全文获取类型
收费全文 | 21172篇 |
免费 | 985篇 |
国内免费 | 155篇 |
专业分类
耳鼻咽喉 | 212篇 |
儿科学 | 429篇 |
妇产科学 | 222篇 |
基础医学 | 2800篇 |
口腔科学 | 462篇 |
临床医学 | 1362篇 |
内科学 | 5468篇 |
皮肤病学 | 394篇 |
神经病学 | 2023篇 |
特种医学 | 857篇 |
外科学 | 3403篇 |
综合类 | 106篇 |
预防医学 | 591篇 |
眼科学 | 421篇 |
药学 | 1312篇 |
中国医学 | 48篇 |
肿瘤学 | 2202篇 |
出版年
2023年 | 133篇 |
2022年 | 243篇 |
2021年 | 452篇 |
2020年 | 238篇 |
2019年 | 366篇 |
2018年 | 464篇 |
2017年 | 388篇 |
2016年 | 498篇 |
2015年 | 501篇 |
2014年 | 629篇 |
2013年 | 789篇 |
2012年 | 1280篇 |
2011年 | 1445篇 |
2010年 | 766篇 |
2009年 | 656篇 |
2008年 | 1237篇 |
2007年 | 1428篇 |
2006年 | 1327篇 |
2005年 | 1439篇 |
2004年 | 1432篇 |
2003年 | 1387篇 |
2002年 | 1287篇 |
2001年 | 301篇 |
2000年 | 280篇 |
1999年 | 338篇 |
1998年 | 311篇 |
1997年 | 241篇 |
1996年 | 215篇 |
1995年 | 220篇 |
1994年 | 158篇 |
1993年 | 147篇 |
1992年 | 169篇 |
1991年 | 154篇 |
1990年 | 127篇 |
1989年 | 156篇 |
1988年 | 137篇 |
1987年 | 118篇 |
1986年 | 106篇 |
1985年 | 96篇 |
1984年 | 87篇 |
1983年 | 59篇 |
1982年 | 49篇 |
1981年 | 45篇 |
1980年 | 47篇 |
1979年 | 59篇 |
1978年 | 39篇 |
1976年 | 27篇 |
1975年 | 30篇 |
1974年 | 28篇 |
1973年 | 24篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Tetsuhiko Nagao Seizo Sadoshima Takao Ishitsuka Kenji Kusuda Osamu Shiokawa Setsuro Lbayashi Masatoshi Fujishima 《Clinical and experimental pharmacology & physiology》1992,19(7):489-493
1. The effects of acute bilateral superior cervical ganglionectomy on cerebral blood flow and metabolism were investigated in stroke-prone spontaneously hypertensive rats (SHRsp), before and during cerebral ischaemia. 2. The resting cerebral blood flow was comparable between the control and denervated animals. 3. There was no significant difference in cerebral blood flow or concentration of tissue energy metabolites (adenosine triphosphate [ATP], lactate and pyruvate) between the sham-operated control and denervated animals during ischaemia. 4. The results suggest that sympathetic innervation of cerebral vessels originating from superior cervical ganglia may not play a major role in the progression of cerebral ischaemia in SHRsp. 相似文献
32.
33.
Makoto Kamada Kenji Ohsaka Susumu Nagamine Hidemitsu Kakihata 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2003,51(10):552-556
Acute aortic dissection complicated with acute myocardial infarction (AMI) is the most fatal situation. We experienced the
successful treatment for acute type A aortic dissection complicated with inferior AMI following aortic valve replacement (AVR).
A 60-year-old man had had AVR for aortic regurgitation. Sixteen months after the AVR, he had a sudden onset of severe chest
pain with complete atrioventricular block. Immediately, temporary pacing and cardiac catheterization were conducted, showing
the occlusion of the right coronary artery due to acute type A aortic dissection. On his way to our hospital, direct current
shock was conducted 3 times for ventricular fibrillation. We replaced the ascending aorta combined with coronary artery bypass
grafting and the postoperative course was uneventful. The key to treat acute aortic dissection complicated with AMI is early
accurate diagnosis, prompt temporary pacing for bradycardia, defibrillation for lethal arrhythmia and insertion of a perfusion
catheter if possible. These preoperative hemodynamic stabilization gives us the chance to save these patients. 相似文献
34.
Yusuke Kishikawa Daiki Masaki Yurinosuke Kitabayashi Naosuke Tani Akira Hirogane Kenji Fukui 《Nihon Arukōru Yakubutsu Igakkai zasshi》2003,38(5):434-439
In order to find useful information for the establishment of new treatment method to alcohol dependence, we investigated the change of the body image of patients with alcohol dependence before and after the treatment. HABIT (Haga Body Image Test), a questionnaire about body image developed in department of psychiatry in Kyoto Prefectural University of Medicine, was used to examine the change of body image between pre- and post-3-month conventional treatment program in 46 patients with alcohol dependence hospitalized into special institutions for treatment of the disease in Kyoto. Patients with poor outcome of the treatment showed improvement of body image on visceral function, feeling of appetite and outward appearance, while patients with good outcome indicated no significant change in these aspects. This finding likely suggests that the treatment would result in good outcome in patients having stable feeling of physical health, and the cognitive treatment approach about these aspects of body image should be performed on the patients with poor treatment outcome. On the other hand, the body image about motor function showed significantly higher score in the patients approach for the patients with poor outcome to become aware of their physical activity would be effective. 相似文献
35.
Aortic arch replacement with proximal first technique. 总被引:2,自引:0,他引:2
Yuji Miyamoto Kenji Onishi Masataka Mitsuno Koichi Toda Masao Yoshitatsu Kazuo Abe 《Annals of thoracic and cardiovascular surgery》2003,9(6):389-393
BACKGROUND: Deep hypothermic circulatory arrest (DHCA) without retrograde cerebral perfusion (RCP) has a strict time limit. We modified a surgical technique for anastomosis to shorten the period of DHCA and unilateral cerebral perfusion (UCP). METHODS: Between March 1993 and August 2001, retrospective analysis was done on 23 consecutive patients, who underwent aortic arch replacement with branches. The patients were divided into two groups: DHCA group and UCP group. The DHCA group, in which DHCA alone and without additional cerebral perfusion was performed, comprised of nine patients. Proximal aortic anastomosis was performed first during systemic cooling; then both the brachiocephalic artery and left carotid artery were reconstructed with the branches of the artificial graft during circulatory arrest; thereafter, cerebral and coronary perfusions were resumed. The UCP group, in which DHCA was not used but right hemisphere perfusion during deep hypothermia was performed when the origin of brachiocephalic artery was safely clamped, consisted of 14 patients. RESULTS: Mean time of DHCA was 18.8+/-4.2 minutes and that of right hemisphere perfusion time was 11.0+/-3.8 minutes, respectively. Twenty-one patients survived the surgery (91.3%), and two (8.7%) died during hospitalization. Transient cerebral complication occurred in four patients in the DHCA group and all recovered. Logistic regression analysis revealed that DHCA was the only parameter to significantly influence temporary neurological dysfunction. There was no other significant difference between the two groups. CONCLUSION: With our modified and simple surgical technique for aortic arch repair, we were able to successfully shorten the DHCA time and right hemisphere perfusion time. However, because DHCA was the only parameter to significantly influence temporary neurological dysfunction, some form of continuous cerebral perfusion at deep hypothermia may be a safer method to preserve cerebral function. 相似文献
36.
Masahito Minakawa Kenji Takahashi Norihiro Kondo Masaharu Hatakeyama Toshihiko Kuga Ikuo Fukuda 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2003,51(11):582-587
Objective: Reoperative coronary bypass grafting is at high risk. Particularly in redo cases where the patent graft is running near
the midline of the sternum, the graft may be exposed to injury by a median sternotomy and subsequent dissection. Whereas,
off-pump bypass grafting from the left axillary artery or descending thoracic artery by a left thoracotomy approach is safe
for preventing graft damage.Methods: From March 1998 to February 2002, we performed off-pump coronary artery bypass grafting by a left thoracotomy approach in
9 patients. The left axillary artery was used as the inflow vessel in 4 cases, and the descending thoracic, aorta in 5.Results: The radial artery was anastomosed proximally to the axillary artery in 4 cases and the descending thoracic aorta in one
case. The saphenous vein graft was anastomosed, proximally to the descending thoracic aorta in 4 cases. Transdiaphragmatic
minimally invasive bypass grafting for the right coronary artery was simultaneously performed in 3 cases. Postoperative cardiac
events were ventricular arrhythmia in 6 cases and supraventricular arrhythmia in 3 cases. There was no damage to the patent
grafts. Postoperative coronary angiography performed, in 8 cases revealed all the grafts to be patent without stenosis. Cardiac
symptoms were not found after the operation in any of the cases.Conclusions: These procedures can prevent the injury to patent grafts caused by a median sternotomy, and will be one of the useful strategies
for reoperative off-pump coronary artery bypass grafting. 相似文献
37.
Kenji Yoshimi Masatoshi Takeda Tsuyoshi Nishimura Takashi Kudo Yu Nakamura Kunitoshi Tada Nobuyoshi Iwata 《Brain research》1991,560(1-2):149-158
Changes in MAP2 and clathrin immunoreactivity were studied in gerbil hippocampus after transient cerebral ischemia. MAP2 immuno-reactivity decreased significantly by 1 h in the subiculum-CA1 and CA2 areas which correspond to reactive change, while no decrease was observed in CA1 until day 4. Before the initiation of delayed neuronal death, MAP2 immunoreactivity was not changed in CA1. On the other hand clathrin immunoreactivity increased in the pyramidal cell layer of CA1 by 3 h after ischemia and remained high for 2 days. Clathrin immunoreactivity in the pyramidal cell layer of CA1 diminished after delayed neuronal death. The transient change of clathrin was noted especially in CA1 in the period prior to delayed neuronal death. These results imply an abnormal change in clathrin turnover after ischemia, which may participate in the pathogenesis of delayed neuronal death. 相似文献
38.
Hideyuki Iwai Ryuji Koike Jun Ogawa Takahiko Sugihara Hiroyuki Hagiyama Kenji Nagasaka Yoshinori Nonomura Junko Nishio Toshihiro Nanki Rieko Tsubata Hitoshi Kohsaka Tetsuo Kubota Nobuyuki Miyasaka 《Nihon Rinshō Men'eki Gakkai kaishi》2002,25(3):270-276
A 36-year-old man was admitted to a hospital with complaints of fever, polyarthralgia and dyspnea. Erythema was observed on his face, extensor surface of the fingers and extremities, and a chest X-ray revealed massive bilateral pleural effusion. He had no sign of myopathy at this point. Pleural fluid was proved to be exudative and contained extremely high levels of hyaluronic acid. He was also complicated with interstitial pneumonitis and was given a pulse therapy with methyl prednisolone followed by daily administration of 55 mg prednisolone (PSL). Twenty days after the commencement of the therapy, pleural effusion decreased but muscle weakness gradually appeared, accompanied by elevation of myogenic enzymes. Myogenic changes on electromyogram, and irregularity of the muscle fibers with slight inflammatory cell infiltrates in a biopsy specimen were demonstrated. He was transferred to our hospital, and a diagnosis of dermatomyositis was made. Later, pleural effusion waxed and waned depending on the dosage of PSL, but no other causative disorder was demonstrated by extensive examinations. This case indicates that the pleuritis could be one of the vasculitic manifestations of dermatomyositis. 相似文献
39.
Haruo Nagayama Kounosuke Tsuchiyama Kenji Yamada Jotaro Akiyoshi 《Progress in neuro-psychopharmacology & biological psychiatry》1991,15(6):735-744
1. In our series of experiments the role of serotonin in human depression was studied by using animal models of depression.
2. The results of these studies support the hypothesis that some types of human depression may be primarily due to an excessive transmission of serotonin at the synapse. 相似文献
40.
Genetic alteration in carcinoid tumors of the lung. 总被引:1,自引:0,他引:1
Kenji Sugio Toshihiro Osaki Tsunehiro Oyama Mitsuhiro Takenoyama Takeshi Hanagiri Masaru Morita Koji Yamazaki Akira Nagashima Hisashi Nakahashi Yoshihiko Maehara Kosei Yasumoto 《Annals of thoracic and cardiovascular surgery》2003,9(3):149-154
Surgically resected specimens of 13 carcinoid tumors of the lung including nine typical carcinoids and four atypical carcinoids, and eight salivary gland type carcinomas (six mucoepidermoid carcinomas and two adenoid cystic carcinomas) were analyzed regarding p53 expression, loss of heterozygosity (LOH) in chromosome 3p, 9p, and K-ras mutation. The overexpression of p53 was identified in four atypical carcinoid tumors, one mucoepidermoid carcinoma, and one adenoid cystic carcinoma, however, none of typical carcinoids showed p53 immunoreactivity. LOH in 3p14 was demonstrated in three of seven informative cases in all tumors. LOH in 9p was demonstrated in two of five informative cases in all tumors. Two of three cases with LOH at 3p14 had a poor prognosis, one of which also had LOH at 9p. No mutation of the K-ras gene was observed in any of these tumors. These data thus indicate that p53 overexpression might distinguish atypical carcinoid tumors from typical tumors and might therefore be useful as an adjunct modality in the differential diagnosis of pulmonary carcinoid tumors. The presence of LOH at 3p14 or 9p may thus help to identify lung cancer patients with a poor prognosis. 相似文献