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排序方式: 共有501条查询结果,搜索用时 15 毫秒
41.
Gan TJ Apfel CC Kovac A Philip BK Singla N Minkowitz H Habib AS Knighton J Carides AD Zhang H Horgan KJ Evans JK Lawson FC;Aprepitant-PONV Study Group 《Anesthesia and analgesia》2007,104(5):1082-9, tables of contents
42.
Djordjije Saranovic Jelena Djokic Kovac Srbislav Knezevic Snezana Susnjar Aleksandra Djuric Stefanovic Dragana Sobic Saranovic Vera Artiko Vladimir Obradovic Dragan Masulovic Marjan Micev Predrag Pesko 《JOURNAL OF BREAST CANCER》2011,14(3):247-250
Gastrointestinal metastases from invasive lobular breast cancer are uncommon with the stomach and small intestines being the most common metastatic sites. Peritoneal and rectal metastases are very rare and only rarely occur as the first manifestation of disease. We herein report the case of a 47-year-old woman who presented with abdominal carcinomatosis as a first sign of invasive lobular breast carcinoma (ILC). Identifying the most important immunohistochemical markers for ILC: gross cystic disease fluid protein 15, estrogen and progesterone receptors enabled a correct diagnosis. After a six year disease-free period, relapse occurred with severe obstruction due to rectal metastasis from lobular breast carcinoma. Since there was no widespread metastatic disease, surgery with concomitant hormonal therapy was performed. 相似文献
43.
Koson P Zilka N Kovac A Kovacech B Korenova M Filipcik P Novak M 《The European journal of neuroscience》2008,28(2):239-246
We have previously demonstrated in a transgenic rat model of tauopathy that human misfolded truncated tau derived from Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo . We employed this model to investigate the impact of truncated tau expression levels on life span, neuronal loss and the final load of neurofibrillary tangles (NFTs) in transgenic rats. Two independent transgenic lines (SHR72, SHR318), that display different expression levels of truncated tau, were utilized in this study. We found that transgene expression levels in the brain of SHR72 rats were 44% higher than in SHR318 rats and that truncated tau protein levels determined the survival rate of transgenic rats. The line with higher expression levels of truncated tau (SHR72) showed decreased median survival (222.5 days) when compared with the line with lower expression (SHR318; 294.5 days). Interestingly, NFT loads (total NFT/total neurons) were very similar in terminal stages of disease in both transgenic lines (SHR72 – 10.9%; SHR318 – 11.6%), despite significantly different expression levels of truncated tau. Moreover, mean neuron numbers in the hippocampus (CA1–3) and brain stem (gigantocellular reticular nucleus) in the two transgenic rat strains in the terminal stages of disease were similar, and did not differ significantly from those observed in age-matched non-transgenic controls. These findings suggest that the expression levels of misfolded truncated tau determine the life span in a transgenic rat model of tauopathy without causing neuronal loss or correlating with terminal NFT load. 相似文献
44.
A L Kovac P S Bennets S Ohara B A LaGreca J A Khan J W Calkins 《Journal of clinical anesthesia》1992,4(4):315-320
STUDY OBJECTIVE: To determine the effectiveness of esmolol hydrochloride (Brevibloc) as an additional adjunct to low-dose alfentanil premedication in controlling the hemodynamic response [heart rate (HR), mean arterial pressure (MAP), and intraocular pressure (IOP)] to succinylcholine and endotracheal intubation. DESIGN: Randomized, double-blind, placebo-controlled, prospective study. SETTING: Ambulatory gynecologic surgery at a university medical center. PATIENTS: Twenty ASA physical status I and II female patients scheduled for outpatient laparoscopy under general anesthesia. INTERVENTIONS: All patients received alfentanil 10 micrograms/kg as a preoperative medication 4 minutes prior to induction of anesthesia. Study patients (n = 10 in each group) received either esmolol 1.5 mg/kg or a placebo (normal saline) 30 seconds prior to induction (210 seconds after alfentanil and 90 seconds prior to endotracheal intubation). Anesthesia was induced with thiopental sodium 5 mg/kg and succinylcholine 1 mg/kg. Postintubation, 70% nitrous oxide, 30% oxygen, and 1% isoflurane were administered. MEASUREMENTS AND MAIN RESULTS: Time of study drug administration was defined as time zero. Measurements of HR, MAP, and IOP were made at baseline (patient awake) and at each minute from minutes 1 through 6 after administration of the study drug (time zero). Analysis of variance was used to analyze the data, with a value of p less than 0.05 considered significant. Esmolol 1.5 mg/kg was found to blunt the maximum increase in HR but not MAP or IOP following low-dose alfentanil premedication. CONCLUSIONS: In an eye patient with coronary artery disease, or in any patient in whom tachycardia may be detrimental, esmolol may be a useful adjunct in combination with low-dose alfentanil to attenuate the increase in HR due to laryngoscopy and endotracheal intubation. 相似文献
45.
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47.
Evolution of renal replacement therapy in Central and Eastern Europe 7 years after political and economical liberation 总被引:4,自引:4,他引:0
Rutkowski B; Ciocalteu A; Djukanovic L; Kiss I; Kovac A; Krivoshiev S; Kveder R; Polenakovic M; Puretic Z; Stanaityte M; Tareyeva I; Teplan V; Central; Europe Advisory Board in Chronic Renal Failure E; Zaitz J 《Nephrology, dialysis, transplantation》1998,13(4):860-864
Purpose of the study: The conditions of renal
replacement therapy (RRT) were very poor in the countries located in
Central and Eastern Europe (CEE) when they were members of the so-called
'socialist bloc'. The aim of the present analysis was to document the
impact of the socioeconomic changes on dialysis therapy in the CEE
countries. Design: This was a special survey with the
participation of 12 CEE countries, with data obtained through national
registries (with the exception of Russia). Results:
during the period 1990-1996 the number of haemodialysis units increased by
56% and the number of centres performing peritoneal dialysis by 296%. The
number of patients increased respectively by 78% (haemodialysis) and 306%
(peritoneal dialysis). The percentage of patients with diabetic nephropathy
and elderly patients rose dramatically during this period. One of the main
reasons of such expansion was the rapid development of peritoneal dialysis
programmes in the majority of the CEE countries. The introduction of modern
haemodialysis machines and a wider choice of different dialysers and
concentrates permitted individualization of dialysis procedures. These
points and the wider use of erythropoietin had a positive influence on
quality of life and treatment outcome. There was also a notable increase in
the number of transplant centres, but less so of the number of transplanted
patients. Conclusion: Renal replacement therapy
experienced a major expansion in the CEE countries. Despite progress
achieved, the level of RRT is not yet completely satisfactory in most CEE
countries. 相似文献
48.
49.
UDS and SCE in lymphocytes of persons occupationally exposed to low levels of ionizing radiation 总被引:2,自引:0,他引:2
Unscheduled DNA synthesis induced by in vitro UV irradiation was investigated in lymphocytes of persons occupationally exposed to low doses of ionizing radiation (maximum registered radiation dose: 98 mrad/month). For radiation exposures greater than 14 mrad/month above background level, increased rates of UDS after in vitro UV irradiation of lymphocytes were found. The bromodeoxyuridine differential chromatid labeling technique was applied to the examination of spontaneous and Mitomycin C (MMC)-induced sister chromatid exchanges (SCE) in the same population. No statistically significant difference could be determined in spontaneously occurring SCEs, while MMC induced SCEs were significantly reduced in persons exposed to radiation doses greater than 14 mrad/month, thus indicating increased repair capability for DNA lesions inflicted by a second insult after protracted low-dose irradiation. 相似文献
50.