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51.
A Novel Approach to Patient Self‐Monitoring of Sonographic Examinations Using a Head‐Mounted Display
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Takagi T Matsuda M Abe M Kobayashi H Fukuhara A Komuro R Kihara S Caslake MJ McMahon A Shepherd J Funahashi T Shimomura I 《Atherosclerosis》2008,196(1):114-121
In the West of Scotland Coronary Prevention Study (WOSCOPS), treatment of hypercholesterolemic men with pravastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, reduced their likelihood to progress to diabetes mellitus by 30%. However, the mechanism of this effect of pravastatin has not been investigated. In the current study, we examined the effect of pravastatin on the development of diabetes in obese diabetic mice, and on the insulin-induced glucose uptake and adiponectin production. Pravastatin treatment attenuated the development of diabetes in db/db and high fat/high sucrose diet-fed C57BL/6J mice. An in vivo glucose transport assay showed that pravastatin upregulated glucose uptake in adipose tissue. Insulin-stimulated glucose uptake was enhanced in primary adipocytes isolated from pravastatin-treated mice. Pravastatin treatment increased adiponectin production in 3T3-L1 adipocytes. Plasma adiponectin levels were significantly increased in pravastatin-treated mice. Analyses of plasma samples from the WOSCOPS biobank indicated a significant increase of plasma adiponectin levels with pravastatin treatment (placebo -0.28+/-0.34 microg/ml versus pravastatin +1.47+/-0.33 microg/ml, p=0.0003). Taken together, our findings suggest that pravastatin may have beneficial effects on adipose tissue, which may partly explain the reduction of the development of diabetes by pravastatin treatment. 相似文献
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Takehiro Igarashi Takashi Kambe Hitoshi Kihara 《Journal of labelled compounds & radiopharmaceuticals》2019,62(12):865-869
18O‐labeled water (Water‐18O) is a widely used starting material of 18F‐labeled diagnostic agents in positron emission tomography (PET). Conventionally, Water‐18O has been separated from other stable oxygen isotope species (16O, 17O) by water distillation or nitric oxide distillation. However, conventional methods are costly and may have safety issues. In 2004, we developed the first unit of our novel oxygen isotope separation process by cryogenic oxygen distillation to overcome these issues. To meet the needs of the market, we built a second unit in 2013 and a third in 2016. We are now operating three commercially viable separation units with a total capacity of 600 kg of Water‐18O per year. 相似文献
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