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61.
62.
Yuko Hayashi Nobuhiro Suzumori Tokio Sugiura Mayumi Sugiura‐Ogasawara 《Congenital anomalies》2015,55(3):161-163
Holoprosencephaly (HPE) is a rare brain abnormality characterized by an incomplete cleavage of the primitive prosencephalon of forebrain during early embryogenesis. To determine the clinical characteristics and outcome of fetuses with HPE, we retrospectively analyzed nine patients who were prenatally diagnosed as fetal HPE by ultrasounds. The mean diagnostic weeks were 20 weeks of gestation. Two cases died within one day after birth. The chromosomal examinations were performed in seven cases (trisomy 18: n = 2; trisomy 13: n = 2; 45,XX,der(18)t(18;21)(p10;p10)mat: n = 1; normal karyotype: n = 2). In our HPE cases, most cases had serious facial anomalies and poor prognosis. Our data suggested that the early prenatal diagnosis of HPE allowed time for parental counseling and delivery planning. 相似文献
63.
Molecular cloning and sequence analysis of the cyanobacterial gene for the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase 总被引:21,自引:3,他引:21 下载免费PDF全文
Shinozaki K Yamada C Takahata N Sugiura M 《Proceedings of the National Academy of Sciences of the United States of America》1983,80(13):4050-4054
Ribulose-1,5-bisphosphate carboxylase/oxygenase consists of large subunits (LS) and small subunits. In plants, the LS is encoded in chloroplast DNA and the small subunit, in nuclear DNA. In cyanobacteria, both subunits are thought to be encoded in chromosomal DNA because of prokaryotes. The gene for the LS of ribulose-1,5-bisphosphate carboxylase/oxygenase from a cyanobacterium, Anacystis nidulans 6301, has been cloned in pBR322 and subjected to sequence analysis. The coding region contains 1,416 base pairs (472 codons). The deduced amino acid sequence of A. nidulans LS protein shows 80% homology with sequences of maize, spinach, and tobacco LS proteins; the nucleotide sequence of A. nidulans LS gene shows 70% homology with sequences of the plant genes. Between A. nidulans LS and the plant LS proteins there is exact sequence homology around the lysine residue to which the activator CO2 binds and around the two lysine residues to which ribulose 1,5-bisphosphate binds. The amino acid sequence where the LS binds to the small subunit is also highly conserved. From comparison of the LS proteins of A. nidulans and the three plants, the rate of amino acid substitution is estimated to be 0.25-0.5 × 10-9 per year per site, which is far below the median value of various types of proteins (1.2 × 10-9 for hemoglobin α). The LS protein is thus a conserved protein. 相似文献
64.
Yoshikiyo Kanada Hiroaki Sakurai Yoshito Sugiura 《Journal of Physical Therapy Science》2015,27(3):715-718
[Purpose] The difficulty levels of level-2 OSCE (examination and measurement skills)
items were examined, with a view to providing reference data for the determination of
students’ skills. [Subjects] A total of 284 graduates of physical (PT) and occupational
(OT) therapy classes of 2011 (59 and 40), 2012 (46 and 36), and 2013 (61 and 42,
respectively) were studied, with PT or OT faculty members as OSCE examiners and a
simulated patient. [Methods] Scores for 11 level-2 OSCE items were compared between before
and after clinical training. [Results] Scores markedly increased after clinical training.
On comparison among the items, scores for sensory examination were the highest, and those
for interviews were the lowest. [Conclusion] The results of this study indicate the
necessity of considering an appropriate combination of different difficulty levels when
adopting OSCE-based educational approaches.Key words: OSCE, Clinical skill, Physical and occupational therapists 相似文献
65.
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Katsuhiko Iwakiri Hidenori Kanazawa Satoshi Matsuzaka Norihiko Tada Hitoshi Saitoh Hitoshi Yoshimoto Yoshiya Nakagawa Yuuji Osada Toshiaki Sugiura Makoto Kotoyori Yasutaka Mamiya Hisagi Yamada Yoshiyuki Narahara Akihiko Kawakami Masafumi Kobayashi 《Journal of gastroenterology》1998,33(3):305-309
The effects of transjugular intrahepatic portosystemic shunt (TIPS) placement on esophageal motor function and gastroesophageal
reflux were investigated in patients with esophageal varices. In six men with esophageal varices, esophageal manometry and
upper gastrointestinal endoscopy were performed before and 15–20 days after TIPS placement. Intraesophageal pH monitoring
was performed in the four patients with severe esophageal varices (defined as the largest sized varices) following TIPS placement.
Findings were compared with those in six healthy men (controls) who underwent esophageal manometry and intraesophageal pH
monitoring. The esophageal varices resolved or were reduced after TIPS placement. Resting lower esophageal sphincter (LES)
pressures were similar in the study group before and after TIPS placement and in the control subjects. The incidence and progression
of esophageal contractions were similar in the study group before and after TIPS placement and in the control subjects. At
3 cm above the LES, the amplitude of esophageal contraction after TIPS placement was significantly higher than that before
TIPS placement. At 3 and 8 cm above the LES, the amplitude of esophageal contraction in the control subjects was significantly
higher than that in the study group before and after TIPS placement. Esophageal acid exposure time after TIPS placement was
similar to that in the controls. TIPS placement is a useful treatment that improves esophageal motor function without the
occurrence of pathologic gastroesophageal reflux.
(Received May 28, 1997; accepted Sept. 26, 1997) 相似文献
68.
M Matsutani T Sugiura N Takahashi T Hasegawa Y Takayama T Iwasaka M Inada 《The American journal of cardiology》1988,61(15):1347-1349
69.
70.
Y. Mori F. Okazaki C. Inuo Y. Yamaguchi S. Masuda S. Sugiura T. Fukuie M. Nagao I. Tsuge T. Yosikawa A. Yagami K. Matsunaga T. Fujisawa K. Ito H. Narita Y. Kondo 《Allergologia et immunopathologia》2018,46(5):482-490