Treatment strategies for Henoch-Schönlein purpura nephritis by histological and clinical severity

The management of Henoch-Sch?nlein purpura nephritis (HSPN) is controversial. It has been revealed that some patients develop end-stage renal disease and aggressive treatment with drugs such as steroids is increasing, and some of them may be overzealous. At our institutes, our treatment decisions are based on the clinical and pathological severity of the case in an attempt to limit the indications for aggressive therapies such as steroids and immunosuppressive agents. Here, we retrospectively examined the efficacy of treatment for HSPN. Renal biopsy was performed in patients with nephrotic syndrome or persistent proteinuria for more than 3 months and patients were classified by treatment. Patients (n=31) with moderately severe HSPN (histological grade I-III and serum albumin [Alb] >2.5 g/dl) were treated with angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers. Patients (n=19) with HSPN exceeding grade III or Alb ≤ 2.5 g/dl received combination therapy comprising prednisolone, immunosuppressants, warfarin, and dipyridamole. All patients showed resolution of proteinuria without renal dysfunction during the observation period (3.76 ± 0.37 years). Our findings support those of some earlier reports that treatment strategies for HSPN should depend on the histological and clinical severity. Furthermore, aggressive therapies, particularly combination therapies, are unnecessary for moderate-severe HSPN.     

Comparison of fat suppression techniques of bilateral breast dynamic sequence at 3.0 T: utility of three-point DIXON technique

The purposes of this study were to determine optimum flip angles (FAs) and to compare the effectiveness of fat suppression and signal homogeneity among three techniques, spectral attenuated with inversion recovery (SPAIR), principle of selective excitation technique (PROSET), and three-point DIXON technique (DIXON), of the bilateral breast dynamic sequence acquired using the optimum FA at 3.0 T. Using a homemade phantom that represented a tumor, fat, and a mammary gland, the optimum FAs were determined from the change of fat signal intensity, signal-to-noise ratio (SNR) of the mammary gland, and contrast ratio (CR) between the tumor and mammary gland. The effectiveness of fat suppression and signal homogeneity were compared in ten breast cancer cases, using the CR between fat and pectoralis muscle signal intensities and the standard deviation (SD) of fat signal intensity, respectively. The optimum FAs for SPAIR, PROSET, and DIXON were 10, 20, and 20 degrees, respectively. The mean CR between fat and pectoralis muscle signal intensities achieved using SPAIR, PROSET, and DIXON were 0.19, 0.30 and 0.40, respectively, and the mean SDs of the fat signal intensities were 90.2, 103.1, and 30.5, respectively. The DIXON technique provided better fat suppression and signal homogeneity than the other two techniques. The results of this study suggest the possible application of the DIXON technique in combination with the optimum FA setting as an effective fat suppression technique for the bilateral breast dynamic sequence at 3.0 T.