全文获取类型
收费全文 | 52693篇 |
免费 | 869篇 |
国内免费 | 366篇 |
专业分类
耳鼻咽喉 | 569篇 |
儿科学 | 2687篇 |
妇产科学 | 1551篇 |
基础医学 | 7431篇 |
口腔科学 | 440篇 |
临床医学 | 2831篇 |
内科学 | 7639篇 |
皮肤病学 | 1027篇 |
神经病学 | 3721篇 |
特种医学 | 4466篇 |
外科学 | 8972篇 |
综合类 | 839篇 |
一般理论 | 1篇 |
预防医学 | 4393篇 |
眼科学 | 974篇 |
药学 | 2866篇 |
1篇 | |
中国医学 | 681篇 |
肿瘤学 | 2839篇 |
出版年
2023年 | 13篇 |
2022年 | 21篇 |
2021年 | 10篇 |
2020年 | 13篇 |
2019年 | 9篇 |
2018年 | 3510篇 |
2017年 | 4029篇 |
2016年 | 2320篇 |
2015年 | 1180篇 |
2014年 | 924篇 |
2013年 | 701篇 |
2012年 | 3930篇 |
2011年 | 1632篇 |
2010年 | 255篇 |
2009年 | 246篇 |
2008年 | 345篇 |
2007年 | 325篇 |
2006年 | 496篇 |
2005年 | 9802篇 |
2004年 | 13679篇 |
2003年 | 8464篇 |
2002年 | 892篇 |
2001年 | 265篇 |
2000年 | 107篇 |
1999年 | 177篇 |
1998年 | 102篇 |
1997年 | 28篇 |
1996年 | 63篇 |
1995年 | 35篇 |
1994年 | 29篇 |
1993年 | 34篇 |
1992年 | 28篇 |
1991年 | 22篇 |
1990年 | 24篇 |
1989年 | 12篇 |
1988年 | 14篇 |
1987年 | 18篇 |
1986年 | 19篇 |
1985年 | 15篇 |
1983年 | 10篇 |
1981年 | 6篇 |
1980年 | 7篇 |
1978年 | 8篇 |
1974年 | 5篇 |
1970年 | 5篇 |
1966年 | 7篇 |
1965年 | 5篇 |
1939年 | 5篇 |
1935年 | 6篇 |
1885年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Sang?Yeob?Lee Yong?Min?Jo Won?Tae?Chung Sung?Hyun?Kim Seung?Young?Kim Mee?Sook?Roh Sung?Won?LeeEmail author 《Rheumatology international》2012,32(4):1065-1068
Kaposi sarcoma (KS) is a vascular neoplasm mainly affecting the skin of the limbs that has previously been associated with
rheumatoid arthritis (RA). When compared with the RA patients treated with corticosteroids and immunosuppressive drugs, the
reported number of KS in RA patients was very rare. Although the exact mechanisms of developing KS in RA patients are unclear,
some drugs which include corticosteroid have been suggested as an etiological factor in previous case reports of RA and KS.
We report, here in, another case of KS associated with the initiation of leflunomide in a patient with RA. 相似文献
992.
Ligia?Brzezińska-Wcis?o Beata?Bergler-CzopEmail author Anna?Lis-?wi?ty 《Rheumatology international》2012,32(2):473-477
Sonozaki syndrome—pustulotic arthro-osteitis (PAO) is a relatively rare, chronic illness. This disease belongs to the group
of psoriatic arthritis (psoriasis arthropatica, artropatia psoriatica) which in turn belongs to the group of seronegative
arthritis. Sonozaki syndrome includes palmoplantar pustulosis, PPP as well as arthro-osteitis. Clinically, symmetrically localised
pustulae are observed on feet and hands. Effected joints are painful, swollen with a visible inflammation. Here, we describe
a case of a woman aged 55 with a diagnosis of Sonozaki syndrome and hyperthyroidism. At the moment of admission multiple changes
in the form of pustulae were observed on hands and soles, filled with pus and blood of the erythemal basis. Oral and genital
mucosa were free from changes. The oedema within clavicle and sternum joints was without features of the severe inflammation
and tactical tenderness. In additional tests, increased BSR 36/62 was found. Bone scintigraphy—focuses of increased accumulation
of MDP-Tc-99 m were found in the sternal projection of the clavicle ends at both sides, and the left-side change is bigger
and more strongly saturated and can probably progress to the sternum’s manubrium. As a result of the used treatment during
hospitalisation, (cyclosporine 3 mg/kg and steroid external therapy upon the skin changes) the improvement of the local changes
was observed as well as no progression in the joints’ changes. At the moment, the patient is treated in the dermatological
and rheumatological out-clinic. Early and correct diagnostics allows for efficient treatment of Sonozaki syndrome and decreases
the risk of potential complications, such as the described systemic amyloidosis. 相似文献
993.
Kerna I Kisand K Laitinen P Tamm AE Kumm J Lintrop M Tamm AO 《Rheumatology international》2012,32(2):519-523
ADAM12 (A disintegrin and metalloprotease) is one of the candidate genes demonstrating susceptibility to osteoarthritis. The purpose
of this study was to investigate the relationship between ADAM12-S protein and radiographic knee osteoarthritis (KOA) and
its correlation to several bone and cartilage biomarkers. The ADAM12-S protein was measured in 276 subjects (60% women, aged
32–60 years), including 181 individuals with and 95 without radiographic KOA features. The radiographs were obtained from
both tibiofemoral (TF) and patellofemoral (PF) joints. The serum levels of ADAM12-S protein were measured by DELFIA1/AutoDELFIA
research kit. The ADAM12-S protein was found in detectable ranges in 43 subjects (16 men), without statistical difference
between the two genders. In the whole group, the ADAM12-S was related to radiographic KOA grades in TF (P = 0.004) as well in PF joint (P = 0.003). We also found a correlation between ADAM12-S protein and osteophytes in TF and/or PF joints (P = 0.003). No correlations were found between serum levels of S-CTx-I (C-terminal cross-linked telopeptides of type I collagen)
or S-PINP (type I procollagen N-terminal propeptide) and ADAM12-S. Similarly, in the whole group, the ADAM12-S protein was
not correlated with U-CTx-II (urinary C-telopeptide fragments of type II collagen); however, in the female group, trend to
positive correlation between the investigated biomarkers (P = 0.019) was observed. The ADAM12-S protein could be elevated in some KOA cases, and this elevation correlates with the grades
of the disease, mostly owning to development of osteophytes. This finding suggests the possible involvement of the ADAM12-S
protein in the pathogenesis of KOA. 相似文献
994.
Sjogren’s syndrome (SS) is a systemic autoimmune disease characterized by xerophthalmia, xerostomia and extraglandular manifestations.
Anemia, leukopenia, thrombocytopenia and lymphoproliferative disorders, including lymphoma are well-known extraglandular,
hematological complications of SS. We report here a rare case of patient with primary SS who developed pancytopenia with severe
thrombocytopenia as an initial manifestation and successfully treated with IV immunoglobulin (IVIG). The present case suggests
that pancytopenia with severe thrombocytopenia can be a difficult-to-treat abnormality, and initial manifestation of primary
SS and IVIG might be an effective treatment for severe thrombocytopenia refractory to high-dose steroid in primary SS. 相似文献
995.
Koebner phenomenon is defined as a nonspecific skin stimulus eliciting a disease skin reaction. The nature of the skin trauma
varies greatly and includes areas of thermal injury, excoriations, surgical incisions, and scars. We report a patient with
recent onset of systemic lupus erythematosus who developed Herpes zoster on immunosuppressant medication. Two weeks after
resolution of the vesicles, the patient presented with new ulcerative reddish lesions over the herpes zoster scare and worsening
of her malar rash without evidence of worsening of any other organ. Koebner phenomenon was suspected. We review the literature
on Koebner phenomenon in SLE. 相似文献
996.
Sarcoidosis is a chronic, multisystemic, non-caseating granulomatous disease of unknown etiology. Nasopharyngeal involvement
is very rare in sarcoidosis. The objective of this report was to evaluate a rare involvement of sarcoidosis. This report includes
a case of nasopharyngeal sarcoidosis. A 51-year-old female with nasopharyngeal sarcoidosis was treated as sarcoidosis, and
she was better. Nasopharyngeal involvement is very rare in sarcoidosis but it must be kept in mind. 相似文献
997.
Eight patients with refractory lupus nephritis received rituximab after failing standard sequential therapy and were followed
for 104 weeks after the infusion. One patient died secondary to a complicated pregnancy but had stable renal function. Three
patients received a re-infusion of rituximab approximately 12 months apart due to a renal flare; during the second year of
follow-up, those patients progressed toward ESRD. The four remaining patients demonstrated improvements in SLEDAI score, CrCl,
and proteinuria with maintenance of their standard immunosuppressive therapy and did not require a re-infusion of rituximab.
Although rituximab as induction therapy for refractory lupus nephritis has been shown to have a good response, its efficacy
in long-term assessments demonstrates disappointing results. 相似文献
998.
The hydroxy-methyl-glutaryl-CoA reductase inhibitors (statins) are used extensively in the treatment for hyperlipidemia. They
have also demonstrated a benefit in a variety of other disease processes, including a wide range of rheumatologic disorders.
These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropic
effects of statins in rheumatologic disorders and emphasizes the importance of randomized, placebo-controlled trials to further
elucidate this interesting phenomenon. 相似文献
999.
Alkaptonuria is a rare autosomal recessive metabolic disorder characterized by a deficiency of homogentisate 1,2-dioxygenase
(HGO) in the liver. This results in excretion of large quantities of homogentisic acid (HGA) (also called alkapton) in the
urine and a slowly progressive deposition of homogentisic acid and its oxidative product in connective tissues. Clinical characteristic
features of alkaptonuria are darkening of urine, bluish-dark pigmentation of connective tissues (ochronosis) and arthritis
of large joints and spine. Cardiovascular and genitourinary systems may also be affected. In this report, we present the initial
results of screening family members with history of alkaptonuria in southern region of Jordan. We present 9 cases of alkaptonuria
(two males and seven females) in one Jordanian family. The history, signs and symptoms, diagnostic techniques and treatment
options of alkaptonuria are reviewed in this article. 相似文献
1000.
The aim of this study was to explore whether the candidate gene polymorphisms contribute to fibromyalgia susceptibility. The
authors conducted a meta-analysis on associations between serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR)
S/L allele, catechol-O-methltransferase (COMT) val158Met, and serotonin 2A (5-HT2A) receptor 102T/C polymorphisms and fibromyalgia
susceptibility as determined using the following: (1) allele contrast, (2) recessive, (3) dominant models, and (4) contrast
of homozygotes. We also performed a systematic review with available data of the candidate genes. A total of 21 separate comparisons
were considered in this systematic review and meta-analysis. Seventeen candidate genes and over 35 different polymorphisms
were identified in studies on fibromyalgia susceptibility. Meta-analysis of the 5-HTTLPR S/L allele and COMT val158Met failed
to reveal any association with fibromyalgia. However, meta-analysis of the C allele, CC + CT genotype, and CC versus TT genotype
of the 5-HT2A receptor 102T/C polymorphism showed significant association with fibromyalgia. The overall OR of the association
between the C allele and fibromyalgia was 1.333 (95% CI = 1.053–1.688, P = 0.017). The ORs for the CC + CT genotype, and CC versus TT genotype showed the same pattern as that observed for the C
allele (OR = 1.541, 95% CI = 1.032–2.303, P = 0.035; OR = 1.838, 95% CI = 1.151–2.936, P = 0.011). This meta-analysis demonstrates that the 5-HT2A receptor 102T/C polymorphism confers susceptibility to fibromyalgia.
In contrast, no association was found between the 5-HTTLPR S/L allele, COMT val158Met, and susceptibility to fibromyalgia. 相似文献