全文获取类型
收费全文 | 1006篇 |
免费 | 96篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 74篇 |
妇产科学 | 31篇 |
基础医学 | 96篇 |
口腔科学 | 37篇 |
临床医学 | 170篇 |
内科学 | 210篇 |
皮肤病学 | 27篇 |
神经病学 | 47篇 |
特种医学 | 156篇 |
外科学 | 73篇 |
综合类 | 26篇 |
预防医学 | 66篇 |
眼科学 | 12篇 |
药学 | 56篇 |
1篇 | |
中国医学 | 9篇 |
肿瘤学 | 51篇 |
出版年
2023年 | 2篇 |
2021年 | 9篇 |
2020年 | 8篇 |
2019年 | 6篇 |
2018年 | 22篇 |
2017年 | 24篇 |
2016年 | 26篇 |
2015年 | 28篇 |
2014年 | 36篇 |
2013年 | 44篇 |
2012年 | 18篇 |
2011年 | 30篇 |
2010年 | 41篇 |
2009年 | 68篇 |
2008年 | 28篇 |
2007年 | 47篇 |
2006年 | 19篇 |
2005年 | 25篇 |
2004年 | 11篇 |
2003年 | 16篇 |
2002年 | 10篇 |
2001年 | 21篇 |
2000年 | 14篇 |
1999年 | 23篇 |
1998年 | 72篇 |
1997年 | 82篇 |
1996年 | 57篇 |
1995年 | 51篇 |
1994年 | 37篇 |
1993年 | 43篇 |
1992年 | 14篇 |
1991年 | 9篇 |
1990年 | 12篇 |
1989年 | 26篇 |
1988年 | 22篇 |
1987年 | 27篇 |
1986年 | 14篇 |
1985年 | 20篇 |
1984年 | 11篇 |
1983年 | 14篇 |
1982年 | 10篇 |
1981年 | 8篇 |
1980年 | 9篇 |
1978年 | 5篇 |
1977年 | 11篇 |
1976年 | 5篇 |
1975年 | 2篇 |
1934年 | 1篇 |
1931年 | 1篇 |
1930年 | 1篇 |
排序方式: 共有1148条查询结果,搜索用时 0 毫秒
961.
962.
Heparin therapy in the Chinese--lower doses are required 总被引:1,自引:0,他引:1
Yu CM; Chan TY; Tsoi WC; Sanderson JE 《QJM : monthly journal of the Association of Physicians》1997,90(8):535-543
Warfarin requirements are lower in the Chinese, but it is not known if this
applies to heparin. We investigated the optimal dose for heparin therapy in
Chinese patients, and to assess relationship between i.v. heparin dosage
and anticoagulation efficacy. One hundred Chinese patients requiring
intravenous heparin therapy were given an initial bolus followed by
continuous intravenous infusion. The main outcome measures were: (i)
Efficacy of anticoagulation assessed by blood coagulation studies (APTT)
compared to heparin dosage, (ii) Determinants of dosage variation-age,
gender, body weight, height, indication for heparin therapy and number of
medications, other disease, and serum albumin level. It was found that the
mean therapeutic infusion dose requirement of heparin was 848.7 +/- 274.7
units/h, 79% required a dose of 1000 units/h or less. Heparin dose
correlated negatively with age (r = -0.40; p < 0.001) and positively
with weight (r = 0.44 p < 0.001) and height (r = 0.49; p < 0.001).
Chinese subjects require lower heparin doses (about 800 units/h) than
usually recommended for Caucasians (usual dose 1000-1500 units/h). This can
be partly explained by the lower body weight in Chinese patients.
相似文献
963.
L Di Alberti SR Porter PM Speight CM Scully JM Zakrzewska IG Williams L Artese A Piattelli SL Ngui CG Teo 《Oral diseases》1997,3(Z1):S133-S134
OBJECTIVE: To determine the frequency of detection of human herpesvirus-8 (HHV-8) in HIV-related oral ulcers. DESIGN: Analysis of archived biopsy material. METHODS: Nested polymerase chain reaction of DNA extracts. RESULTS: HHV-8 DNA was detected in six of 10 oral ulcers of HIV-positive patients without oral Kaposi's sarcoma (KS) lesions and five of 11 oral KS lesions. The positive non-KS samples were derived from various oral sites. CONCLUSIONS: In HIV-positive people, HHV-8 can infect oral tissues that are not affected by KS. 相似文献
964.
脂肪组织与骨骼肌信号之间的分子代谢关系 总被引:1,自引:0,他引:1
学术背景:最近研究发现脂肪组织与骨骼肌之间有着某种联系。脂肪组织能分泌许多细胞因子,对体质量调节起着重要作用。然而骨骼肌在代谢调节方面可能与脂肪组织有相似的作用。目的:探讨骨骼肌与脂肪组织之间的关系,说明骨骼肌在控制体质量方面的作用。检索策略:应用计算机检索CMBI、NCBI据库1994-01/2005-12相关骨骼肌、脂肪组织、肥胖等方面的文献,检索词"Skeletal muscle,Adipose tissue",限定文献语言种类为English。对资料进行初审,选取包括骨骼肌、脂肪组织、瘦素与细胞因子的文献,开始查找全文。纳入标准:①具有原创性,论点论据可靠的实验文章。②观点明确,分析全面的文章。③文献主体内容与此课题联系紧密的文章。排除标准:实验设计不合理的文章及观点模糊的综述。文献评价:共检索到109篇关于骨骼肌、脂肪组织与细胞因子的文献,最终纳入47篇符合标准的文献。资料综合:脂肪组织在能量稳态中起重要作用,能分泌一些细胞因子。这些细胞因子的表达或活性的改变对肥胖和胰岛素抵抗等病理状态有着重要作用。然而骨骼肌在代谢调节方面可能与脂肪组织有相似的作用。有研究证明在骨骼肌中表达的一些细胞因子确实可以调节脂肪代谢。本文综述了脂肪组织和骨骼肌信号之间的代谢关系。这两种组织的细胞因子在维持脂肪组织和骨骼肌足够比率方面有重要作用,因而在体质量控制方面亦有重要作用。白细胞介素15(在骨骼肌中高度表达)、肿瘤坏死因子α和瘦素在脂肪组织与骨骼肌之间联系中起着重要作用。结论:脂肪组织与骨骼肌之间可能存在联系,而且与体质量控制有关,包括脂肪储存和肌肉质量的控制。 相似文献
965.
Signal transduction defects in growth hormone insensitivity 总被引:2,自引:0,他引:2
PE Clayton JS Freeth AJ Whatmore RM Ayling MR Norman CM Silva 《Acta paediatrica (Oslo, Norway : 1992)》1999,88(S428):174-178
966.
Bressler SL; Gray MD; Sopher BL; Hu Q; Hearn MG; Pham DG; Dinulos MB; Fukuchi K; Sisodia SS; Miller MA; Disteche CM; Martin GM 《Human molecular genetics》1996,5(10):1589-1598
Using the yeast two hybrid system, a mouse embryo cDNA library was screened
for proteins that interact with the C-terminus of the human beta-amyloid
precursor protein (beta PP). A fusion protein was identified that interacts
specifically with the cytoplasmic domain of beta PP and does not interact
with the beta-amyloid region. The protein encoded by this partial mouse
cDNA is identical to the C-terminus of the rat Fe65 protein. This mouse
protein also interacts with the homologous C-terminal domains of the mouse
amyloid precursor-like proteins, APLP1 and APLP2. These conserved
cytoplasmic regions contain a common amino acid motif, Asn-Pro-Thr-Tyr,
which has previously been shown to influence both the secretion and
internalization of beta PP. Fe65 has been implicated in regulatory and cell
signaling mechanisms because it contains two different motifs involved in
protein binding, a WW domain (a variant of Src homology 3 domains) and a
phosphotyrosine interaction domain (PID). Interestingly, the PID domain
binds to the same motif present in the conserved cytoplasmic domains of the
beta PP and beta PP-like proteins. RNA analyses reveal that Fe65 is
predominantly expressed in brain and in the regions most affected by
Alzheimer's disease (AD)-associated neuropathology. The human Fe65 mRNA was
cloned from a fetal brain cDNA library. The message encodes a protein of
735 amino acids that is 95% identical to the rat Fe65 protein. The human
Fe65 gene was mapped on human metaphase chromosomes to band 11p15 using
fluorescence in situ hybridization.
相似文献
967.
Antonio?CP?de Oliveira Eduardo?Candelario-Jalil Julia?Langbein Lena?Wendeburg Harsharan?S?Bhatia Johannes?CM?Schlachetzki Knut?Biber Bernd?L?FiebichEmail author 《Journal of neuroinflammation》2012,9(1):2
Background
Microglia are considered a major target for modulating neuroinflammatory and neurodegenerative disease processes. Upon activation, microglia secrete inflammatory mediators that contribute to the resolution or to further enhancement of damage in the central nervous system (CNS). Therefore, it is important to study the intracellular pathways that are involved in the expression of the inflammatory mediators. Particularly, the role of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and glycogen synthase kinase-3 (GSK-3) pathways in activated microglia is unclear. Thus, in the present study we investigated the role of Akt and its downstream pathways, GSK-3 and mTOR, in lipopolysaccharide (LPS)-activated primary rat microglia by pharmacological inhibition of these pathways in regard to the expression of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1 (mPGES-1) and to the production of prostaglandin (PG) E2 and PGD2. 相似文献968.
Ponte JC Junqueira SB Veiga RV Barreto ML Pontes-de-Carvalho LC Alcântara-Neves NM 《BMC immunology》2011,12(1):34
Background
Two conditions are used as markers of atopy: the presence of circulating anti-allergen IgE antibodies and the presence of positive skin prick test (SPT) reactions to allergenic extracts. The correlation between these conditions is not absolute. This study aimed at investigating immunological parameters that may mediate this lack of correlation. Individuals whose sera contained anti-B. tropicalis extract IgE antibodies (α-Bt E IgE) were divided into two groups, according to the presence or absence of skin reactivity to B. tropicalis extract (Bt E). The following parameters were investigated: total IgE levels; α-Bt E IgE levels; an arbitrary α-Bt E IgE/total IgE ratio; the proportion of carbohydrate-reactive α-Bt E IgE; the proportion of α-Bt E IgE that reacted with Ascaris lumbricoides extract (Al E); the production of IL-10 by Bt E- and Al E-stimulated peripheral blood cells (PBMC).Results
Total IgE levels were similar in the two groups, but α-Bt E IgE was significantly higher in the SPT-positive group (SPT+). A large overlap of α-Bt E IgE levels was found in individuals of both groups, indicating that these levels alone cannot account for the differences in SPT outcome. Individuals of the two groups did not differ, statistically, in the proportion of α-Bt E IgE that reacted with carbohydrate and in the production of IL-10 by Bt E- and Al E-stimulated PBMC. Both groups had part of α-Bt E IgE activity absorbed out by Al E, indicating the existence of cross-reactive IgE antibodies. However, the α-Bt E IgE from the SPT-negative individuals (SPT-) was more absorbed with AlE than the α-Bt E IgE from the SPT+ individuals. This finding may be ascribed to avidity differences of the α-Bt E IgE that is present in the two groups of individuals, and could occur if at least part of the α-Bt E IgE from the SPT- individuals were elicited by A. lumbricoides infection.Conclusion
The present results suggest that a low ratio of specific IgE to total IgE levels (in a minority of individuals), and differences in α-Bt E IgE avidities (which would have high affinities for A. lumbricoides antigens in SPT- than in SPT+ individuals) may play a role in the down-modulation of type-I hypersensitivity reaction against aeroallergens described in helminth-infected individuals.969.
970.
Rhonda Griffiths AM RN CM B.Ed MSc Dr.PH Jan Horsfall RN BA MA PhD Margo Moore RN BA MPH Di Lane RN BA Veronica Kroon RN CN BA Rachel Langdon BAppSci BA 《International journal of nursing practice》2009,15(3):172-184
Individual and community health outcomes are strengthened by friendships and social support networks. Community interventions aimed at improving the social factors that influence the health of individuals and communities increasingly include strategies to develop resilience through building networks and social capital. The study reported here used a cross-sectional survey design, administered at two time points, to measure the effect of a community capacity-building programme implemented by Women's Health Nurses. Data described and where possible measured women's perceptions of their physical and mental well-being, friendships and support networks, community connectedness and participation, safety, and knowledge of and access to local community services. The follow-up survey also measured the impact of specific community development initiatives. Overall, findings of both surveys were consistent, with some notable exceptions. For example, at follow up there was a significant improvement in mental health indicators and fewer women believed their physical or emotional problems imposed a considerable burden on their daily activities. They also believed people from other cultures were more likely to be accepted by neighbours and reported increased involvement in community activities as a direct result of the Villawood Icebreakers Project. 相似文献