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101.
102.
103.
Teke Z Aytekin FO Kabay B Yenisey C Aydin C Tekin K Sacar M Ozden A 《World journal of surgery》2007,31(9):1835-1842
Background Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight thiol antioxidant and potent inhibitor of nuclear factor-κB (NF-κB)
activation. It has been shown to attenuate local harmful effects of ischemia/reperfusion (I/R) injury in many organs. In recent
animal studies, a delaying effect of remote organ I/R injury on the healing of colonic anastomoses has been demonstrated.
In this study we investigated whether PDTC prevents harmful systemic effects of superior mesenteric I/R on left colonic anastomosis
in rats.
Methods Anastomosis of the left colon was performed in 40 rats randomly allocated into the following four groups: (1) Sham-operated
group (group I, n = 10)—simultaneously with colonic anastomosis, the superior mesenteric artery and collateral branches divided from the celiac
axis and the inferior mesenteric artery were isolated but not occluded. (2) Sham+PDTC group (group II, n = 10)—identical to sham-operated rats except for the administration of PDTC (100 mg/kg IV bolus) 30 minutes prior to commencing
the experimental period. (3) I/R group (group III, n = 10)—60 minutes of intestinal I/R by superior mesenteric artery occlusion. (4) PDTC-treated group (group IV, n = 10)—PDTC 100 mg/kg before and after the I/R. On postoperative day 6, all animals were sacrificed, and anastomotic bursting
pressures were measured in vivo. Tissue samples were obtained for investigation of anastomotic hydroxyproline (HP) contents,
perianastomotic malondialdehyde (MDA) levels, myeloperoxidase activity (MPO), and glutathione (GSH) level.
Results There was a statistically significant decrease in anastomotic bursting pressure values, tissue HP content and GSH level, along
with an increase in MDA level and MPO activity in group III, when compared to groups I, II, and IV (p < 0.05). However, PDTC treatment led to a statistically significant increase in anastomotic bursting pressure values, tissue
HP content and GSH level, along with a decrease in MDA level and MPO activity in group IV (p < 0.05).
Conclusions This study showed that PDTC treatment significantly prevented the delaying effect of remote organ I/R injury on anastomotic
healing in the colon. Further clinical studies are needed to clarify whether PDTC may be a useful therapeutic agent for increasing
the safety of the anastomosis during particular operations where remote organ I/R injury occurs. 相似文献
104.
The concomitant presence of myeloproliferative disorders and the need for coronary artery bypass surgery is a surgical dilemma. Thrombosis and hemorrhage can cause difficult problems and might require different approaches during and after surgery. We report a patient who had idiopathic myelofibrosis and underwent a successful coronary artery bypass surgery. 相似文献
105.
Nazlı Altin DDS PhD Sertan Ergun Joseph Katz Erkan Sancakli DDS PhD Meltem Koray DDS PhD Hakkı Tanyeri DDS PhD 《Journal of prosthodontics》2013,22(7):581-586
Pemphigus vulgaris (PV) is a rare mucocutaneous vesiculobullous disease characterized by the development of autoantibodies against the desmosomal proteins. Current treatment is largely based on systemic immunosuppression using systemic corticosteroids. Immunosuppressive drugs used in the treatment of the disease may increase the risk of infection and delayed healing, which are of concern in dental treatment procedures in this group of patients. The clinical outcomes of implants in PV have not been investigated. We present a case of PV rehabilitated with an implant‐supported prosthesis with a 32‐month follow‐up and discuss the important points in the surgical and prosthodontic phases. 相似文献
106.
107.
Ender Odemis Figen Gurakan Koray Ergunay Aysel Yuce Hasan Ozen Nurten Kocak 《Indian journal of gastroenterology》2004,23(4):135-137
BACKGROUND: TTV DNA has been reported in patients with a broad spectrum of hepatic disorders as well as in healthy people. AIM: To clarify the role of TTV in children with liver disease and in healthy children. METHODS: Degenerate primers designed to amplify a target sequence from the ORF 1 region of TTV genome were used for nested PCR, to detect TTV DNA in sera. RESULTS: TTV was detected in 3 of 18 children with chronic hepatitis B (16.7%), 2 of 17 hepatitis B carriers (11.8%), 2 of 17 children with cryptogenic chronic liver disease (11.8%), and 1 of 40 (2.5%) children without liver disease. The infection rate was similar among the various study groups and in the various age groups. There was no difference between TTV positive and negative children in respect to gender, history of surgery, parenteral treatment, transfusion of blood and blood products, presence of hepatomegaly, splenomegaly, jaundice, and transaminase values. CONCLUSION: TTV does not seem to have an etiologic role in cryptogenic liver disease in children and does not seem to influence the clinical course of liver disease. 相似文献
108.
Osman Ersoy Rasit Aran Musa Aydinli Ozlem Yonem Ozgur Harmanci Bulent Akdogan Ahmet Pinar Cenk Sokmensuer Yusuf Bayraktar 《Indian journal of gastroenterology》2006,25(5):258-259
Intravesical bacillus Calmette-Guerin (BCG) is used in patients with urinary bladder carcinoma. Although it is generally well tolerated, granulomatous hepatitis is a rare but serious complication. We report a 42-year-old man and a 56-year-old man who developed granulomatous hepatitis following intravesical BCG. One of them was treated successfully with antitubercular therapy; the other died because of BCG sepsis and multi-organ failure. 相似文献
109.
It is known that the overproduction of nitric oxide (NO) by nitric oxide synthase (NOS) occurs during the progression of various
inflammatory diseases in intestinal tract. NOS inhibitors or inducible nitric oxide synthase (iNOS) gene expression inhibitors
should be considered as potential anti-inflammatory agents, as NO synthesized by iNOS is related to various pathophysiological
processes including inflammation. In order to understand the relationship between iNOS and pathological reactions such as
the inflammatory process and malign transformation clearly, the existence and amount of constitutive expression should be
determined. It is crucial to comprehend the harmful and protective amounts of iNOS expressions in order to clarify the relationship
between iNOS and pathological processes. Evidently, only after this inspection is it possible to utilize iNOS as a marker
and treatment instrument during the diagnosis and treatment of malign transformation and the inflammatory process. 相似文献
110.