Black-white disparity in physical performance among older women with newly diagnosed non-metastatic breast cancer: Exploring the role of inflammation and physical activity

Objective

To examine racial differences in physical performance among older women with newly diagnosed non-metastatic breast cancer and identify clinical, behavioral and biological factors that might contribute to such disparities.

Psychotropic medicine beliefs,side effects and adherence in schizophrenia: a patient–caregiver dyad perspective

Background Medication adherence is essential in the management of schizophrenia. Yet poor treatment uptake has negative consequences on patients and their primary caregivers. Objective To examine the association among beliefs about psychotropic medications, side effects and adherence from a patient-caregiver dyad perspective. Setting This study was conducted in a public psychiatric hospital setting in Accra, Ghana. Methods A cross-sectional study was conducted among 121 patient-caregiver dyads using an interviewer-administered data collection approach.Main outcome measure Beliefs about medicines, side-effects and medication adherence. Results The patient and caregiver-reported level of medication adherence was 28.1?%. Using the Kappa index, the level of agreement between the responses of patients and their caregivers ranged from slight to moderate. Both patients and caregivers rated necessity higher than concern (patients: 1.67?±?0.84, caregiver: 1.79?±?0.96). Significant positive relations between specific-necessity, necessity–concerns differential and medication adherence were recorded while specific–concern, general harm and side-effects correlated negatively with medication adherence from the dyad. The odds of adhering to medications increased by 58 and 64?% for each unit increase in specific-necessity and general overuse scores respectively. However, a unit increase in specific–concern score and high side-effects scores were associated with lower odds of adherence. Conclusions This study highlights the need for patient-caregiver collaborations in decision-making relating to medication adherence in schizophrenia. Thus, in clinical practice, there is the need to recognize that caregivers are essential partners, and patient-caregiver views about psychotropic medications are critical in enhancing adherence for positive mental health outcomes.

     

An Analysis of Family Dynamics on High School Adolescent Risky Behaviors in Ghana

This study examined the relationship between family dynamics and student engagement in consumption of alcohol, smoking of cigarettes, and use of illicit drugs in Ghana, West Africa. Adolescents who reported that their parents consumed alcohol were more likely to do likewise. Parental consumption of alcohol increased the adolescent probability of doing the same irrespective of the gender. Adolescence is a formative period during which health risk behaviors may be learned and solidified. Policies and subsequent interventions to address health risk behaviors should not be limited to school setting. Parental engagement and monitoring outside of school significantly mediates the extent to which students engage in health risk behaviors.     

Frequency of ABO/Rhesus (D) blood groupings and ethnic distribution in the Greater‐Accra region of Ghana,towards effective blood bank inventory

Knowledge on blood group phenotypes is of key importance in clinical practice. It used in blood transfusion practice to determine the direction of recruitment of voluntary donors as required for each population within a country, and for disease association and population genetics studies. This study aimed at reporting the frequency of ABO and Rhesus (Rh) groups in the population of the Greater‐Accra region of Ghana and amongst their various ethnic groups. A retrospective study in 11 main hospitals within the region was done. Data collected provided information on the blood group status of persons (both blood donors and recipients) who visited the selected hospitals. Medical records used were within the years 2012–2017. A total of 42,317 (26,802 males and 15,515 females) data were retrieved and analysed. The frequencies of the blood groups O, A, B and AB were 50.0%, 24.3%, 20.7% and 5.0%, respectively. Rhesus‐positive to negative ratio was 93.2%/6.2%. Frequencies of blood group O was highest (49.1%–53.6%) in all ethnic groups. The second most dominant blood group was B (24.2%–25.4%) in the Ga‐Adamgbe, Akan and Ewe ethnic groups, whilst blood group A (25.0%–26.9%) was the second most dominant in the Northerners and non‐Ghanaians. Blood group distribution amongst gender and different age groups showed no significant differences but followed the same pattern for the general population. The study provides data on the ethnic distribution and frequency of ABO and Rhesus blood groupings in the Greater‐Accra region of Ghana. It also informs the need for blood banks in the region to increase the proportion of stockpiled Rhesus‐positive blood groups especially for O, B and A that may be high in demand.