全文获取类型
收费全文 | 886篇 |
免费 | 53篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 39篇 |
妇产科学 | 9篇 |
基础医学 | 99篇 |
口腔科学 | 44篇 |
临床医学 | 80篇 |
内科学 | 195篇 |
皮肤病学 | 40篇 |
神经病学 | 28篇 |
特种医学 | 154篇 |
外国民族医学 | 1篇 |
外科学 | 72篇 |
综合类 | 43篇 |
预防医学 | 56篇 |
眼科学 | 5篇 |
药学 | 52篇 |
中国医学 | 1篇 |
肿瘤学 | 27篇 |
出版年
2022年 | 2篇 |
2021年 | 3篇 |
2020年 | 4篇 |
2019年 | 11篇 |
2018年 | 16篇 |
2017年 | 19篇 |
2016年 | 15篇 |
2015年 | 25篇 |
2014年 | 14篇 |
2013年 | 32篇 |
2012年 | 25篇 |
2011年 | 27篇 |
2010年 | 36篇 |
2009年 | 45篇 |
2008年 | 27篇 |
2007年 | 24篇 |
2006年 | 15篇 |
2005年 | 15篇 |
2004年 | 32篇 |
2003年 | 16篇 |
2002年 | 8篇 |
2001年 | 7篇 |
2000年 | 6篇 |
1999年 | 18篇 |
1998年 | 54篇 |
1997年 | 62篇 |
1996年 | 56篇 |
1995年 | 43篇 |
1994年 | 40篇 |
1993年 | 37篇 |
1992年 | 7篇 |
1991年 | 12篇 |
1990年 | 16篇 |
1989年 | 15篇 |
1988年 | 24篇 |
1987年 | 24篇 |
1986年 | 25篇 |
1985年 | 12篇 |
1984年 | 4篇 |
1983年 | 8篇 |
1982年 | 18篇 |
1981年 | 3篇 |
1980年 | 9篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1976年 | 6篇 |
1975年 | 2篇 |
1968年 | 3篇 |
1959年 | 2篇 |
排序方式: 共有950条查询结果,搜索用时 15 毫秒
101.
102.
Satish Misra Peter van Dam Jonathan Chrispin Fabrizio Assis Ali Keramati Aravindan Kolandaivelu Ronald Berger Harikrishna Tandri 《Journal of electrocardiology》2018,51(5):801-808
Background
View into Ventricular Onset (VIVO) is a novel ECGI system that uses 3D body surface imaging, myocardial CT/MRI, and 12?lead ECG to localize earliest ventricular activation through analysis of simulated and clinical vector cardiograms.Objective
To evaluate the accuracy of VIVO for the localization of ventricular arrhythmias (VA).Methods
In twenty patients presenting for catheter ablation of VT [8] or PVC [12], VIVO was used to predict the site earliest activation using 12?lead ECG of the VA. Results were compared to invasive electroanatomic mapping (EAM).Results
A total of 22 PVC/VT morphologies were analyzed using VIVO. VIVO accurately predicted the location of the VA in 11/13 PVC cases and 8/9 VT cases. VIVO correctly predicted right vs left ventricular foci in 20/22 cases.Conclusion
View into Ventricular Onset (VIVO) can accurately predict earliest activation of VA, which could aid in catheter ablation, and should be studied further. 相似文献103.
104.
Mahmud E Keramati S Salami A Palakodeti V Tsimikas S 《The Journal of invasive cardiology》2005,17(4):207-210
Percutaneous rotational atherectomy is mainly utilized in contemporary interventional practice to alter lesion compliance, facilitating stent delivery and antirestenotic drug delivery at the site of the underlying lesion. This enables a percutaneous revascularization strategy in a group of patients who would otherwise require a surgical revascularization. We identify and present three novel uses for this device in percutaneous coronary and peripheral interventional procedures, which further expands the applications of rotational atherectomy. 相似文献
105.
106.
Adhesion of sickle neutrophils and erythrocytes to fibronectin 总被引:2,自引:0,他引:2
The pathophysiology of vaso-occlusive crisis in sickle cell disease involves interactions among blood cells, plasma proteins, and vessel wall components. The initial goal of this work was to quantify the adhesion of sickle red blood cells (RBCs) to fibronectin immobilized on glass under both static and dynamic shear stress conditions. High-power microscopic inspection of static assay plates showed striking numbers of adherent neutrophils as well as RBCs. Sickle neutrophils and RBCs were significantly more adherent to fibronectin than the corresponding normal cells in static adhesion assays. Adhesion of both sickle neutrophils and sickle RBCs in dynamic adhesion assays was promoted by a period of static incubation preceding initiation of shear stress conditions. Adherent neutrophils remained attached at shear stresses up to 51 dyne/cm2; most adherent RBCs were attached at shear stresses up to 13 dyne/cm2, but detached at a shear stress of 20 dyne/cm2. Sickle neutrophil adhesion was enhanced significantly by autologous plasma. Elevated levels of plasma interleukin-6 (IL-6; but not IL-1 or IL-8) were found in 6 of 9 sickle cell disease samples examined, and elevated levels of tumor necrosis factor were found in 2 of 9 samples. Plasma IL- 6 levels correlated positively with both the number of sickle neutrophils adherent to fibronectin and the ability of sickle plasma to enhance adhesion of normal neutrophils to fibronectin. These data suggest possible roles for neutrophil activation and for fibronectin in mediating sickle neutrophil and RBC adhesion. 相似文献
107.
Bone marrow transplantation for patients with Philadelphia chromosome- positive acute lymphoblastic leukemia 总被引:1,自引:2,他引:1
Forman SJ; O'Donnell MR; Nademanee AP; Snyder DS; Bierman PJ; Schmidt GM; Fahey JL; Stein AS; Parker PM; Blume KG 《Blood》1987,70(2):587-588
We report the treatment outcome of allogeneic bone marrow transplantation in ten patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Six patients are alive and well for 6 to 30 months (median 19 months) after transplantation. Four patients died with transplant related complications. In view of the poor prognosis associated with this disease, marrow ablation followed by allogeneic or syngeneic marrow grafting may be the preferred treatment modality if a suitable marrow donor is available. 相似文献
108.
109.
The presence of BCR-ABL fusion genes has important diagnostic and prognostic implications in chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). The CML-specific chimeric BCR-ABL gene with a break involving the major breakpoint cluster region (M-bcr) of the BCR-gene has been detected by means of fluorescence in situ hybridization (FISH). In this study, we present a FISH protocol that allows the detection of breaks in both the major and the minor breakpoint cluster region (m-bcr). Three hybridization signals of D107F9, a yeast artificial chromosome (YAC)-derived probe spanning the breakpoint regions of the BCR gene, were indicative of the translocation events. To increase the specificity further, this probe was combined with cos-abl 8, a cosmid probe flanking the breakpoint within the ABL gene for dual-color hybridization. Samples of 21 patients with CML, the ALL-derived cell line SUP-B15, and of seven patients with Philadelphia chromosome (Ph1)-positive ALL (three of them with breakpoints within m-bcr) were examined. BCR-ABL fusion was detected in all cases with high specificity (false-positive nuclei: mean, 0.1%). On cytogenetic preparations, the percentages of BCR-ABL- positive interphase cells ranged from 53% to 91%. Comparable efficiencies were achieved on blood smears. In conclusion, hybridization with D107F9 and cos-abl 8 allows unambiguous diagnosis of BCR-ABL genes and is likely to become an important tool for the monitoring of therapies in patients with CML and ALL. 相似文献
110.
Snyder DS; Negrin RS; O'Donnell MR; Chao NJ; Amylon MD; Long GD; Nademanee AP; Stein AS; Parker PM; Smith EP 《Blood》1994,84(5):1672-1679
Ninety-four consecutive patients with chronic myelogenous leukemia in first clinical chronic phase, median age of 34.0 years (range, 6.8 to 52.4 years), with a histocompatible sibling donor, were treated with fractionated total body irradiation (1,320 cGy) and high-dose etoposide (60 mg/kg) followed by allogeneic bone marrow transplantation (BMT). The median time from diagnosis to BMT was 7.0 months (range, 2.3 to 72.0 months). Sixty patients were treated before BMT with hydroxyurea alone, four patients with busulfan alone, one patient with interferon alone, and the other 29 patients were treated with various combinations of these drugs. Cumulative probabilities of overall survival, event- free survival, and relapse at 5 years were 73%, 64%, and 14%, respectively. The median follow-up time for surviving patients was 38 months, ranging from 12 to 88 months. By stepwise Cox regression analysis, significant prognostic variables were age at transplant, acute graft-versus-host disease > or = grade II, cytomegalovirus- associated interstitial pneumonitis, and years from diagnosis to BMT. 相似文献