Preliminary Clinical Study on Perforating Prosthokeratoplasty

Purpose:To observe the effects of perforating prosthokeratoplasty on patients with leucoma who failed in keratoplasty or were not suitable for keratoplasty, and improved their vision.Methods:Five cases with leucoma (4 with chemical burn and 1 with blast) received Yakimenko Style keratoprosthesis implantation. Preoperative examination showed the visual acuity in 4 of the 5 cases was light perception, and that of the other one was FC/20 cm. The light orientation in 3 patients was definite, and that in the other two was indefinite.Results:The vision improved in 4 of 5 patients in the follow-up period of 9 months to 3 years. Their visual acuity showed 0.09 to 0.8. And there was no change of vision in the other 1 case.Conclutions:Prosthokeratoplasty is the first choice for rehabilitation of the blind that have leucoma but are not suitable for or failed in penetrating keratoplasty. Eye Science 2003;19:146-149.     

Sites of Acetylation of Sickle Cell Hemoglobin by Aspirin

Aspirin acetylates a variety of sites on both the alpha and beta chains of hemoglobin S. Nevertheless, the vast majority of acetyl groups become attached to three loci: betaLys 59, betaLys 144, and alphaLys 90. These observations reveal some molecular details of this transacylation reaction and suggest interesting possibilities for its extension to other acylsalicylates with a variety of different structures.     

穿透人工角膜植入术的初步临床观察

目的 应用穿透人工角膜植入术使角膜移植失败或难以进行角膜移植的角膜白斑患者脱盲。方法 应用Yakimenko型人工角膜对4例化学烧伤后角膜白斑和1例爆炸伤后的角膜白斑进行了穿透人工角膜植入术。术前3例光定位准确，2例光定位不准确。结果 术后1眼视力无变化。4眼视力有不同程度的提高(0．09～0．6)、其中最好的1例术后裸眼视力为0．6，矫正视力为0．8，观察时间9个月～3年。结论 应用耳软骨加固人工角膜植床是一个行之有效的方法，对不能行角膜移植和角膜移植失败但尚存光感的角膜白斑患者，穿透人工角膜植入术是目前首选的复明手术。