全文获取类型
收费全文 | 3020篇 |
免费 | 150篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 26篇 |
妇产科学 | 16篇 |
基础医学 | 288篇 |
口腔科学 | 32篇 |
临床医学 | 237篇 |
内科学 | 1230篇 |
皮肤病学 | 10篇 |
神经病学 | 125篇 |
特种医学 | 73篇 |
外科学 | 430篇 |
综合类 | 15篇 |
预防医学 | 43篇 |
眼科学 | 131篇 |
药学 | 146篇 |
中国医学 | 7篇 |
肿瘤学 | 378篇 |
出版年
2023年 | 20篇 |
2022年 | 59篇 |
2021年 | 107篇 |
2020年 | 48篇 |
2019年 | 61篇 |
2018年 | 86篇 |
2017年 | 53篇 |
2016年 | 96篇 |
2015年 | 70篇 |
2014年 | 92篇 |
2013年 | 122篇 |
2012年 | 223篇 |
2011年 | 232篇 |
2010年 | 127篇 |
2009年 | 111篇 |
2008年 | 161篇 |
2007年 | 257篇 |
2006年 | 197篇 |
2005年 | 178篇 |
2004年 | 183篇 |
2003年 | 202篇 |
2002年 | 173篇 |
2001年 | 17篇 |
2000年 | 16篇 |
1999年 | 22篇 |
1998年 | 45篇 |
1997年 | 22篇 |
1996年 | 30篇 |
1995年 | 22篇 |
1994年 | 23篇 |
1993年 | 20篇 |
1992年 | 13篇 |
1991年 | 19篇 |
1990年 | 14篇 |
1989年 | 15篇 |
1988年 | 9篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 10篇 |
1984年 | 11篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1980年 | 5篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1975年 | 2篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1968年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有3205条查询结果,搜索用时 15 毫秒
101.
Antibiotic prophylaxis for endoscopic retrograde chlangiopancreatography increases the detection rate of drug‐resistant bacteria in bile 下载免费PDF全文
102.
103.
104.
105.
106.
Yu-ichi Noto Sonoko Misawa Masahiro Mori Naoki Kawaguchi Kazuaki Kanai Kazumoto Shibuya Sagiri Isose Saiko Nasu Yukari Sekiguchi Minako Beppu Shigeki Ohmori Masanori Nakagawa Satoshi Kuwabara 《Clinical neurophysiology》2013,124(9):1893-1898
ObjectivesTo clarify whether patients with spinal muscular atrophy (SMA) or spinal and bulbar muscular atrophy (SBMA) suffer disabling muscle fatigue, and whether activity-dependent conduction block (ADCB) contributes to their fatigue. ADCB is usually caused by reduced safety factor for impulse transmission in demyelinating diseases, whereas markedly increased axonal branching associated with collateral sprouting may reduce the safety factor in chronic lower motor neuron disorders.MethodsWe assessed the fatigue severity scale (FSS) in 22 patients with SMA/SBMA, and in 100 disease controls (multiple sclerosis, myasthenia gravis, chronic inflammatory demyelinating polyneuropathy (CIDP), and axonal neuropathy). We then performed stimulated-single fibre electromyography (s-SFEMG) in the extensor digitorum communis (EDC) muscle of 21 SMA/SBMA patients, 6 CIDP patients, and 10 normal subjects.ResultsThe FSS score was the highest in SMA/SBMA patients [4.9 ± 1.1 (mean ± SD)], with 81% of them complaining of disabling fatigue, compared with normal controls (3.5 ± 1.0), whereas patients with multiple sclerosis (4.3 ± 1.6), myasthenia gravis (4.0 ± 1.6) or CIDP (4.3 ± 1.4) also showed higher FSS score. When 2000 stimuli were delivered at 20 Hz in s-SFEMG, conduction block of single motor axons developed in 46% of patients with SMA/SBMA, and 40% of CIDP patients, but in none of the normal controls.ConclusionSMA/SBMA patients frequently suffer from disabling fatigue presumably caused by ADCB induced by voluntary activity.SignificanceADCB could be the mechanism for muscle fatigue in chronic lower motor neuron diseases. 相似文献
107.
108.
Eguchi Y Hyogo H Ono M Mizuta T Ono N Fujimoto K Chayama K Saibara T;JSG-NAFLD 《Journal of gastroenterology》2012,47(5):586-595
Background
The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. This study aimed to assess the recent prevalence of NAFLD and to predict the prevalence of nonalcoholic steatohepatitis (NASH) with liver fibrosis using established scoring systems in the general population.Methods
A cross-sectional study was conducted among 8352 subjects who received health checkups from 2009 to 2010 in three health centers in Japan. Subjects with an intake over 20?g of alcohol/day or with other chronic liver diseases were excluded. Fatty liver was detected by ultrasonography. The probability of NASH with advanced fibrosis was calculated according to the body mass index, age, ALT, and triglyceride (BAAT) and FIB-4 (based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet counts) indices.Results
A total of 5075 subjects were enrolled. The overall prevalence of NAFLD was 29.7%. There was a significant threefold difference in the mean prevalence between males (41.0%) and females (17.7%). This prevalence showed a linear increase with body mass index, triglycerides, and low-density lipoprotein cholesterol regardless of threshold values, even without obesity. The estimated prevalence of NASH according to the BAAT index ≥3 was 2.7%, and according to the FIB-4 index it was 1.9%.Conclusions
The prevalence of NAFLD has increased in the general population, especially in males. There is a linear relationship between the prevalence of NAFLD and various metabolic parameters, even in nonobese subjects. The prevalence of NASH with advanced fibrosis is estimated to be considerably high in subjects with NAFLD. 相似文献109.
110.
Terasaki M Tanaka S Oka S Nakadoi K Takata S Kanao H Yoshida S Chayama K 《Journal of gastroenterology and hepatology》2012,27(4):734-740
Background and Aims: Colorectal laterally spreading tumors (LST) > 20 mm are usually treated by endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR). Endoscopic piecemeal mucosal resection (EPMR) is sometimes required. The aim of our study was to compare the outcomes of ESD and EMR, including EPMR, for such LST. Methods: A total of 269 consecutive patients with a colorectal LST > 20 mm were treated endoscopically at our hospital from April 2006 to December 2009. We retrospectively evaluated the complications and local recurrence rates associated with ESD, hybrid ESD (ESD with EMR), EMR, and EPMR. Results: ESD and EMR were performed successfully for 89 and 178 LST, respectively: 61 by ESD; 28 by hybrid ESD; 70 by EMR; and 108 by EPMR. Between‐group differences in perforation rates were not significant. Local recurrence rates in cases with curative resection were as follows: 0% (0/56) in ESD; 0% (0/27) in hybrid ESD; 1.4% (1/69) in EMR; and 12.1% (13/107) in EPMR; that is, significantly higher in EPMR. No metastasis was seen at follow up. The recurrence rate for EPMR yielding ≥ three pieces was significantly high (P < 0.001). All 14 local recurrent lesions were adenomas that were cured endoscopically. Conclusions: As for safety, ESD/hybrid ESD is equivalent to EMR/EPMR. ESD/hybrid ESD is a feasible technique for en bloc resection and showed no local recurrence. Although local recurrences associated with EMR/EPMR were seen, which were conducted based on our indication criteria, all local recurrences could obtain complete cure by additional endoscopic treatment. 相似文献