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排序方式: 共有8250条查询结果,搜索用时 187 毫秒
941.
Orlando G Wood KJ De Coppi P Baptista PM Binder KW Bitar KN Breuer C Burnett L Christ G Farney A Figliuzzi M Holmes JH Koch K Macchiarini P Mirmalek Sani SH Opara E Remuzzi A Rogers J Saul JM Seliktar D Shapira-Schweitzer K Smith T Solomon D Van Dyke M Yoo JJ Zhang Y Atala A Stratta RJ Soker S 《Annals of surgery》2012,255(5):867-880
The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues, or organs to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues, and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate. 相似文献
942.
Neonates with esophageal atresia and tracheoesophageal fistula usually present with inability to swallow immediately after birth often associated with respiratory distress. This is an unusual presentation of a very low-birth-weight neonate with a type C tracheoesophageal fistula that was fed for the first 4 days of life through an unintentional tracheogastric tube without incident. 相似文献
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944.
Lucas SM Sundaram CP Wolf JS Leveillee RJ Bird VG Aziz M Pautler SE Luke P Erdeljan P Baldwin DD Ebrahimi K Nadler RB Rebuck D Thomas R Lee BR Boylu U Figenshau RS Munver R Averch TD Gayed B Shalhav AL Gundeti MS Castle EP Anderson JK Duffey BG Landman J Okhunov Z Wong C Strom KH 《The Journal of urology》2012,187(2):522-527
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948.
Christopher W. Mastropietro Kyle Miletic Haiping Chen Noreen F. Rossi 《Journal of critical care》2014
Introduction
Arginine vasopressin’s (AVP) efficacy in the treatment of refractory hypotension is, in part, dependent upon preinfusion endogenous AVP concentration. Corticosteroids, also commonly used to treat refractory hypotension, have been shown to suppress endogenous AVP release. We aimed to determine if corticosteroids affect endogenous AVP concentrations in children recovering from cardiac surgery.Materials and methods
We reviewed the records of children who underwent cardiac surgery between January 2008 and January 2009 and had AVP concentrations available as part of a prior prospective study. Doses of hydrocortisone, methylprednisolone, and dexamethasone administered within the first 48 hours after cardiopulmonary bypass were quantitated. Multivariable linear regression was performed to determine if corticosteroids had a significant effect on 48-hour plasma AVP concentration.Results
Sixty-nine children with plasma AVP concentrations available were reviewed, 34 (49%) of which received corticosteroids within 48 hours after cardiopulmonary bypass. On multivariable regression, greater number of corticosteroid doses but not cumulative corticosteroid dosage was significantly associated with low 48-hour AVP concentration (β = − 4.0; 95% confidence intervals, − 6.5 to − 1.4).Conclusions
Children who receive multiple doses of corticosteroids after cardiac surgery, regardless of potency, are likely to have low endogenous AVP concentrations. Children who remain unstable despite corticosteroids may respond favorably to exogenous AVP therapy. 相似文献949.
Toshiki Kobayashi Michael S. Orendurff Ming Zhang David A. Boone 《Clinical biomechanics (Bristol, Avon)》2014