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51.
本文报道我国西南产麻黄——丽江麻黄Ephedra likiangensis Florin、匍枝丽江麻黄E.likiangensis f.mairei(Florin)C.Y.Cheng、藏麻黄E.saxatilis Royle ex Florin、山岭麻黄E.gerardiana Wall、垫状山岭麻黄E.gerardiana Var.congesta C.Y.Cheng、矮麻黄E.minuta Florin和异株矮麻黄E.minuta var.dioeca C.Y.Cheng,以及形态组织特征较特殊的宁夏产斑子麻黄E.lepidosperma C.Y.Cheng、新疆产窄膜麻黄E.lomatolepis Schrenk,西藏产西藏中麻黄E.intermedia var.tibetica Stapf的生药形态组织学研究结果。并根据对国产麻黄的生药形态组织学的系统研究结果,分别编写了各种国产麻黄(包括13种3变种1变型)的生药性状和生药显微特征检索表。 相似文献
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High mobility group box 1 (HMGB1) mediates proinflammatory responses in inflammatory diseases. Lycopene found in tomatoes and tomato products has anti-oxidant, anti-cancer and antiinflammatory effects. The potential anti-inflammatory roles of lycopene in HMGB1-mediated proinflammatory responses in both primary human umbilical vein endothelial cells (HUVECs) and animal were investigated. The anti-inflammatory effects of lycopene were determined including permeability, monocyte adhesion and migration, and activation of proinflammatory proteins and HMGB1 receptors on HMGB1 activated HUVECs. In the in vivo model, the anti-inflammatory effect of lycopene was assessed by monitoring vascular permeability and migration of leukocytes to the peritoneal cavity of mice injected with lycopene. Lycopene inhibited lipopolysaccharide (LPS)-mediated release of HMGB1, expression of HMGB1-mediated tumor necrosis factor (TNF)-secretory phospholipase A2 (sPLA2)-IIA, and HMGB1-mediated pro-inflammatory signaling responses in endothelial cells. It did this through down-regulation of cell surface expression of cell adhesion molecules (CAMs), HMGB1 receptors, toll-like receptor (TLR)-2, and -4, and receptors for advanced glycation end products (RAGE). These findings suggest that lycopene promotes barrier integrity, inhibits monocyte adhesion and migration to HMGB1 activating HUVECs by blocking activation of proinflammatory cytokines and expression of CAMs and HMGB1 receptors, thereby showing its usefulness as a therapy for vascular inflammatory diseases. 相似文献
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Kuś E Kazimierak W Swierczewski A Kowalska-Koprek U Karowicz-Bilińska A 《Ginekologia polska》2008,79(3):212-217
Le?niowski-Crohn disease is an inflammatory process, involving all layers of the intestine, mesentery and regional lymph nodes. During the development of the disease, a thickening of the intestine wall, stricture of its lumen and adhesions have been observed. The aim of the study was to present the case of a 27-year-old pregnant woman with Crohn's disease, a very rare complication of gestation. 相似文献
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Saglam A Bozdag G Kuzey GM Kuçukali T Ayhan A 《Archives of gynecology and obstetrics》2008,277(6):557-562
Objective To present a unique case of a 63 year-old woman with coexistent adenocarcinoma of the ovary, endometrium, cervix and fallopian
tube.
Materials and methods A case report from a tertiary health center.
Results A woman presenting with postmenopausal bleeding and abdominal distantion was assessed by endometrial biopsy and explorative
surgery. The frozen section of the mass on the right adnex revealed malign mucinous carcinoma of the ovary. As usual, optimal
debulking was performed as initial surgical staging procedure of ovarian cancer. The microscopic examination of the right
ovary revealed a typical mucinous cystadenocarcinoma. Furthermore, the focal endometrial irregularity at the left uterine
cornus turned out to be a well differentiated endometrial carcinoma of the endometrioid type with <1/3 myometrial invasion.
The pale infiltrative lesion in the cervix also turned out to be an adenocarcinoma of the endocervical type with deep stromal
invasion and areas of diffuse glandular dysplasia and in-situ glandular neoplasia at the periphery. Besides, several sections
from the left fallopian tube uncovered diffuse dysplasia in the lining epithelium and a focus of adenocarcinoma with papillary
and cribriform pattern.
Discussion When compared with patients having metastatic lesions, most synchronous female malignancies are accompanied with early stage
and low-grade with a more favorable prognosis. However, there is paucity of data for the exact criterion to distinguish primary
tumors from metastatic lesions. In such cases, the validity of immunohistochemical and cloning studies are not clear. 相似文献
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BACKGROUND: Total thyroidectomy is increasingly being adopted for patients requiring surgical treatment for Graves' disease based on a comparable surgical risk and the lack of recurrence, as well as the questionable ability of subtotal thyroidectomy to maintain euthyroidism. The purpose of the present paper was to evaluate its safety and efficiency. METHODS: Total thyroidectomy was adopted as part of the routine surgical treatment for Graves' disease from 2000. Patients who underwent subtotal thyroidectomy (STT) from 1995 to 1999 (n = 119) were compared with those who underwent total thyroidectomy (TT) from 2000 to 2003 (n = 98) with respect to immediate postoperative morbidity and long-term outcome. RESULTS: Fourteen (11.8%) and 22 patients (22.4%) required calcium supplement on discharge in the STT and TT groups, respectively (P < 0.05). One (0.8%) and three patients (3.1%) developed permanent hypocalcaemia, respectively. Transient recurrent laryngeal nerve palsy occurred in 9.2% (n = 11) and 5.1% (n = 5) of patients or 5.0% and 2.6% of nerves at risk after STT and TT, respectively. None of the patients had permanent nerve palsy. The estimated blood loss was less and hospital stay shorter after TT. During a mean follow up of 64 months, 86 patients (72.3%) in the STT group required thyroxine replacement and seven patients (5.9%) developed relapse. CONCLUSION: Subtotal thyroidectomy was associated with relapse as well as hypothyroidism in a significant proportion of patients during long-term follow up. Total thyroidectomy can be performed as safely as STT and should be recommended as the procedure of choice for patients requiring surgical treatment for Graves' disease. 相似文献
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Fermentation of medicinal herbs improves their pharmacological efficacy. In this study, we investigated the effects of red-koji fermented red ginseng (fRG) on high-fat diet (HFD)-mediated metabolic disorders, and those effects were compared to those of non-fermented red ginseng (RG). fRG (500, 250 or 125 mg/kg), RG (250 mg/kg), simvastatin (10 mg/kg), silymarin (100 mg/kg) and metformin (250 mg/kg) were orally administered from 1 week after initiation of HFD supply for 84 days. The diameter of adipocytes in periovarian and abdominal fat pads and the thickness of the abdominal fat were significantly decreased by fRG treatment, while HFD-mediated weight gain was partly alleviated by fRG in a dose-dependent manner. Moreover, biochemical and histomorphometrical analyses clearly indicated that fRG significantly inhibited HFD-induced metabolic disorders such as hyperglycemia, hyperlipidemia, hepatopathy and nephropathy in a dose-dependent manner. More favorable pharmacological effects on HFD-mediated metabolic disorders were also observed with fRG compared to an equal dose of RG. This finding provides direct evidence that the pharmacological activities of RG were enhanced by red-koji fermentation, and fRG could be a neutraceutical resource for the alleviation of obesity-mediated metabolic disorders. 相似文献
60.
目的 建立利用半导体探测器阵列检测多叶准直器(MLC)叶片定位误差的方法,用于MLC的日常质量保证。方法 在MapCheck半导体探测器阵列上,相邻行探测器是错开半个探测器间距分布的。针对这种分布特点,设计了台阶式叶片位置模式,代替胶片测量常用的篱笆式(picket fence)叶片位置模式,作为叶片位置参考模式。在参考模式的基础上,人为引入不同大小的叶片位置误差,得到一组新的叶片位置模式——叶片位置校准模式。依次照射参考模式和校准模式,得到每一个探测器测量剂量与叶片位置误差的关系曲线。该曲线作为测量叶片位置误差的校准曲线。在进行MLC日常质量保证时,只需定期照射叶片位置参考模式,就可得到定量的叶片位置误差。结果 新方法在一个配置40对MLC的加速器上进行了测试(Elekta Precise)。篱笆式叶片位置模式一次检测160个叶片位置,而台阶式叶片位置模式一次检测240个位置, 检测效率提高50%;对于同样的1mm叶片误差,前后两种模式的剂量变化分别是17%和25%,因此测量灵敏度提高8%。结论 建立了一种新的定量的MLC日常QA方法。通过重新设计叶片位置模式,新方法提高了实施效率和测量灵敏度。 相似文献