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51.
Our purpose was to assess the effect of prenatal smoking interventions on rates of smoking cessation. A total of 37 trials, conducted between 1976 and 2002 and comprising over 14000 women were identified and included in the meta-analyses. There was a significant increasing in the odds of women who quit smoking in late pregnancy in the intervention group (OR = 1.6; 95% CI 1.4-1.8). The effectiveness of the intervention was significantly higher in the studies that smoking cessation intervention included written materials for pregnant women then in the studies without those materials. The percentage of pregnant women who quit smoking was higher among American women than among women from the European Countries. 相似文献
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Hypertonic resuscitation of hemorrhagic shock upregulates the anti-inflammatory response by alveolar macrophages 总被引:12,自引:0,他引:12
BACKGROUND: Resuscitated hemorrhagic shock predisposes patients to the development of acute respiratory distress syndrome (ARDS). Hypertonic saline (HTS) has been shown to inhibit immune cell activation in response to lipopolysaccharide (LPS) in vitro and to reduce lung damage when used for resuscitation of hemorrhagic shock in vivo. We hypothesize that HTS resuscitation of hemorrhagic shock may exert this anti-inflammatory effect by modulating alveolar macrophage function leading to an altered balance between the proinflammatory and the counter-inflammatory response. METHODS: A 2-hit rat model of shock resuscitation was used. Alveolar macrophages were harvested by bronchoalveolar lavage (BAL), and tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 were quantified in the cell culture supernatants by enzyme-linked immunosorbent assay (ELISA). Alternatively, 1 hour after resuscitation, animals received endotracheal LPS followed by endotracheal anti-IL-10 neutralizing antibody. Lung injury was determined by measuring BAL neutrophil counts 4 hours after LPS in vivo administration. RESULTS: Systemic administration of HTS significantly modulates the responsiveness of alveolar macrophages. Specifically, HTS resuscitation inhibited LPS-induced TNF-alpha production while enhancing IL-10 release in response to LPS administered ex vivo and in vivo. Anti-IL-10 antibody in vivo partially reversed the lung protective effect of HTS resuscitation. CONCLUSIONS: HTS resuscitation exerts an immunomodulatory effect on alveolar macrophages by shifting the balance of pro- and counter-inflammatory cytokine production in favor of an anti-inflammatory response. The in vivo data suggest a causal role for HTS-induced augmented IL-10 as protective. These findings suggest a novel mechanism for the in vivo salutary effect of HTS resuscitation on lung injury after resuscitated hemorrhagic shock. 相似文献
54.
AbstractEndometriosis is a common disease in women of reproduction age. It causes pain and difficulty in getting pregnant. However the exact causes of infertility associated with endometriosis still remain controversial. The treatment of endometriosis consists of medical treatment of pain as well as medical and surgical treatment of infertility caused by endometriosis and assisted reproduction techniques. Since the treatment of endometriosis is often connected with diminishing ovarian reserve, the techniques for ovarian tissue preservation and oocyte and embryo freezing are used to maintain the ability for childbearing. 相似文献
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Stanislaw Klek Jerzy Salowka Ryszard Choruz Tomasz Cegielny Joanna Welanyk Mariusz Wilczek Kinga Szczepanek Magdalena Pisarska-Adamczyk Michal Pedziwiatr 《Nutrients》2021,13(6)
Background and Aims: An enterocutaneous fistula (ECF) poses a major surgical problem. The definitive surgical repair of persistent fistulas remains a surgical challenge with a high rate of re-fistulation and mortality, and the reasons for that is not the surgical technique alone. Enhanced Recovery after Surgery (ERAS®) is an evidence-based multimodal perioperative protocol proven to reduce postoperative complications. The aim of the study was to assess the clinical value of the ERAS protocol in surgical patients with ECF. Methods: ERAS protocol was used in all patients scheduled for surgery for ECF at the Stanley Dudrick’s Memorial Hospital in Skawina between 2011 and 2020. A multidisciplinary team (MDT) was in charge of the program and performed annual audits. A consecutive series of 100 ECF patients (44 females, 56 males, mean age 54.1 years) were evaluated. Postoperative complications rate, readmission rate, length of hospital stay, prevalence of postoperative nausea and vomiting were assessed. Registered under ClinicalTrials.gov Identifier no. . Results: ERAS protocol was successfully introduced for ECF surgeries; however, eight modifications to the ERAS program was performed in 2015. They led to improvement of surgical outcomes: reduction of postoperative nausea and vomiting (15 vs. 17% patients, p = 0.025), overall complication rate (11 vs. 10, p = 0.021), median length of hospital stay (overall and after surgery, p = 0.022 and 0.002, respectively). Conclusions: ERAS protocol can be successfully used for ECF patients. Prescheduled audits can contribute to the improvement of care. NCT04771832相似文献
57.
Kinga Morsanyi Simon J. Handley Jonathan S. B. T. Evans 《Journal of autism and developmental disorders》2010,40(11):1378-1388
The conjunction fallacy has been cited as a classic example of the automatic contextualisation of problems. In two experiments
we compared the performance of autistic and typically developing adolescents on a set of conjunction fallacy tasks. Participants
with autism were less susceptible to the conjunction fallacy. Experiment 2 also demonstrated that the difference between the
groups did not result from increased sensitivity to the conjunction rule, or from impaired processing of social materials
amongst the autistic participants. Although adolescents with autism showed less bias in their reasoning they were not more
logical than the control group in a normative sense. The findings are discussed in the light of accounts which emphasise differences
in contextual processing between typical and autistic populations. 相似文献
58.
Niguldipine impairs the protective activity of carbamazepine and phenobarbital in amygdala-kindled seizures in rats. 总被引:2,自引:0,他引:2
Kinga K Borowicz Zdzislaw Kleinrok Stanislaw J Czuczwar 《European neuropsychopharmacology》2002,12(3):225-233
There is evidence that some calcium (Ca(2+)) channel inhibitors enhance the protective activity of antiepileptic drugs. Since clinical trials have not provided consistent data on this issue, the objective of this study was to evaluate the interaction of a dihydropyridine, niguldipine, with conventional antiepileptics in amygdala-kindled rats. Niguldipine (at 7.5 but not at 5 mg/kg) displayed a significant anticonvulsant effect, as regards seizure and afterdischarge durations in amygdala-kindled convulsions in rats, a model of complex partial seizures. No protective effect was observed when niguldipine (5 mg/kg) was combined with antiepileptics at subeffective doses, i.e. valproate (75 mg/kg), diphenylhydantoin (40 mg/kg), or clonazepam (0.003 mg/kg). Unexpectedly, the combined treatment of niguldipine (5 mg/kg) with carbamazepine (20 mg/kg) or phenobarbital (20 mg/kg) resulted in a proconvulsive action. BAY k-8644 (an L-type Ca(2+) channel activator) did not modify the protective activity of niguldipine (7.5 mg/kg) or the opposite action of this dihydropyridine (5 mg/kg) in combinations with carbamazepine or phenobarbital. A pharmacokinetic interaction is not probable since niguldipine did not affect the free plasma levels of the antiepileptics. These data indicate that the opposite actions of niguldipine alone or combined with carbamazepine (or phenobarbital) were not associated with Ca(2+) channel blockade. The present results may argue against the use of niguldipine as an adjuvant antiepileptic or for cardiovascular reasons in patients with complex partial seizures. 相似文献
59.
Kinga Musiał Krystyna Szprynger Maria Szczepańska Danuta Zwolińska 《Pediatric nephrology (Berlin, Germany)》2009,24(10):2029-2034
Chronic inflammation, lipid and autoimmune disorders are hallmarks of atherogenesis, and hemodialysis per se may be an additional
factor predisposing to accelerated atherosclerosis. Elevated levels of heat shock proteins (HSP) and antibodies against these
HSP have been described in adults with atherosclerotic lesions and cardiovascular events, but to date there has been a scarcity
of investigations on these parameters in adult and pediatric patients on hemodialysis (HD). We have investigated the HSP profile
in hemodialyzed children and the impact of a single HD session on those proteins and their correlations with known risk factors
for atherosclerosis. The study group consisted of 17 children and young adults undergoing HD with polysulfone membranes. The
control group comprised 15 age-matched subjects with normal kidney function. The serum concentrations of Hsp60, Hsp90alpha,
anti-Hsp60, anti-Hsp70, and sE-selectin were assessed by an enzyme-linked immunosorbent assay, and serum concentration of
high-sensitivity-C-reactive protein was assayed by nephelometry. The serum lipid profile [total cholesterol (CHOL), high-density
lipoprotein-CHOL, low-density lipoprotein-CHOL, triglycerides] was also estimated. Compared to the control values, the median
values of Hsp60 before the HD session were lower, whereas those of Hsp90alpha and anti-Hsp60 were higher. A single HD session
raised the median values of Hsp60 and Hsp90alpha and decreased the concentrations of anti-Hsp60 and anti-Hsp70. In addition,
the concentrations of HSPs and the antibodies against them correlated with the lipid markers both before and after HD. The
altered HSP and anti-HSP concentrations in HD children, which correlated with the lipid profile and the endothelial markers,
suggest a dysfunctional HSP system in this population and the possibility of HSPs being classified as new markers of atherosclerosis. 相似文献
60.
Ronan Thibault Anne-Marie Makhlouf Aurélien Mulliez M. Cristina Gonzalez Gintautas Kekstas Nada Rotovnik Kozjek Jean-Charles Preiser Isabel Ceniceros Rozalen Sylvain Dadet Zeljko Krznaric Kinga Kupczyk Fabienne Tamion Noël Cano Claude Pichard Phase Angle Project Investigators 《Intensive care medicine》2016,42(9):1445-1453