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Ireneusz Całkosiński Jacek Majda Grzegorz Terlecki Kinga Gostomska-Pampuch Katarzyna Małolepsza-Jarmołowska Sylwia Sobolewska Aleksandra Całkosińska Aleksandra Kumala Andrzej Gamian 《Inflammation》2016,39(3):1076-1089
A significant role is played in inflammation by the liver, which, stimulated by inflammatory mediators, synthetizes plasma proteins with various dynamics. The purpose of these studies is to generate a detailed dynamic analysis of changes to concentrations of plasma and serum protein fractions and selected acute-phase proteins as well as nonspecific biochemical indices during the course of an induced pleurisy. The studies were conducted on female inbred Buffalo rats, which were divided into two groups: a control group (C) and an experimental group (IP) in which pleurisy was induced. In the IP group, significant changes in biochemical indices were observed between the 48th and 96th hours of pleurisy. A reduction of albumin, transferrin, urea, and creatinine concentrations was observed, while concentrations of the complement components C3 and C4, haptoglobin, and fibrinogen increased. An early increase of IL-1 was observed, while increases of IL-6 and TNF were noted in the later period. The maximum intensity of the processes described above occurred between the 72nd and 96th hours of pleurisy. 相似文献
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Karolina Kowalska Marta Justyna Kozie Kinga Anna Urbanek Dominika Ewa Habrowska-Grczyska Kamila Domiska Agnieszka Wanda Piastowska-Ciesielska 《Toxins》2021,13(11)
Alternaria toxins are considered as emerging mycotoxins, however their toxicity has not been fully evaluated in humans. Alternariol (AOH), the most prevalent Alternaria mycotoxin, was previously reported to be genotoxic and to affect hormonal balance in cells; however, its direct molecular mechanism is not known. The imbalance in androgen/estrogen ratio as well as chronic inflammation are postulated as factors in prostate diseases. The environmental agents affecting the hormonal balance might participate in prostate carcinogenesis. Thus, this study evaluated the effect of two doses of AOH on prostate epithelial cells. We observed that AOH in a dose of 10 µM induces oxidative stress, DNA damage and cell cycle arrest and that this effect is partially mediated by estrogen receptor β (ERβ) whereas the lower tested dose of AOH (0.1 µM) induces only oxidative stress in cells. The modulation of nuclear erythroid-related factor 2 (Nrf2) was observed in response to the higher dose of AOH. The use of selective estrogen receptor β (ERβ) inhibitor PHTPP revealed that AOH-induced oxidative stress in both tested doses is partially dependent on activation of ERβ, but lack of its activation did not protect cells against AOH-induced ROS production or DNA-damaging effect in case of higher dose of AOH (10 µM). Taken together, this is the first study reporting that AOH might affect basic processes in normal prostate epithelial cells associated with benign and malignant changes in prostate tissue. 相似文献
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Due to the high cost of experiments commonly performed to verify the resistance of glass elements to impact loads, numerical models are used as an alternative to physical testing. In these, accurate material parameters are crucial for a realistic prediction of the behaviour of glass panels subjected to impact loads. This applies in particular to the glass’s strength, which is strictly dependent on the strain rate. The article reports the results of an extensive experimental campaign, in which 185 simply supported toughened glass samples were subjected to hard-body impacts. The study covers a wide range of glass thicknesses (from 5 to 15 mm), and it aims to determine a critical drop height causing fracture of the glass. Moreover, a 3D numerical model of the experimental set-up was developed to reproduce the experiments numerically and retrospectively to determine the peak stress in glass that developed during the impact. Based on the results of numerical simulations, a load duration factor of 1.40 for toughened glass for impact loads is proposed. In addition, the paper includes a case study to demonstrate the use of the modelling methodology and results of the work on a practical example of an internal glass partition wall. 相似文献
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Ruth C. Angrand Rhoda Sperling Kinga Roccobono Lauren M. Osborne Jennifer Jao 《AIDS care》2018,30(9):1168-1172
“Depression (as noted in chart by a physician)” was compared between HIV infected pregnant women and controls. Perinatally HIV-infected (PHIV), non-perinatally HIV-infected (NPHIV), and HIV-uninfected (HIV-U) pregnant women were all compared using a logistic regression model. Overall, HIV-infected women had higher rates of depression than HIV-U, with PHIV women demonstrating a clinically and statistically significant increased risk compared to HIV-U women [adjusted OR: 15.9, 95% CI?=?1.8–143.8]. Future studies in larger populations are warranted to confirm these findings and further elucidate mental health outcomes of PHIV and NPHIV pregnant women. 相似文献
108.
Sagar Rohailla Ann Kinga Malinowski Shital Gandhi Anne McLeod Rosane Nisenbaum Nadine Shehata 《Journal d'obstetrique et gynecologie du Canada》2018,40(7):888-895.e6
Objective
This study sought to determine whether there is practice variation in the treatment and prevention of acute venous thromboembolism (VTE) in pregnant patients, potentially to prioritize future studies.Background
The risk of VTE during pregnancy is five-fold that of the non-pregnant state. Guidance is often lacking for the treatment and prophylaxis of VTE because there are few RCTs.Methods
The study used a cross-sectional study design using a self-administered electronic questionnaire consisting of 11 case scenarios that were sent to hematologists, maternal-fetal medicine specialists, obstetricians and gynaecologists, and internal medicine specialists across Canada.Results
A total of 254 participants responded to the survey and 193 (76%) completed the survey, 158 of whom indicated that they were involved in the decision to anticoagulate these patients. Anticoagulation of patients with superficial venous thrombosis during pregnancy, monitoring of low-molecular-weight heparin antepartum, and discontinuation of this agent at the time of delivery were the scenarios associated with the largest variability of responses. For the management of acute VTE antepartum, most participants favoured a once-daily regimen, although internists more so than obstetrics and gynaecology physicians (94.7% vs. 73.7%). Cesarean section was not perceived to be a procedure with a marked increased risk of thrombosis to warrant thromboprophylaxis because most physicians elected not to offer thromboprophylaxis for this scenario. However, obesity and severe preeclampsia with Cesarean section led to the predominant use of thromboprophylaxis, at 80.0% and 68.4%, respectively.Conclusion
Prospective studies addressing peripartum management where significant discrepancies exist are warranted. 相似文献109.
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Marta Marszalek-Grabska Ewa Gibula-Bruzda Anna Bodzon-Kulakowska Piotr Suder Kinga Gawel Joanna Filarowska Joanna Listos Wojciech Danysz Jolanta H. Kotlinska 《Neurotoxicity research》2018,33(3):607-620
Glutamate is essential for learning and memory processes, and acute and chronic exposures to ethanol (or protracted abstinence) alter glutamatergic transmission. In the current study, we investigated the effects of VU-29, positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor, on the acute ethanol- and ethanol withdrawal-induced impairment of novel object recognition (NOR) task in rats. The influence of VU-29 (30 mg/kg) on memory retrieval was measured (a) at 4-h delay after acute ethanol administration, as well as (b) after acute withdrawal (24 and 48 h) of repeated (2.0 g/kg, once daily for 7 days) ethanol administration. Additionally, the effects of VU-29 on expression of mGlu5 and mGlu2 receptor proteins in the hippocampus, prefrontal cortex, and striatum were determined 48 h after ethanol withdrawal. Our results indicated that VU-29, given before acute ethanol administration, prevented the ethanol-induced impairments in spatial memory retrieval. Furthermore, VU-29 given before the testing session on the first day of abstinence facilitated NOR performance in ethanol-withdrawn rats at 4- and 24-h delay after administration. Our ELISA results show that VU-29 normalized ethanol withdrawal induced increase in expression of mGlu5 receptor protein in the hippocampus, prefrontal cortex, and striatum, as well as expression of mGlu2 receptor protein in the hippocampus. Thus, results from our study indicate that positive modulation of mGlu5 receptor prevented and reversed ethanol-induced memory impairment. Moreover, mGlu5 (hippocampus, prefrontal cortex, and striatum) and mGlu2 (hippocampus) receptors play an important role in the ethanol-induced recognition memory impairment induced by ethanol withdrawal. 相似文献