全文获取类型
收费全文 | 3104篇 |
免费 | 150篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 29篇 |
妇产科学 | 19篇 |
基础医学 | 317篇 |
口腔科学 | 32篇 |
临床医学 | 239篇 |
内科学 | 1234篇 |
皮肤病学 | 10篇 |
神经病学 | 139篇 |
特种医学 | 78篇 |
外科学 | 444篇 |
综合类 | 15篇 |
预防医学 | 44篇 |
眼科学 | 131篇 |
药学 | 148篇 |
中国医学 | 7篇 |
肿瘤学 | 385篇 |
出版年
2023年 | 20篇 |
2022年 | 60篇 |
2021年 | 108篇 |
2020年 | 48篇 |
2019年 | 61篇 |
2018年 | 88篇 |
2017年 | 54篇 |
2016年 | 98篇 |
2015年 | 71篇 |
2014年 | 92篇 |
2013年 | 123篇 |
2012年 | 224篇 |
2011年 | 232篇 |
2010年 | 127篇 |
2009年 | 111篇 |
2008年 | 162篇 |
2007年 | 259篇 |
2006年 | 198篇 |
2005年 | 180篇 |
2004年 | 184篇 |
2003年 | 202篇 |
2002年 | 174篇 |
2001年 | 19篇 |
2000年 | 19篇 |
1999年 | 26篇 |
1998年 | 45篇 |
1997年 | 22篇 |
1996年 | 30篇 |
1995年 | 24篇 |
1994年 | 23篇 |
1993年 | 20篇 |
1992年 | 21篇 |
1991年 | 21篇 |
1990年 | 18篇 |
1989年 | 17篇 |
1988年 | 13篇 |
1987年 | 13篇 |
1986年 | 11篇 |
1985年 | 15篇 |
1984年 | 12篇 |
1983年 | 6篇 |
1982年 | 3篇 |
1980年 | 6篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1975年 | 3篇 |
1972年 | 2篇 |
1970年 | 5篇 |
1968年 | 2篇 |
1967年 | 2篇 |
排序方式: 共有3289条查询结果,搜索用时 15 毫秒
101.
Angiotensin II receptor blocker prevents increased arterial stiffness in patients with essential hypertension. 总被引:2,自引:0,他引:2
Jun Agata Daigo Nagahara Shuichi Kinoshita Yoshitoki Takagawa Norihito Moniwa Daisuke Yoshida Nobuyuki Ura Kazuaki Shimamoto 《Circulation journal》2004,68(12):1194-1198
BACKGROUND: High pulse wave velocity (PWV) is related to cardiovascular risk in essential hypertension (EHT). It is reported that short-term treatment with an angiotensin II receptor blocker (ARB) decreases PWV, as well as blood pressure (BP), and increases the serum adiponectin, known as an adipocytokine, which has an anti-atherosclerotic effect. However, it is not known whether long-term treatment with ARB prevents the increase in PWV independently of the reduction of BP, and whether adiponectin is related to the chronic effect of ARB on PWV. METHODS AND RESULTS: In order to examine the short-term effect of ARB on PWV, 9 subjects with EHT had PWV measured before and after treatment with an ARB for 1 month. The treatment significantly reduced PWV and BP. For evaluation of the long-term effect of ARB therapy, 56 consecutive subjects with EHT who were already taking anti-hypertensive drugs other than an angiotensin-converting enzyme inhibitor had their PWV measured. We divided the EHT subjects into 2 groups: (1) the ARB group (EHT treated with an ARB for at least 6 months) and (2) the control group (EHT treated with anti-hypertensive drugs other than an ARB). Although there was no significant difference between the 2 groups in BP, age or body mass index, the PWV value in the ARB group was significantly lower than that in the control group. Moreover, the serum adiponectin concentration in the ARB group was significantly higher than that in the control group. CONCLUSIONS: Long-term treatment with ARB inhibits the progression of arterial stiffness independent of BP reduction. One of the mechanisms may be related to the increased serum adiponectin concentration after treatment with an ARB. 相似文献
102.
103.
Kinoshita H Matsuda N Kaba H Hatakeyama N Azma T Nakahata K Kuroda Y Tange K Iranami H Hatano Y 《Hypertension》2008,52(3):507-513
The present study was designed to examine roles of the phosphatidylinositol 3-kinase-Akt pathway and reduced nicotinamide-adenine dinucleotide phosphate oxidases in the reduced ATP-sensitive K(+) channel function via superoxide produced by high glucose in the human artery. We evaluated the activity of the phosphatidylinositol 3-kinase-Akt pathway, as well as reduced nicotinamide-adenine dinucleotide phosphate oxidases, the intracellular levels of superoxide and ATP-sensitive K(+) channel function in the human omental artery without endothelium. Levels of the p85-alpha subunit and reduced nicotinamide-adenine dinucleotide phosphate oxidase subunits, including p47phox, p22phox, and Rac-1, increased in the membrane fraction from arteries treated with D-glucose (20 mmol/L) accompanied by increased intracellular superoxide production. High glucose simultaneously augmented Akt phosphorylation at Ser 473, as well as Thr 308 in the human vascular smooth muscle cells. A phosphatidylinositol 3-kinase inhibitor LY294002, as well as tiron and apocynin, restored vasorelaxation and hyperpolarization in response to an ATP-sensitive K(+) channel opener levcromakalim. Therefore, it can be concluded that the activation of the phosphatidylinositol 3-kinase-Akt pathway, in combination with the translocation of p47phox, p22phox, and Rac-1, contributes to the superoxide production induced by high glucose, resulting in the impairment of ATP-sensitive K(+) channel function in the human visceral artery. 相似文献
104.
Olmesartan ameliorates insulin sensitivity by modulating tumor necrosis factor-alpha and cyclic AMP in skeletal muscle. 总被引:2,自引:0,他引:2
Koichi Yamaguchi Nobuyuki Ura Hideyuki Murakami Nobuhiko Togashi Masaya Hyakukoku Katsuhiro Higashiura Kazuaki Shimamoto 《Hypertension research》2005,28(9):773-778
We have reported that tumor necrosis factor (TNF)-alpha in skeletal muscle is one of the determinants of insulin resistance and that the renin-angiotensin system may be related to the regulation of TNF-a in skeletal muscle. Recent studies have suggested the involvement of cyclic adenosine monophosphate (cAMP) in the regulation of TNF-a in vascular smooth muscle cells or monocytes. The aim of this study was to determine the relationship between cAMP and TNF-a in skeletal muscle in connection with the renin-angiotensin system. Six-week-old male Sprague-Dawley rats were fed either normal rat chow or fructose-rich chow for 6 weeks. For the last 2 weeks of a 6-week period, the rats were treated with a vehicle or with an angiotensin II type 1 receptor antagonist (olmesartan medoxomil, 0.1 mg/kg/day). TNF-alpha levels in the soleus muscle were significantly higher and cAMP levels in the soleus muscle were significantly lower in fructose-fed rats than in control rats. Olmesartan increased cAMP and reduced TNF-a simultaneously in fructose-fed rats. There was a significant negative correlation between levels of cAMP and TNF-alpha. Moreover, a cAMP analogue reduced TNF-a levels in the soleus muscle. These results indicate that the increase in TNF-alpha via suppression of cAMP may affect the induction of insulin resistance. In addition, the facts that olmesartan increased cAMP and decreased TNF-alpha suggest that a part of the TNF-alpha regulation by angiotensin II might consist of modulation of cAMP through Gi protein activation in skeletal muscle. 相似文献
105.
Yuji Matsuzawa Toru Kita Hiroshi Mabuchi Masunori Matsuzaki Noriaki Nakaya Shinichi Oikawa Yasushi Saito Jun Sasaki Kazuaki Shimamoto Hiroshige Itakura 《Circulation journal》2003,67(4):287-294
The Japan Lipid Intervention Trial (J-LIT) study, a nationwide cohort study utilizing the clinical practice of general physicians, was designed to clarify the relationship between the incidence of coronary heart disease and serum lipid concentrations during simvastatin therapy, as well as the safety of the therapy, in a large number of Japanese hypercholesterolemic patients. All the enrolled patients were treated with simvastatin. The current study analyzed the lipid lowering effect and safety of the low-dose simvastatin therapy used in the J-LIT study. Open-labeled simvastatin was given to 51,321 patients at an initial dose of mostly 5 mg/day. After 6 months of the treatment, the average serum total cholesterol (TC) and low density lipoprotein-cholesterol concentrations in all the patients followed up were reduced by 18.3% and 26.0%, respectively, and that of high density lipoprotein-cholesterol increased 2.3% on average. These concentrations were well maintained throughout the 6-year treatment period. A minority of patients (1.4%) unexpectedly had a remarkable reduction in TC concentration by more than 40%. Hyper-responders, even to low-dose statin, were found for the first time in this large-scale and long-term investigation. Overall adverse drug reactions occurred in 3.3% of subjects during the 6-year treatment, the major events being hepatic and musculoskeletal disorders, of which the incidence was less than 1%. Low-dose simvastatin therapy of 5 mg/day effectively controlled the serum TC concentration by reducing it by approximately 20% on average in hypercholesterolemic Japanese patients, a reduction that corresponds to the effect of simvastatin 20 mg/day in Western studies. In addition, the low incidence of drug-related adverse events in this study may be also related to the low dosage of simvastatin. 相似文献
106.
Washio M Saitoh S Arai Y Takagi S Oonishi H Isobe T Takeuchi H Oohata J Mori M Shimamoto K 《Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics》2005,42(2):221-228
OBJECTIVE: The present study was conducted in order to investigate risk factors for heavy burden of family caregivers. STUDY DESIGN: Cross-sectional study. PARTICIPANTS: 51 pairs of the frail elderly and their family caregivers in one town in Hokkaido. RESULTS: Compared to those with a lighter burden, family caregivers with heavier burden looked after the frail elderly with more behavior disturbances due to dementia. They cared for the elderly longer and had less time to go out without accompanying their charges than less burdened caregivers. On the other hand, the elderly had similar activities of daily living and degree of need of care between the two groups. In addition, physical caring time did not differ between the two groups. These findings suggest that the psychological burden may be more important than the physical burden. In addition, caregivers used only 30-40% of services they had the right to use with long-term care insurance. These findings suggest that more convenient services for users should be provided. 相似文献
107.
108.
Hideki Ota Hideki Kawai Makoto Sato Kazuaki Ito Satoshi Fujishima Hiroko Suzuki 《Journal of Physical Therapy Science》2015,27(3):859-864
[Purpose] The purpose of this study was to clarify the benefits of early mobilization for
mechanically ventilated patients for their survival to discharge to home from the
hospital. [Subjects and Methods] Medical records were retrospectively analyzed of patients
who satisfied the following criteria: age ≥ 18 years; performance status 0–2 and
independent living at their home before admission; mechanical ventilation for more than 48
h; and survival after mechanical ventilation. Mechanically ventilated patients in the
early mobilization (EM) group (n = 48) received mobilization therapy, limb exercise and
chest physiotherapy, whereas those in the control group (n = 60) received bed rest alone.
Univariate and multivariate logistic regression analyses were performed to identify
clinical variables associated with discharge disposition. [Results] Early mobilization was
a positive independent factor and the presence of neurological deficits was a negative
factor contributing to discharge to home. Among patients surviving mechanical ventilation
without neurological deficits, the rate of discharge to home was significantly higher
among patients in the EM group that in the control group (76% vs. 40%). [Conclusion] Early
mobilization can improve the rate of discharge to home of patients requiring mechanical
ventilation because of non-neurological deficits.Key words: Mechanical ventilation, Early mobilization, Physiotherapy 相似文献
109.
Noriaki Naeshiro Hideaki Kakizawa Hiroshi Aikata Hiromi Kan Hatsue Fujino Takayuki Fukuhara Tomoki Kobayashi Yohji Honda Daisuke Miyaki Tomokazu Kawaoka Masataka Tsuge Akira Hiramatsu Michio Imamura Yoshiiku Kawakami Hideyuki Hyogo Masaki Ishikawa Kazuo Awai Kazuaki Chayama 《Hepatology research》2014,44(7):740-749