Drug Alert Experience and Salience during Medical Residency at Two Healthcare Institutions

Background  Drug alerts are clinical decision support tools intended to prevent medication misadministration. In teaching hospitals, residents encounter the majority of the drug alerts while learning under variable workloads and responsibilities that may have an impact on drug-alert response rates. Objectives  This study was aimed to explore drug-alert experience and salience among postgraduate year 1 (PGY-1), postgraduate year 2 (PGY-2), and postgraduate year 3 (PGY-3) internal medicine resident physicians at two different institutions. Methods  Drug-alert information was queried from the electronic health record (EHR) for 47 internal medicine residents at the University of Pennsylvania Medical Center (UPMC) Pinnacle in Pennsylvania, and 79 internal medicine residents at the MetroHealth System (MHS) in Ohio from December 2018 through February 2019. Salience was defined as the percentage of drug alerts resulting in removal or modification of the triggering order. Comparisons were made across institutions, residency training year, and alert burden. Results  A total of 126 residents were exposed to 52,624 alerts over a 3-month period. UPMC Pinnacle had 15,574 alerts with 47 residents and MHS had 37,050 alerts with 79 residents. At MHS, salience was 8.6% which was lower than UPMC Pinnacle with 15%. The relatively lower salience (42% lower) at MHS corresponded to a greater number of alerts-per-resident (41% higher) compared with UPMC Pinnacle. Overall, salience was 11.6% for PGY-1, 10.5% for PGY-2, and 8.9% for PGY-3 residents. Conclusion  Our results are suggestive of long-term drug-alert desensitization during progressive residency training. A higher number of alerts-per-resident correlating with a lower salience suggests alert fatigue; however, other factors should also be considered including differences in workload and culture.     

Sarcoidosis of the Head and Neck

Sarcoidosis is a complex disorder that often times involves the head and neck. Despite the presence of strong clinical evidence, tissue diagnosis and imaging is needed for confirmation of the disease. Although typically managed medically, when found in the sinonasal tract or intracranially, it may necessitate the intervention of a rhinologist-skull base surgeon. This article seeks to provide a comprehensive review of head and neck sarcoidosis, as this fascinating disorder often poses a diagnostic and therapeutic challenge. A brief discussion of surgical treatment for pituitary lesions is also provided. Articles from 1997 to 2013 were selected and reviewed by three researchers utilizing the most recent literature regarding sarcoidosis in the head and neck. PubMed searches were conducted using search terms such as “sarcoidosis”, “neurosarcoid”, and “extra-pulmonary sarcoid”, among many others. A large collection of articles was generated and reviewed by the team of authors, and appropriate information was extracted to compose a thorough and expansive review of the subject. 10–15 % of patients with sarcoidosis have head and neck manifestations. Sinonasal and pituitary sarcoidosis presents a diagnostic challenge owing to its non-specific symptoms. Although systemic steroid therapy is often the first time treatment, endoscopic surgery is commonly used to treat advanced pituitary sarcoidosis refractory to medical management. As tissue diagnosis and imaging is key, a multi-disciplinary team approach is advantageous. Our study collates the available literature on head and neck sarcoidosis to provide a comprehensive review of the subject. This provides helpful information to guide all practitioners involved in the care of these challenging patients, namely pathologists, radiologists, otolaryngologists, and skull base surgeons, in the workup and management of head and neck sarcoidosis.     

Long-term drug delivery using implantable electrospun woven polymeric nanotextiles

A woven nanotextile implant was developed and optimized for long-term continuous drug delivery for potential oncological applications. Electrospun polydioxanone (PDS) nanoyarns, which are twisted bundles of PDS nanofibres, were loaded with paclitaxel (PTX) and woven into nanotextiles of different packing densities. A mechanistic modeling of in vitro drug release proved that a combination of diffusion and matrix degradation controlled the slow PTX-release from a nanoyarn, emphasizing the role of nanostructure in modulating release kinetics. Woven nanotextiles, through variations in its packing density and thereby architecture, demonstrated tuneable PTX-release. In vivo PTX-release, pharmacokinetics and biodistribution were evaluated in healthy BALB/c mice by suturing the nanotextile to peritoneal wall. The slow and metronomic PTX-release for 60 days from the loosely woven implant was extremely effective in enhancing its residence in peritoneum, in contrast to intraperitoneal injections. Such an implantable matrix offers a novel platform for therapy of solid tumors over prolonged durations.     

Inter- and intraobserver variability of radiographic measurements of knee alignment.

To evaluate the variability of radiographic measurement of knee alignment by different observers, as well as repeated measurements by the same observer, standing anteroposterior radiographs of both knees of 36 patients presenting with knee pain were analyzed. Four physicians independently measured the anatomic tibiofemoral angle of both knees for a total of 72 measurements for each observer. These measurements were then repeated 1 month later in a random and blinded fashion. The same handheld goniometer was used for all measurements. The second measurement was within 3.1 degrees of the first measurement 95% of the time, and within 4 degrees 98% of the time. The maximum difference was 6 degrees. Among all four observers, measurements were within 3.7 degrees of each other 95% of the time with a maximum difference of 6 degrees. In addition to radiographic measurement, one physician also performed clinical measurement of knee alignment on these 36 patients using the same handheld goniometer. The clinical measurement was within 5 degrees of the same clinician's radiographic measurement 95% of the time with a maximum difference of 7 degrees. This variability in measuring radiographic alignment should be considered when making decisions on the need for surgical intervention or when evaluating results of procedures that relate to coronal plane alignment of the knee.     

Comparison of SNAP<Superscript>™</Superscript> II and BIS Vista indices during normothermic cardiopulmonary bypass under isoflurane anesthesia

Objective  

Processed EEG monitoring during cardiopulmonary bypass (CPB) may help determine loss of consciousness and depth of anesthesia. This study compared the SNAP^™ II and BIS Vista monitors in patients undergoing isoflurane anesthesia with normothermic CPB.     

Radiographic comparison of sagittal plane stability between cast and boots

BACKGROUND: The importance of postoperative stability when considering surgery on the foot and ankle cannot be overestimated. To our knowledge, no literature exists to describe the radiographic sagittal plane motion with varying types of immobilization devices. The purpose of this study was to evaluate the sagittal plane range of motion allowed in different types of boots in comparison to fiberglass cast treatment on normal human subjects. MATERIALS AND METHODS: Ten healthy volunteers without preexisting foot and ankle pathology were chosen for the study. Five types of immobilization were selected for testing, including 4 off-the-shelf braces and a fiberglass cast. Maximum dorsiflexion and maximum plantarflexion lateral radiographs were taken without any immobilization and in the fiberglass cast and all walkers. RESULTS: The mean range of motion in a fiberglass cast was 8.4 degrees (SD, 4.3 degrees); FP Foam Walker, 16 degrees (SD, 6.7 degrees); XP Pneumatic Walker, 15.4 degrees (SD, 5.6 degrees); Donjoy Max Walker, 19.1 degrees (5.4 degrees); and the SP Walker, 39 degrees (SD, 10.7 degrees). The cast was noted to have a significantly greater limitation of sagittal plane motion compared to all other forms of immobilization (p < 0.05). CONCLUSION: Sagittal plane motion is restricted significantly more with a fiberglass cast compared to the FP Foam Walker, and XP Pneumatic Walker, Donjoy Max Walker, and the SP Walker. Therefore, in patients whom maximum restriction of sagittal plane motion is required, use of a fiberglass cast offers superior control.     

Fresh osteochondral total ankle allograft transplantation for the treatment of ankle arthritis

BACKGROUND: Fresh osteochondral total ankle allograft transplantation has been reported in the literature with survival rates between 50% and 92% at 1- to 12-years followup. The goal of this study was to present the results of total ankle allografts from another institution. MATERIALS AND METHODS: Twenty-nine patients underwent osteochondral total ankle transplant at our institution between July 2003 and July 2005. The mean patient age was 41 years old and the mean followup duration was 2 years. RESULTS: At followup, 14 of the 29 transplants had been revised to a repeat ankle transplant, prosthetic total ankle arthroplasty, or bone block arthrodesis. In addition, 6 of the remaining 15 transplants were deemed to be radiographic failures due to allograft fracture, allograft collapse, or progressive loss of joint space. The remaining 9 allografts (31%) were considered successes. In comparing the success versus the failure group, patients who were older, who had a lower body-mass index, and who had minimal preoperative angular deformity did significantly better. CONCLUSION: This is the largest series of osteochondral total ankle allograft transplants reported in the literature to date. There is an extremely high rate of failure associated with this procedure, and we currently consider it only rarely in patients who are too young for ankle replacement, have excellent range of motion, low body mass index, normal radiographic alignment, and who refuse arthrodesis.