基于网络药理学和多中心临床数据的清肺承气汤治疗腹腔感染所致急性呼吸窘迫综合征的作用机制研究

目的 采用网络药理学和多中心临床数据探讨清肺承气汤治疗腹腔感染所致急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)的作用机制.方法 通过中药系统药理学分析平台(Traditional Chinese Medicine Systems Pharmacology Dat...     

去离子水污染导致生化分析仪单一佥测项目失控故障一例

本文对去离子水被污染而导致的甘油三酯单一检测项目失控的原因进行了分析。     

关节镜下关节腔清理术治疗痛风性膝关节炎的临床分析

目的 探讨关节镜下关节腔清理术治疗痛风性膝关节炎中的临床治疗效果。方法 选取2019年5月—2020年5月在医院收治的痛风性膝关节炎患者80例作为研究对象,按照治疗方式不同分为两组,各40例,其中,对照组患者接受保守治疗措施,观察组患者接受关节镜下关节腔清理术治疗措施,对两组患者的治疗情况进行观察并对比。结果 （1）观察组优16例,良20例,治疗优良率90.0%,对照组优6例,良22例,治疗优良率70.0%,差异有统计学意义（P <0.05）。（2）治疗后观察组膝关节疼痛情况（1.0±0.3）分、关节活动度（104.3±1.0）分、膝关节功能（48.4±1.2）分均显著优于对照组,差异有统计学意义（P <0.05）;(3)治疗后,观察组生理功能（91.4±3.1）分、社会功能（91.3±4.3）分、躯体疼痛（92.0±3.2）分、精神健康（91.2±2.5）分均显著高于对照组水平,差异有统计学意义（P <0.05）。结论 关节镜下关节腔清理术治疗痛风性膝关节炎中的临床效果显著,能够快速改善患者的膝关节疼痛情况,并且提高患者的生活质量,值得肯定,能够在临床上推广应用。     

Transport Property and Spin–Orbit Torque in 2D Rashba Ferromagnetic Electron Gas

In this paper, we investigate the spin–orbit torque and transport property in a 2D Rashba ferromagnetic electron gas. The longitudinal conductivity can be divided into two parts: the first term is determined by the charge density and is independent of the spin degrees of freedom. The second term depends on the two bands that spin in the opposite directions, and it is directly proportional to spin–orbit torque regardless of the band structure and temperature. This is a general and underlying relation between the transport property and spin–orbit torque. Moreover, we show the impacts of the spin–orbit coupling constant and Fermi energy on transverse conductivity and spin–orbit torque, which is helpful for relevant experiments.     

Does chronic kidney disease affect the complications and prognosis of patients after primary colorectal cancer surgery?

BACKGROUNDThe effect of chronic kidney disease (CKD) on the outcomes of colorectal cancer (CRC) patients after primary CRC surgery is controversial.AIMTo analyze whether CKD had specific effect on the outcomes after CRC surgery.METHODSWe searched the PubMed, Embase, Cochrane Library databases and CNKI, from inception to March 14, 2022. Newcastle-Ottawa Scale was used for the quality assessment in this meta-analysis, and we used RevMan 5.3 was used for data analysis.RESULTSA total of nine studies including 47771 patients were eligible for this meta-analysis. No significant difference was found in terms of overall postoperative complications [odds ratio (OR) = 1.78, 95%CI: 0.64-4.94, P = 0.27]. We analyzed the specific complications and found that the CKD group had higher rates of pulmonary infection (OR = 2.70, 95%CI: 1.82-4.00, P < 0.01), cardiovascular complications (OR = 3.39, 95%CI: 2.34-4.91, P < 0.01) and short-term death (OR = 3.01, 95%CI: 2.20-4.11, P < 0.01). After pooling the hazard ratio (HR), the CKD group had worse overall survival (OS) (HR = 1.51, 95%CI: 1.04-2.20, P = 0.03). We performed subgroup analyses of the dialysis and non-dialysis groups, and no significant difference was found in the non-dialysis group (HR = 1.20, 95%CI: 0.98-1.47, P = 0.08). The dialysis group had worse OS (HR = 3.36, 95%CI: 1.92-5.50, P < 0.01) than the non-dialysis group. The CKD group had worse disease-free survival (DFS) (HR = 1.41, 95%CI: 1.12-1.78, P < 0.01), and in the subgroup analysis of the dialysis and non-dialysis groups, no significant difference was found in the non-dialysis group (HR = 1.27, 95%CI: 0.97-1.66, P = 0.08). The dialysis group had worse OS (HR = 1.95, 95%CI: 1.23-3.10, P < 0.01) than the non-dialysis group.CONCLUSIONPreexisting CKD was associated with higher rates of pulmonary infection, higher rates of short-term death, and worse OS and poorer DFS following CRC surgery.     

Enhanced tumor homing of pathogen-mimicking liposomes driven by R848 stimulation: A new platform for synergistic oncology therapy

Although multifarious tumor-targeting modifications of nanoparticulate systems have been attempted in joint efforts by our predecessors, it remains challenging for nanomedicine to traverse physiological barriers involving blood vessels, tissues, and cell barriers to thereafter demonstrate excellent antitumor effects. To further overcome these inherent obstacles, we designed and prepared mycoplasma membrane (MM)-fused liposomes (LPs) with the goal of employing circulating neutrophils with the advantage of inflammatory cytokine-guided autonomous tumor localization to transport nanoparticles. We also utilized in vivo neutrophil activation induced by the liposomal form of the immune activator resiquimod (LPs-R848). Fused LPs preparations retained mycoplasma pathogen characteristics and achieved rapid recognition and endocytosis by activated neutrophils stimulated by LPs-R848. The enhanced neutrophil infiltration in homing of the inflammatory tumor microenvironment allowed more nanoparticles to be delivered into solid tumors. Facilitated by the formation of neutrophil extracellular traps (NETs), podophyllotoxin (POD)-loaded MM-fused LPs (MM-LPs-POD) were concomitantly released from neutrophils and subsequently engulfed by tumor cells during inflammation. MM-LPs-POD displayed superior suppression efficacy of tumor growth and lung metastasis in a 4T1 breast tumor model. Overall, such a strategy of pathogen-mimicking nanoparticles hijacking neutrophils in situ combined with enhanced neutrophil infiltration indeed elevates the potential of chemotherapeutics for tumor targeting therapy.     

淄博市生活饮用水中硝酸盐暴露及其健康风险的时空分布特征

目的 对饮用水硝酸盐进行健康风险评估,为水质干预决策提供技术依据。 方法 对2016~2020年淄博市2 575份城乡饮用水样品检测硝酸盐含量,采用我国《化学物质环境健康风险评估技术指南》(WS/T 777-2021)的环境健康风险评价模型,分析不同年度、不同监测点类型、不同水源、不同处理方式的硝酸盐含量和非致癌健康风险的时空分布特征。 结果 2016~2020年共检测水样2 575份,硝酸盐超标率为10.76%。饮用水硝酸盐含量具有空间聚集性,高值主要集中在沂源县中部和东部、博山区西南部,低值集中在高青县和桓台县。饮用水硝酸盐含量和非致癌健康风险总体呈现逐年升高趋势,农村水高于城区水、地下水高于地表水、未处理水高于处理水。5年总体平均非致癌风险为0.21,对人体产生的非致癌风险较低;最高非致癌风险为1.99,主要集中在沂源县,对人体存在长期暴露的非致癌健康风险。 结论 淄博市局部区域饮用水硝酸盐污染较严重,存在非致癌健康风险,应引起关注并采取水质干预措施。     

白塞综合征20例临床特征及心血管影像学分析

回顾性分析2018年1月—2020年8月首都医科大学附属北京安贞医院风湿免疫科治疗的白塞综合征患者20例的临床及影像学检查资料.20例患者中,男4例,女16例,平均年龄41.2岁,平均病程17.0年.超声、CT及MR检查发现心血管系统受累13例,主要表现为主动脉瓣脱垂并重度关闭不全,主动脉瘤、主动脉假性动脉瘤、主动脉溃...