全文获取类型
收费全文 | 190篇 |
免费 | 6篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 4篇 |
基础医学 | 41篇 |
口腔科学 | 7篇 |
临床医学 | 21篇 |
内科学 | 25篇 |
皮肤病学 | 8篇 |
神经病学 | 2篇 |
特种医学 | 47篇 |
外科学 | 12篇 |
综合类 | 1篇 |
预防医学 | 7篇 |
药学 | 19篇 |
肿瘤学 | 13篇 |
出版年
2023年 | 1篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 1篇 |
2016年 | 1篇 |
2015年 | 1篇 |
2014年 | 5篇 |
2013年 | 9篇 |
2012年 | 3篇 |
2011年 | 3篇 |
2010年 | 8篇 |
2009年 | 9篇 |
2008年 | 5篇 |
2007年 | 16篇 |
2006年 | 3篇 |
2005年 | 4篇 |
2004年 | 1篇 |
2002年 | 7篇 |
2001年 | 5篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1998年 | 11篇 |
1997年 | 15篇 |
1996年 | 8篇 |
1995年 | 7篇 |
1994年 | 4篇 |
1993年 | 7篇 |
1992年 | 7篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 5篇 |
1988年 | 6篇 |
1987年 | 8篇 |
1986年 | 5篇 |
1985年 | 2篇 |
1984年 | 6篇 |
1983年 | 4篇 |
1982年 | 7篇 |
1981年 | 1篇 |
1980年 | 5篇 |
1979年 | 1篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1971年 | 1篇 |
排序方式: 共有209条查询结果,搜索用时 0 毫秒
31.
32.
Jacqueline Scholl Jan Günthner Nils Kolling Elisa Favaron Matthew FS Rushworth Catherine J Harmer Andrea Reinecke 《Neuropsychopharmacology》2014,39(12):2900-2909
N-methyl-D-aspartate (NMDA) receptors are known to fulfill crucial functions in many forms of learning and plasticity. More recently, biophysical models, however, have suggested an additional role of NMDA receptors in evidence integration for decision-making, going beyond their role in learning. We designed a task to study the role of NMDA receptors in human reward-guided learning and decision-making. Human participants were assigned to receive either 250 mg of the partial NMDA agonist d-cycloserine (n=20) or matching placebo capsules (n=27). Reward-guided learning and decision-making were assessed using a task in which participants had to integrate learnt and explicitly shown value information to maximize their monetary wins and minimize their losses. To tease apart the effects of NMDA on learning and decision-making we used simple learning models. D-cycloserine shifted decision-making towards a more optimal integration of the learnt and the explicitly shown information, in the absence of a direct learning effect. In conclusion, our results reveal a distinct role for NMDA receptors in reward-guided decision-making. We discuss these findings in the context of NMDA''s roles in neuronal super-additivity and as crucial for evidence integration for decisions. 相似文献
33.
34.
1-乙基-6-氟-1,4-二氢-4-氧代-7-(4-芳酰硫代氨甲酰基-1-哌嗪基)-3-喹啉羧酸的合成及抗菌作用 总被引:3,自引:1,他引:3
Thirteen new 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroyl-thiocarbamoyl- 1 piperazinyl)-3-quinoline carboxylic acids were prepared, Their structures were characterized by elemental analysis, IR, HNMR and MS spectra.Preliminary pharmacological tests indicated that some of compounds Ia~m possess strong inhibiting activity against Escherichia coli, Bacillus subtilis and Proteus at concentration of 100 μg/ml. 相似文献
35.
36.
37.
A series of compounds was synthesized, these compounds were tested for Hela-S3cells in vitro for radiosensitizing activity. Five of them are 2,2′- (arylimino)-diethyl-sodium thio-sulfate and two of them are phenylalanine derivatives. Most of them showed various degrees of ra-diosensitizing activity. Among them, SER of L07 was 1.89 at 3 mmol, and had low cytotoxicity toHela-S3 cells;ID50 was 18.8 mmol. The relationship between radiosensitizing effects and chemicalstructure was discussed. It offers a base for further exploration of selectively hypoxic cell radiosens-itizers. 相似文献
38.
Detection of infectious bursal disease viruses by using cloned cDNA probes. 总被引:1,自引:0,他引:1 下载免费PDF全文
A molecular clone representing 445 base pairs at the 3' end of infectious bursal disease virus (IBDV) genome segment B was used in a dot blot hybridization assay to detect viral RNA from cell culture and from chicken bursa and spleen tissue specimens. The cloned nucleotide sequence represents approximately 14% of the virus-encoded polymerase (VP-1) gene. The lower detection limit of radiolabeled probes prepared from this clone was 0.1 ng of IBDV double-stranded RNA. The probe had broad specificity and was used to detect four serotype 1 IBDV strains and one serotype 2 IBDV strain. This probe, however, did not cross-react with nucleic acid extracted from nine unrelated poultry viruses. A rapid procedure for isolation of IBDV genomic RNA from bursa and spleen tissue specimens was developed and used with the dot blot hybridization assay to detect IBDV strains in tissue samples from experimentally infected and commercially reared chickens. 相似文献
39.
Daniel M Fatovich Anne Bartu Geoff Davis Jag Atrie Frank FS Daly 《Emergency medicine Australasia : EMA》2010,22(3):240-245
Introduction: To examine hospitalizations in a cohort of 224 patients who presented with non‐fatal heroin overdose to an ED. Methods: A record linkage study, using the morbidity, mental health and mortality databases in the Data Linkage Unit of the Department of Health, Western Australia. The main outcome measures were hospital separations 5 years before and after entry into the cohort. Results: Before entry into the cohort, 199 (89%) patients had an admission to mental health services. These 199 had a combined total of 1367 separations, most commonly for a mental health condition, injury or poisoning. Women had more than twice the relative risk (RR) of men for all separations (RR 2.35, 95% confidence interval [CI] 1.96–2.82, P < 0.001) and for injury and poisoning separations (RR 2.04, 95% CI 1.56–2.66, P < 0.001). The highest concentrations of separations occurred within 1 year before and 1 year after entry into the cohort. There were 12 (5.4%, 95% CI 2.9–9.4%) deaths, most commonly from overdose. Conclusion: Non‐fatal heroin overdose ED presentations are associated with a cluster of hospitalizations around that episode, likely to be related to heroin availability. Presentation to hospital by heroin users represents an opportunity to counsel less risky behaviour. 相似文献
40.
目的:分析肾移植术后常见并发症肾功能延迟恢复的诱因,并观察术后血液净化干预所发挥的临床效应。方法:选择1996—12/2006—12在解放军第三军医大学大坪医院野战外科研究所泌尿外科明确诊断为肾移植术后肾功能延迟恢复的患者193例,其中接受尸肾移植192例,活体肾移植1例,均知情同意。根据患者的临床资料,分析术后肾功能延迟恢复的主要原因。除5例因术前安置腹膜透析管继续采用腹膜透析外,其余均选择血液透析治疗,其中35例穿插接受过连续性肾脏替代治疗或血液透析滤过,8例血浆置换2-5次。终止透析的标准为每日尿量〉1500mL,血肌酐〈300μmol/L。分析术后肾功能延迟恢复的原因,观察接受透析治疗后肾功能延迟恢复患者的临床疗效。结果:193例患者全部进入结果分析。①术后肾功能延迟恢复的病因:急性肾小管坏死89例(46.1%),术后早期低血压42例(21.8%),排斥反应37例(19.2%),动静脉吻合口狭窄9例(4-7%),尿路梗阻8例(4.1%),动脉过长扭曲5例(2.6%),环孢素A肾毒性2例(1.0%),髂内动脉粥样硬化斑块阻塞1例(0.5%)。(④术后肾功能转归:移植肾功能恢复正常者145例(75.1%);术后3个月血肌酐135-300μmol/L29例(15.3%);〉300μmol/L15例(7.8%);因超急性排斥反应切除移植肾2例(1%),肺部重症感染死亡2例(1%)。③术后接受血液透析次数:术后接受血液透析189例,透析1—5次移植肾功能恢复正常20例(13.8%);6-10次41例(28.3%);11-20次82例(56.6%);21-25次2例(1.4%);〉25次44例,仅1例恢复正常(0.7%),其余43例患者带肾存活。结论:急性肾小管坏死、术后早期低血压和排斥反应是引起肾移植术后肾功能延迟恢复的主要原因。在肾功能延迟恢复患者确定以血液净化为主的方案后,绝大多数移植肾功能可以恢复。 相似文献