Cholesterin und Wasserhaushalt

Ohne ZusammenfassungErscheint ausführlich in der Zeitschr f. d. ges. exp. Med.     

Validation of a postoperative prognostic model consisting of tumor microvascular invasion, size, and grade to predict disease-free and cancer-specific survival of patients with surgically resected renal cell carcinoma

Objectives:   To determine the value of microvascular invasion, tumor size, and Fuhrman grade to predict the survival of patients with surgically resected renal cell carcinoma (RCC).
Methods:   A total of 771 consecutive patients (T1–4, Nx, M0) were retrospectively reviewed. For each patient with RCC, the prognostic Sao Paulo score (SPS) was calculated using the following variables: tumor size (>7 cm vs ≤7 cm), nuclear grading, and microvascular invasion. On the basis of SPS, patients were subdivided into low-risk (LR), intermediate-risk (IR), and high-risk (HR) groups. Disease-free survival (DFS) and cancer-specific survival (CSS) were estimated using the Kaplan–Meier method. Median follow-up was 80 months.
Results:   Median follow-up was 80 months. DFS rates after 5 years were 91.2%, 61.3%, and 51.9% in the original SPS LR, IR, and HR groups, respectively. CSS rates after 5 years were 94.3%, 79.8%, and 58.7%, respectively ( P  < 0.001). Each original SPS constituent revealed a significant influence on DFS and CSS in the multivariate analysis. By modification of the cut-off value of the maximum tumor size from 7 to 5 cm the predictive value of the SPS sum score was marginally enhanced. Using a cut-off value of 5 cm also resulted in a relatively better discrimination between the IR and the HR group regarding DFS and CSS.
Conclusions:   Stratifying RCC patients by SPS into LR, IR, and HR groups provides a clinically useful tool for outcome analysis and risk assessment. However, the prognostic value of the SPS could be enhanced by including a maximum tumor size with a cut-off at 5 cm into the sum score.     

Nutritional iron status of infants fed according to current recommendations

We examined the iron nutritional status of healthy term infants in a longitudinal study from 15 through 365 days of age. All infants were fed according to the present austrian recommendations. Serum hemoglobin (Hb) decreased from 15 through 122 days of age and remained constant thereafter. At 365 days of age, only 4.7% of the infants had hemoglobin levels below 11 g/dl, which is considered the borderline value for anemia. Mean corpuscular volume (MCV) of erythrocytes was changing during infancy. Free erythrocyte protoporphyrin (FEP) was constant from 122 days through 365 days of age. The upper normal value of 3 micrograms/gHb for infants older than 122 days of age corresponded to that for children older than one year and adults. Serum ferritin (SF) decreased from 15 through 183 days of age and remained constant thereafter. At 365 days of age, only 9.3% of the infants had SF below 10 micrograms/l, which is considered the borderline concentration for depletion of iron stores. We found no differences of iron nutritional status between infants who were breastfed longer than 122 days and infants who were breastfed shorter than 122 days or were fed formula. Our findings indicate that the prevalence of iron deficiency anemia and depletion of the iron stores is lower than in previous studies. Changes in infant nutrition during the last years resulted in higher iron intake and lower prevalence of iron deficiency.     

Zeitschriftenübersicht

Ohne Zusammenfassung     

Kurze Mitteilung über drei Fälle von Lymphangitis nach diagnostischen Tuberkulininjektionen

Ohne Zusammenfassung     

Die Syphillisätiologie der Frauentabes

Ohne Zusammenfassung     

ChondroitinschwefelsÄure im Serum

Zusammenfassung Im Serum von Amyloidkranken, aber auch im Serum von Lipoidnephrotikern usw. wird eine Vermehrung der ChondroitinschwefelsÄure nachgewiesen. Dies sowohl wie die Vermehrung der SchwefelsÄure in den nicht amyloidentarteten Geweben lÄ\t daran denken, da\ der Befund von ChondroitinschwefelsÄure im Amyloid auf eine Retention dieser normalerweise im Urin ausgeschiedenen Substanz zurückzuführen ist.