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71.
Krystian Obara Marta Waliszewska-Prosół Sławomir Budrewicz Paweł Szewczyk Maria Ejma 《Neurologia i neurochirurgia polska》2018,52(3):397-400
Neuromyelitis optica (NMO) is a rare, disabling, recurring inflammatory demyelinating disease affecting the spinal cord and optic nerves with predominance in women.We present the case of a female patient with chronic C hepatitis, who, despite treatment, developed severe symptoms of NMO during pregnancy and postpartum. 相似文献
72.
Konrad Kleszczyski Tae‐Kang Kim Bernadetta Bilska Michal Sarna Krystian Mokrzynski Agatha Stegemann Elbieta Pyza Russel J. Reiter Kerstin Steinbrink Markus Bhm Andrzej T. Slominski 《Journal of pineal research》2019,67(4)
Melanogenesis is a key parameter of differentiation in melanocytes and melanoma cells; therefore, search for factors regulating this pathway are strongly desired. Herein, we investigated the effects of melatonin, a ubiquitous physiological mediator that is found throughout animals and plants. In mammals, the pineal gland secretes this indoleamine into the blood circulation to exert an extensive repertoire of biological activities. Our in vitro assessment indicates an oncostatic capacity of melatonin in time‐dependent manner (24, 48, 72 hours) in highly pigmented MNT‐1 melanoma cells. The similar pattern of regulation regarding cell viability was observed in amelanotic Sk‐Mel‐28 cells. Subsequently, MNT‐1 cells were tested for the first time for evaluation of melanin/melatonin interaction. Thus primary, electron paramagnetic resonance (EPR) spectroscopy demonstrated that melatonin reduced melanin content. Artificially induced disturbances of melanogenesis by selected inhibitors (N‐phenylthiourea or kojic acid) were slightly antagonized by melatonin. Additionally, analysis using transmission electron microscopy has shown that melatonin, particularly at higher dose of 10?3 mol/L, triggered the appearance of premelanosomes (stage I‐II of melanosome) and MNT‐1 cells synthesize de novo endogenous melatonin shown by LC‐MS. In conclusion, these studies show a melanogenic‐like function of melatonin suggesting it as an advantageous agent for treatment of pigmentary disorders. 相似文献
73.
74.
Marek Hartleb Krystian Rudzki Ewa Karpel Alina Becker Marek Waluga Hubert Boldys Andrzej Nowak Stanislaw Nowak 《Liver international》1997,17(1):1-6
Abstract: It seems that hypervolemia and vasodilatation coincide in compensated cirrhosis, but neither rank nor importance of these factors has been fully clarified in adaptive response to postural change. We studied, with gated equilibrium radionuclide angiography and thoracic electrical bioimpedance the hemodynamic status of 19 patients with compensated cirrhosis and 18 healthy subjects in upright and supine positions. In the upright position, the cirrhotic patients were hypotensive and had decreased peripheral vascular resistance despite increased cardiac output. The transition to the supine position was accompanied by a significant fall in the heart rate and an increase in the stroke volume in both controls (92±22 to 63±10 beats/min, and 38±9 to 62±19 ml/m2, respectively) and cirrhotic patients (101±20 to 79±13 beats/min, and 44±15 to 63±19 ml/m2, respectively). Besides, the diastolic arterial pressure fell in controls from 89±9 mmHg to 81 ± 11 mmHg; p <0.01, while it remained unchanged in cirrhotic patients (77±17 vs 82±13 mmHg). In the supine position, the cirrhotic patients presented tachycardia and left ventricular hyperkinesy (increased velocity of left ventricular filling and emptying). In conclusion, these results show that in compensated cirrhosis the decreased arterial tone and peripheral blood pooling are important factors of adaptive hemodynamic reaction to postural change. 相似文献
75.
Beata Morak-Młodawska Krystian Pluta Małgorzata Latocha Małgorzata Jeleń 《Medicinal chemistry research》2016,25(11):2425-2433
New phenothiazine derivatives as 10-substituted dipyridothiazines of the 1,6-diazaphenothiazine structure were obtained in the cyclization reaction of 3-amino-3′-nitro-2,2′-dipyridinyl sulfide and 3,3′-dinitro-2,2′-dipyridinyl disulfide, and in the reaction of 2-chloro-3-ntropyridine with sodium 3-amino-2-pyridinethiolate followed by various alkylation and arylation reactions. The reaction of the thiazine ring formation ran via the Smiles rearrangement of the S-N type. As the alkylation reactions could proceed at the thiazine, azine or both nitrogen atoms, the product structure elucidation was based on the 2D NMR (Rotating-frame Overhauser Effect Spectroscopy, Correlated Spectroscopy, Heteronuclear Single Quantum Coherence, and Heteronuclear Multiple Bond Correlation) spectra of the N-methylated product. Some 10-substituted 1,6-diazaphenothizines (5, 10, 12, 13) were at least anticancer active against melanoma C-32 and breast cancer MCF-7 cell lines as a reference drug – cisplatin. The monoazaphenothiazine drug, prothipendyl, turned out to be less active than least 6 derivatives of the 1,6-diazaphenothiazine structure. 相似文献
76.
Swierczynski J Korczynska J Goyke E Adrych K Raczynska S Sledzinski Z 《Obesity surgery》2005,15(6):803-808
Background: Human obesity is associated with increased serum hepatocyte growth factor (HGF) concentration. This study examines
whether reduced body fat mass after vertical banded gastroplasty (VBG) is associated with a decrease in serum HGF concentration.
Methods: Serum HGF concentration and body weight, BMI, body fat mass, blood pressure, serum leptin, insulin, triacylglycerol,
and cholesterol concentrations were studied in 10 obese women before and 1 year after VBG. 10 lean, healthy women were used
as controls. Results: Obese women showed significantly higher serum HGF concentration than control (lean, healthy) subjects.
The mean serum HGF concentration decreased significantly 1 year after VBG, but did not reach the value observed in lean women.
After VBG, BMI, body fat mass and serum HGF had similar patterns of decrease. Moreover, serum HGF concentration was positively
correlated with both BMI (r=0.6, P<0.01) and body fat mass (r=0.6, P<0.01). Before surgery in obese women, elevated blood pressure was observed, which decreased after VBG. Linear regression
analysis between blood pressure and serum HGF concentration using all subjects, showed no correlation between either systolic
blood pressure and serum HGF concentration (r=.15, P=NS) or between diastolic blood pressure and serum HGF concentration (r=0.1, P=NS). Insulin resistance index (HOMA score), serum leptin, insulin and triacylglycerol concentrations decreased 1 year after
VBG. However, serum cholesterol concentration did not change significantly. Conclusions: These results indicate that VBG results
in a reduction in circulating HGF concentration. The reduced body fat mass may contribute in part to the decrease of serum
HGF concentration after VBG. Because elevated serum HGF concentration may contribute to the progression of atherosclerosis,
the decrease in serum HGF concentration after VBG may be beneficial for obese subjects. 相似文献
77.
Wojciech Wróbel Maciej Sosnowski Krystian Wita Maria Trusz-Gluza 《The international journal of cardiovascular imaging》2009,25(7):649-651
We present a case of a 69 year-old woman complaining of palpitations and worsening heart failure, after the 2nd cycle of fludarabine
due to Hodgkin’s lymphoma. Echocardiography revealed abnormalities typical for corrected transposition of the great arteries
(CTGA), which were confirmed in multislice computed tomography (MSCT), as well as subvalvular pulmonary stenosis. There is
the case of one of the oldest patients with CTGA and subvalvular pulmonary stenosis. MSCT seems to be a useful and complementary
method in diagnosis such diseases. 相似文献
78.
79.
This review summarizes recent medicinal chemistry investigations in vitro and in vivo in search for new phenothiazines of promising biological activities. New phenothiazine derivatives (over 50 main structures) contain dialkylaminoalkyl, cycloaminoalkyl and aminoalkyl substituents and their acyl and sulfonyl derivatives, and other substituents with varied the monocyclic (pyrazole, thiazole, oxadiazole, thiadiazole, tetrazole) and bicyclic (quinolizine, pyrazolopyrimidine, thiazolopyridine, azabicyclononane and spiro[chromanpyrimidine] heterocycles linked directly or via the alkyl chain with the thiazine nitrogen atom or with the benzene ring. The modifications of the tricyclic ring system with the bicyclic homoaromatic ring (naphthalene) and monocyclic and bicyclic azine rings (pyridine, pyrimidine, pyrazine and quinoline) led to compounds of significant biological activities. Recently obtained phenothiazines exhibit promising antibacterial, antifungal, anticancer, antiviral, anti-inflammatory, antimalarial, antifilarial, trypanocidal, anticonvulsant, analgesic, immunosuppressive and multidrug resistance reversal properties. These activities were the results of the actions of phenothiazines on biological systems via the interaction of the pharmacophoric substituent (in some cases of strict length), via the interaction of the multicyclic ring system (π-π interaction, intercalation in DNA) and via the lipophilic character allowing the penetration through the biological membranes. The activities were examined by using various biological systems such as cell lines, bacteria, viruses, parasites, laboratory mice, rats and rabbits, and monolayer and bilayer membranes. Some mechanisms of the actions are discussed. This review shows current tendency in the phenothiazine synthesis (without synthetic routes) and reveals the phenothiazine core to be very potent pharmacophoric moiety which can be a rich source of new compounds having desirable biological activities. 相似文献
80.
Obolewski K Skorbiłowicz E Skorbiłowicz M Glińska-Lewczuk K Astel AM Strzelczak A 《Ecotoxicology and environmental safety》2011,74(4):558-568
Studies on trace elements in reed stands and limiting effect of the reed substrate on the periphyton structure were performed in various aquatic ecosystems of Greece during the summer and autumn of 2006. The analysed factors were concentrations of chemical elements (cadmium, lead, zinc, chromium, nickel, copper, cobalt, iron, manganese, potassium, sodium, calcium, magnesium) in reed shoots as well as the density of zooperiphyton and phytoperiphyton taxa. The relationships between metal concentrations and periphyton structure were determined with the use of the multivariate methods Canonical Correspondence Analysis (CCA), Detrended Correspondence Analysis (DCA) and RDA (Redundancy Analysis). The results showed that bioaccumulation of lead and cadmium in the reed had the most negative influence on zooperiphyton species, while low concentrations of alkali metals favoured the occurrence of Cyclopoida, Cladocera (Chydorus sp.) and Oligochaeta (Neis sp.). A considerable resistance to toxic heavy metals characterised Cyanophyta representatives and, partly, colonial Bacillariophyta. High concentrations of alkali metals supported the presence of unicellular Bacillariophyta but diminished the densities of colonial Bacillariophyta and Chlorophyta of the genus Scenedesmus. 相似文献