全文获取类型
收费全文 | 2045篇 |
免费 | 96篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 13篇 |
妇产科学 | 17篇 |
基础医学 | 182篇 |
口腔科学 | 51篇 |
临床医学 | 124篇 |
内科学 | 705篇 |
皮肤病学 | 20篇 |
神经病学 | 68篇 |
特种医学 | 113篇 |
外科学 | 332篇 |
综合类 | 13篇 |
预防医学 | 63篇 |
眼科学 | 8篇 |
药学 | 104篇 |
中国医学 | 6篇 |
肿瘤学 | 323篇 |
出版年
2023年 | 7篇 |
2022年 | 29篇 |
2021年 | 39篇 |
2020年 | 22篇 |
2019年 | 33篇 |
2018年 | 47篇 |
2017年 | 45篇 |
2016年 | 52篇 |
2015年 | 51篇 |
2014年 | 49篇 |
2013年 | 77篇 |
2012年 | 121篇 |
2011年 | 163篇 |
2010年 | 93篇 |
2009年 | 58篇 |
2008年 | 105篇 |
2007年 | 109篇 |
2006年 | 126篇 |
2005年 | 94篇 |
2004年 | 90篇 |
2003年 | 108篇 |
2002年 | 108篇 |
2001年 | 54篇 |
2000年 | 50篇 |
1999年 | 51篇 |
1998年 | 23篇 |
1997年 | 29篇 |
1996年 | 11篇 |
1995年 | 17篇 |
1994年 | 13篇 |
1993年 | 20篇 |
1992年 | 35篇 |
1991年 | 28篇 |
1990年 | 28篇 |
1989年 | 22篇 |
1988年 | 16篇 |
1987年 | 19篇 |
1986年 | 15篇 |
1985年 | 16篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1982年 | 6篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1979年 | 8篇 |
1978年 | 13篇 |
1974年 | 7篇 |
1969年 | 5篇 |
1968年 | 3篇 |
1967年 | 5篇 |
排序方式: 共有2158条查询结果,搜索用时 15 毫秒
51.
52.
53.
54.
55.
56.
Background and objective: Rapidly progressive interstitial pneumonia (RPIP), including acute exacerbations of interstitial pneumonia, is associated with high rates of mortality. The present study was performed to examine the effects of respiratory management using non‐invasive ventilation (NIV) in patients with RPIP and to assess the prognostic factors for survival. Methods: BiPAP Vision was used for NIV. Clinical data and information on NIV were retrospectively obtained from patient records. Survival at 30 days was evaluated, and biomarkers were measured after initiation of NIV. Results: Thirty‐eight patients who had been admitted with RPIP and treated by NIV were included in the study. The ratio of PaO2 to fraction of inspired oxygen at initiation of NIV was higher in survivors than in non‐survivors (P = 0.0054). The mean duration to initiation of NIV after admission was significantly shorter in survivors than in non‐survivors (P = 0.0006). Serum Krebs von den Lungen‐6 (KL‐6) and LDH levels at the start of NIV were higher in non‐survivors than in survivors (KL‐6, P = 0.022; LDH, P = 0.044). Bivariate logistic regression analysis showed that early intervention with NIV was a significant predictor of survival at 30 days. In addition, the ratio of PaO2 to fraction of inspired oxygen and both LDH and KL‐6 levels at initiation of NIV were significant predictors of survival. Conclusions: Early intervention with NIV, mainly continuous positive pressure ventilation, is beneficial for the management of patients with RPIP. A randomized controlled study in a large population is needed to confirm the value of early NIV. 相似文献
57.
Ikuta T Kanno K Arihiro K Matsuda S Kishikawa N Fujita K Tazuma S 《Hepatology research》2012,42(3):310-320
Aim: Patients with non‐alcoholic steatohepatitis (NASH) frequently have many co‐morbidities including essential hypertension, which is reported to increase vascular production of reactive oxygen species (ROS) and alter the hepatic anti‐oxidant defense system. Since ROS play a role in the pathogenesis of NASH, it is hypothesized that hypertension modulates the hepatic oxidative status and influences the development of NASH. The aim of this study was to investigate the potential effects of hypertension on the progression of NASH. Methods: Spontaneously hypertensive rats (SHR) and Wistar‐Kyoto (WKY) rats as normotensive controls were fed choline‐deficient (CD) diet for 5 weeks. Histological changes, messenger RNA (mRNA) expression and thiobarbituric acid reactive substances (TBARS) levels in the liver were assessed in each group. Results: Choline‐deficient diet led to pronounced hepatic steatosis in SHR with an 8‐fold increase of the hepatic triglyceride content, while there was no significant increase in WKY. These changes in SHR were associated with significant reduction in the expression of mRNA for peroxisome proliferator activated receptor α, acyl‐CoA oxidase, microsomal triglyceride transfer protein, and apolipoprotein B100. Consistent with the significant reduction of hepatic superoxide dismutase activity and marked downregulation of the gene expression of hepatic antioxidant enzymes, the hepatic TBARS level and the plasma level of alanine aminotransferase were only increased in SHR on CD diet. Conclusions: Spontaneously hypertensive rats receiving CD diet showed severe hepatic steatosis associated with reduction of hepatic anti‐oxidant capacity, leading to increased hepatic oxidative stress and tissue damage. Accordingly, hypertension might have a potential effect on the progression of NASH. 相似文献
58.
Oyama K Tsujimoto A Otsuka E Shimizu Y Shiratsuchi K Tsubota K Takamizawa T Miyazaki M 《Dental materials journal》2012,31(1):26-31
We compared the surface free energies and enamel bond strengths of single-step self-etch adhesives with and without an oxygen-inhibited layer. The adhesives were applied to the enamel surfaces of bovine incisors, light irradiated, and the oxygen-inhibited layer was either retained or removed with ethanol. The surface free energies and their components (γ(S)(LW), γ(S)(+), and γ(S)(-)) were determined by measuring the contact angles of three test liquids placed on the cured adhesives. The enamel bond strengths of specimens with and without the oxygen-inhibited layer were measured. For all surfaces, the value of the estimated surface tension component γ(S)(LW) was relatively constant. The value of the γ(S)(+) component increased slightly when the oxygen-inhibited layer was removed, whereas that of the γ(S)(-) component decreased significantly. The enamel bond strengths of the self-etch adhesives were significantly lower in the specimens without an oxygen-inhibited layer. The oxygen-inhibited layer therefore appeared to promote higher enamel bond strength. 相似文献
59.
Kenji Ishido Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Tohru Sasaki Chikatoshi Katada Shouko Komori Kazushige Hayakawa Kei Hosoda Keishi Yamashita Natsuya Katada Wasaburo Koizumi 《Japanese journal of radiology》2016,34(1):35-42
Objectives
Whether chemoradiotherapy (CRT) is clinically beneficial for the management of postoperative recurrence of advanced gastric cancer remains unclear. We retrospectively studied treatment outcomes in patients who had unresectable localized recurrence after surgery for advanced gastric cancer and evaluated the safety and efficacy of CRT.Methods
The study group comprised 21 patients who received concurrent CRT for unresectable localized recurrence after undergoing R0 resection for stage II/III advanced gastric cancer. Localized recurrence was defined as a few or limited recurrent lesions.Results
The recurrence pattern was anastomotic recurrence in 7 patients, abdominal lymph-node recurrence in 12, and anastomotic recurrence plus abdominal lymph-node recurrence in 2. The median total dose of radiotherapy was 48.6 Gy (range 39.6–56.0), and the CRT completion rate was 100 % (21 of 21 patients). CRT-related grade 3 or higher toxicity comprised neutropenia in 33.3 % of patients and anorexia in 9.5 %. The response rate was 61.9 % (complete response 38.1 %, partial response 23.8 %). The median overall survival was 35.0 months.Conclusions
We conclude that CRT may become one treatment strategy for the management of unresectable localized recurrence after curative resection of advanced gastric cancer.60.
Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Nguyen T Chai J Li A Akahoshi T Tanigawa T Tarnawski AS 《The American journal of pathology》2007,170(4):1219-1228