polypeptides constructed in a manner identical to that previously described for some “diabodies”: a VL domain directly fused to the C terminus of a VH domain—i.e., without any linker sequence. The trimer has three Fv heads with the polypeptides arranged in a cyclic, head-to-tail fashion. For the particular structure reported here, the polypeptide was constructed with a VH domain from one antibody fused to the VL domain from an unrelated antibody giving rise to “combinatorial” Fvs upon formation of the trimer. The structure shows that the exchange of the VL domain from antibody B1-8, a Vλ domain, with the VL domain from antibody NQ11, a Vκ domain, leads to a dramatic conformational change in the VH CDR3 loop of antibody B1-8. The magnitude of this change is similar to the largest of the conformational changes observed in antibody fragments in response to antigen binding. Combinatorial pairing of VH and VL domains constitutes a major component of antibody diversity. Conformationally flexible antigen-binding sites capable of adapting to the specific CDR3 loop context created upon VH–VL pairing may be employed by the immune system to maximize the structural diversity of the immune response. 相似文献
909.
Oral allergy syndrome induced by spinach 总被引:1,自引:1,他引:0
I. Sanchez F. Rodriguez J. L. Garcia-Abujeta L. Fernandez D. Quiñones D. Martin-Gil 《Allergy》1997,52(12):1245-1246
910.
AIMS: Immunohistological and molecular characterisation of a case of peripheral T-cell lymphoma (PTCL) of angioimmunoblastic T-cell lymphoma (AILD) type. METHODS: Frozen and paraffin wax sections of the diagnostic lymph node were stained with a panel of T- and B-cell lineage monoclonal antibodies. DNA was isolated from the paraffin wax embedded biopsy material for T-cell receptor (TCR) and immunoglobulin (Ig) PCR amplification, and resultant PCR products were cloned and sequenced. RESULTS: Immunohistological analysis of the presenting lymph node was consistent with an extensive infiltrate of pleomorphic CD3+CD8+ lymphocytes. Most (>80%) of these infiltrating CD3+ cells were also positive for the TCR VB5.1 gene family product, and were shown to be oligoclonal by TCRB PCR amplification and sequencing. Three oligoclones of B cells were also demonstrable by PCR amplification with Ig heavy chain primers and sequencing, a finding at variance with the diagnosis of AILD. CONCLUSIONS: These data demonstrate the complexity and heterogeneity of PTCL which require extensive histological examination and molecular characterisation. 相似文献