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Atsushi?IshibeEmail authorView authors OrcID profile Mitsuyoshi?Ota Shoichi?Fujii Yusuke?Suwa Shinsuke?Suzuki Hirokazu?Suwa Masashi?Momiyama Jun?Watanabe Kazuteru?Watanabe Masataka?Taguri Chikara?Kunisaki Itaru?Endo 《Surgical endoscopy》2017,31(10):3890-3897
Background
Laparoscopic surgery has been widely accepted for the treatment of colorectal cancer; however, long-term outcomes in elderly patients remain controversial. The midterm results of a randomized trial comparing open surgery with laparoscopic surgery in elderly patients with colorectal cancer are presented.Methods
This was a randomized trial comparing open surgery with laparoscopic surgery in elderly patients with colorectal cancer. The primary outcome was complication rate, and secondary outcomes included 3-year recurrence-free survival and overall survival. A total of 200 patients were randomly assigned to open surgery or laparoscopic surgery between 2008 and 2012. The main study objective was to compare the midterm outcomes of open surgery with those of laparoscopic surgery in elderly patients with colorectal cancer. This trial is registered with Clinical Trials.gov (NCT01862562).Results
There were no differences between the laparoscopic surgery group and open surgery group in the 3-year overall survival rate (91.5% for laparoscopic surgery vs. 90.6% for open surgery, p?=?0.638) or the 3-year recurrence-free survival rate (84.8% for laparoscopic surgery vs. 88.2% for open surgery, p?=?0.324). The local recurrence rate was significantly higher in the laparoscopic surgery group than in the open surgery group in rectal cancer (13.8% for laparoscopic surgery vs. 0% for open surgery, p?=?0.038). In subgroup analysis according to tumor location, there were no significant differences in the 3-year overall survival rate or 3-year recurrence-free survival rate between the two treatment groups.Conclusion
The midterm outcomes of laparoscopic surgery are similar to those of open surgery in elderly patients with colorectal cancer.73.
Yasunori Hattori MD Kazuteru Doi MD Kazuo Kaneko MD Tan Soo Heong MD 《The Journal of hand surgery》1998,23(6):1034-1037
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H Nishihira Y Toyoda Y Tanaka R Ijiri N Aida M Takeuchi K Ohnuma H Kigasawa K Kato T Nishi 《Journal of clinical oncology》2000,18(16):3012-3017
PURPOSE: To describe various favorable courses of neuroblastoma (NBL) detected by mass screening and to present our observation program as a temporary treatment option, to be used until a final decision is made regarding the mass screening program for 6-month-old infants. PATIENTS AND METHODS: Between October 1993 and November 1999, 26 of 51 patients with NBL detected by mass screening were enrolled in our observation program. The criteria for observation included urinary vanillylmandelic acid (VMA) and homovanillic acid (HVA) levels less than 50 microg/mg creatinine, smaller tumor size (< 5.0 cm), preoperative status, and granted informed consent. Patients were divided into four groups according to changes in urinary VMA and HVA values and tumor size. Patients who no longer fulfilled criteria underwent surgery. RESULTS: The observation period ranged from 4 to 73 months. Urinary VMA and HVA levels decreased in 19 of 26 patients, often by age 16 months. Eighteen patients had regressing tumors, and in 10 of these cases, the tumor was undetectable or barely detectable by imaging techniques. Four patients younger than 12 months had increased tumor marker levels and tumor volume, histologically reflecting neuroblastic proliferation. The remaining three patients, all older than 18 months, had varied tumor marker levels but increased tumor volume, histologically reflecting an increase in Schwann cells. No upgrading of tumor stage or unfavorable biologic factor was noted in any patient. CONCLUSION: None of our patients showed evidence of transition from favorable to unfavorable prognosis, a finding that points to a reduction in the significance of screening as a public health measure. Until results of ongoing screening trials involving older patients have been evaluated, the observation program can be used as a temporary measure to avoid, with little risk, unnecessary surgical intervention. 相似文献
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Rie Akaho Akiko Otsu Aiko Igarashi Yuko Aoki Takaubu Takemura Sayaka Kobayashi Kazuteru Ohashi Katsuji Nishimura 《Transplantation proceedings》2019,51(6):1990-1993
BackgroundThe psychological distress experienced by patients scheduled for hematopoietic stem cell transplantation (HSCT) is of clinical concern. However, distress experienced by patients scheduled for HLA-haploidentical HSCT vs that of patients scheduled for other types of matched HSCT is unknown. We conducted a retrospective study to clarify whether the type of HSCT influences the appearance of psychological distress in patients anticipating HSCT.MethodsOne hundred fifty-seven patients who had undergone any of 4 types of HSCT at Tokyo Metropolitan Komagome Hospital between October 2013 and September 2016 and had completed the Profile of Mood States (POMS) questionnaire within 2 weeks before the procedure were included. We computed T-scores for the tension-anxiety (TA) and depression (D) subscales, took scores ≥ 60 to represent mood disturbance of clinical concern, and examined scores and other clinical variables in relation to each procedure.ResultsTwenty-two (14.0%) patients had a POMS-TA score ≥ 60, and 26 (16.6%) had a POMS-D score ≥ 60. The numbers of POMS-TA and POMS-D scores ≥ 60 did not differ significantly with respect to age, sex, leukemia type, number of previous transplants, disease status, comorbidity index, or transplant type. A multivariate logistic regression analysis confirmed the absence of an influence of the type of HSCT on the incidence of POMS-TA or POMS-D scores ≥60.ConclusionAttention should be paid to the matter of psychological distress in patients with leukemia who will be treated by HSCT, even HLA-haploidentical HSCT. Such patients need psychological support, especially during the waiting period immediately prior to the transplantation procedure. 相似文献
77.
Safety and feasibility of liver resection with continued antiplatelet therapy using aspirin 下载免费PDF全文
78.
Jun?WatanabeEmail authorView authors OrcID profile Mitsuyoshi?Ota Makoto?Kawamoto Yago?Akikazu Yusuke?Suwa Hirokazu?Suwa Masashi?Momiyama Atsushi?Ishibe Kazuteru?Watanabe Hidenobu?Masui Kaoru?Nagahori 《International journal of colorectal disease》2017,32(3):391-398
Background
The effects of subcutaneous closed-suction Blake drain for preventing incisional surgical site infections (SSIs) after colorectal surgery have never been evaluated in a randomized controlled trial (RCT). Thus, we performed a RCT to evaluate the clinical benefits of using a subcutaneous closed-suction Blake drain in patients undergoing colorectal surgery.Method
Consecutive patients who underwent colorectal surgery were enrolled in this study. Patients were randomly assigned to the subcutaneous closed-suction drainage arm or the control (no subcutaneous drainage) arm. The primary endpoint was incidence rate of incisional SSIs. And, we performed logistic regression analysis to detect predictive factors for incisional SSIs after colorectal surgery.Results
From November 2012 to September 2014, a total of 240 patients were enrolled in this study. One-hundred-seventeen patients who were treated by the control arm and 112 patients by the subcutaneous drainage arm were judged to be eligible for analysis. The incidence of incisional SSIs rate was 8.7 % in the overall patients. The incidence of incisional SSIs rate was 12.8 % in the control arm and 4.5 % in the subcutaneous drainage arm. There was significantly reduction of the incidence in the subcutaneous drainage arm than in the control arm (p = 0.025). Logistic regression analysis demonstrated that thickness of subcutaneous fat >3.0 cm, forced expiratory volume in 1 s as percent of forced vital capacity (FEV1.0 %) >70 %, and subcutaneous drain were independent predictors of postoperative incisional SSIs (p = 0.008, p = 0.004, and p = 0.017, respectively).Conclusion
The results of our RCT suggest that a subcutaneous Blake drain is beneficial for preventing incisional SSIs in patients undergoing colorectal surgery.79.
Impact of total body irradiation on successful neutrophil engraftment in unrelated bone marrow or cord blood transplantation 下载免费PDF全文
Hideki Nakasone Fuji Shigeo Kimikazu Yakushijin Makoto Onizuka Akihito Shinohara Kazuteru Ohashi Koichi Miyamura Naoyuki Uchida Minoko Takanashi Tatsuo Ichinohe Yoshiko Atsuta Takahiro Fukuda Masao Ogata On Behalf of the Complication Working Group of Japanese Society for Hematopoietic Cell Transplantation 《American journal of hematology》2017,92(2):171-178
Total body irradiation (TBI) has been thought to promote donor cell engraftment in allogeneic hematopoietic cell transplantation (HCT) from alternative donors. However, recent progress in HCT strategies may affect the clinical significance of TBI on neutrophil engraftment. With the use of a Japanese transplant registry database, we analyzed 3933 adult recipients (>15 y.o.) who underwent HCT between 2006 and 2013 from an 8/8 HLA‐matched unrelated bone marrow donor (MUD, n = 1367), an HLA‐mismatched unrelated bone marrow donor (MMUD, n = 1102), or unrelated cord blood (CBT, n = 1464). Conditioning regimens were divided into five groups: High‐TBI‐(>8Gy), Low‐TBI‐ (≤8Gy), and no‐TBI‐myeloablative conditioning (MAC), and Low‐TBI‐ and no‐TBI‐reduced‐intensity conditioning (RIC). In both MUD and MMUD, neutrophil engraftment rate was >90% in each of the five conditioning groups, and TBI was not associated with prompt neutrophil engraftment in multivariate analyses. Conversely, in CBT, TBI regimens had a higher rate of day‐30 neutrophil engraftment than no‐TBI‐regimens: 78% in High‐TBI‐MAC, 83% in Low‐TBI‐MAC, and 76% in Low‐TBI‐RIC versus 65% in No‐TBI‐MAC, and 68% in No‐TBI‐RIC (P < .001). Multivariate analyses in CBT demonstrated that TBI‐regimens were significantly associated with a higher rate of neutrophil engraftment. Subsequently focusing on CBT patients alone, TBI‐regimens were significantly associated with a higher rate of neutrophil engraftment in patients who received CBT with a 4/6 or less HLA allele‐match, or who had anti‐HLA antibodies. In summary, TBI‐regimens had no impact on neutrophil engraftment in the current practice of unrelated bone marrow transplantation. However, in CBT, TBI is still necessary to enhance engraftment. 相似文献
80.