Epigenetic change in e-cardherin and COX-2 to predict chronic periodontitis

Background  

DNA methylation of certain genes frequently occurs in neoplastic cells. Although the cause remains unknown, many genes have been identified with such atypical methylation in neoplastic cells. The hypermethylation of E-Cadherin and Cyclooxygenase 2 (COX-2) in chronic inflammation such as chronic periodontitis may demonstrate mild lesion/mutation epigenetic level. This study compares the hypermethylation status of E-Cadherin and COX-2 genes which are often found in breast cancer patients with that in chronic periodontitis.     

长期应用埃索美拉唑是维持已愈合糜烂性食管炎疗效及控制胃食管反流症状的有效方法

要确保糜烂性食管炎的治愈效果 ,长期抑制胃酸是一项必要措施。在不使用维持治疗时 ,已治愈的反流性或溃疡性食管炎 ,在 1年左右有近 80 %的病人会再出现食管黏膜的破损。 1年中奥美拉唑 2 0ｍｇ或兰索拉唑 30ｍｇ每天 1次治疗 ,可使复发率降至 30 %或更低。Ｈ2 受体阻滞剂 (Ｈ2 ＲＡ)维持治疗的效果不及ＰＰＩ。Ｈ2 ＲＡ 1年维持治疗的效果约为 50 %。奥美拉唑的Ｓ 异构体———埃索美拉唑是第一个发展为同分光学异构体的质子泵抑制剂 (ＰＰＩ)。埃索美拉唑 2 0或40ｍｇ剂量的血浆浓度时间曲线下面积 (ＡＵＣ值 )明显大于奥美拉唑 2 0ｍｇ …     

Review article: Interventions for people presenting to emergency departments with a mental health problem: A systematic scoping review

The number of people presenting to EDs with mental health problems is increasing. To enhance and promote the delivery of safe and efficient healthcare to this group, there is a need to identify evidence‐based, best‐practice models of care. This scoping review aims to identify and evaluate current research on interventions commenced or delivered in the ED for people presenting with a mental health problem. A systematic search of eight databases using search terms including emergency department, mental health, psyc* and interventions, with additional reference chaining, was undertaken. For included studies, level of evidence was assessed using the NHMRC research guidelines and existing knowledge was synthesised to map key concepts and identify current research gaps. A total of 277 papers met the inclusion criteria. These were grouped thematically into seven domains based on primary intervention type: pharmacological (n = 43), psychological/behavioural (n = 25), triage/assessment/screening (n = 28), educational/informational (n = 12), case management (n = 28), referral/follow up (n = 36) and mixed interventions (n = 105). There was large heterogeneity observed as to the level of evidence within each intervention group. The interventions varied widely from pharmacological to behavioural. Interventions were focused on either staff, patient or institutional process domains. Few interventions focused on multiple domains (n = 64) and/or included the patient's family (n = 1). The effectiveness of interventions varied. There is considerable, yet disconnected, evidence around ED interventions to support people with mental health problems. A lack of integrated, multifaceted, person‐centred interventions is an important barrier to providing effective care for this vulnerable population who present to the ED.     

Renovascular hypertension—experience of surgical and percutaneous vascular intervention in our institution

Indian Journal of Thoracic and Cardiovascular Surgery -     

Release of cytokines, soluble cytokine receptors, and interleukin-1 receptor antagonist after intravenous immunoglobulin administration in vivo

We investigated the in vivo effects of one bolus injection (400 mg/kg) of intravenous immunoglobulin (IVIG) on a number of cytokines, soluble cytokine receptors, and interleukin-1 receptor antagonist (IL-1Ra) in plasma in 12 patients with primary hypogammaglobulinemia. A significant and rapid increase in plasma levels of IL-6, IL-8, and tumor necrosis factor alpha (TNF alpha) was seen within 1 hour after IVIG infusion. This increase was accompanied by a more prolonged elevation in levels of both types of soluble TNF receptors (sTNFRs), which remained elevated throughout the study period (44 hours) although they reached peak levels within 1 hour. After an initial increase in the ratio between TNF alpha and sTNFRs, this ratio decreased to values significantly lower than baseline values 20 and 44 hours postinfusion with approximately 600-fold molar excess of sTNFRs to TNF alpha (trimer). Although only a modest but statistically significant increase in plasma levels of IL-1 beta was seen, IVIG infusion was followed by a marked increase in plasma levels of IL-1Ra with 1,000-fold molar excess of IL-1Ra to IL-1 beta in some patients. The demonstrated effects of IVIG infusion on the cytokine network, particularly the induction of IL- 1Ra and sTNFRs release, might be important for the therapeutic effects of IVIG in several immune-mediated disorders.     

Stature estimation from the length of the sternum in South Indian males: A preliminary study

Estimation of stature is one of the important initial steps during forensic analysis of human skeletal remains. The aim of the present study was to derive a linear regression formula for estimating stature of adult South Indian males from the length of the sternum. The study included 35 male sternums of South Indian origin dissected from cadavers during medico-legal autopsies. The linear regression equation [Stature = 117.784 + (3.429 × Sternal length)] was derived to estimate the stature from the length of the sternum. The correlation coefficient was 0.638. The standard error of the estimate was 5.64 cm. This preliminary study concludes that the length of the sternum can be used as a tool for stature estimation in adult South Indian males.