Implementing a Stratified Vocational Advice Intervention for People on Sick Leave with Musculoskeletal Disorders: A Multimethod Process Evaluation

Journal of Occupational Rehabilitation - Purpose To perform a process evaluation of a stratified vocational advice intervention (SVAI), delivered by physiotherapists in primary care, for people on...     

The Potential of Anti-Bullying Efforts to Prevent Academic Failure and Youth Crime. A Case Using the Olweus Bullying Prevention Program (OBPP)

Prevention Science - The effectiveness of bullying prevention programs has led to expectations that these programs could have effects beyond their primary goals. By reducing the number of victims...     

The relationship of negative schizophrenia to parkinsonism

The positive-negative distinction of schizophrenia has emerged as a valid means of clarifying its heterogeneity. Despite evidence that the two symptom classes may reflect different dimensions of the disease, there is presently no integrated model for understanding of the pathophysiology of these symptoms and their co-occurrence in schizophrenia. We propose that negative phenomena of schizophrenia may be a variant of Parkinsonism. This view is supported by the overlap with Parkinsonism in terms of clinical features, neurochemistry, pharmacology, as well as neuroradiological and neuropathological aspects. As such, negative symptoms may be a manifestation of disease of the basal ganglia and constitute the core pathology in schizophrenia. Positive symptoms, conversely, may reflect an "accessory" process related to a compensatory increase in striatal and limbic dopamine activity following an injury to the dopaminergic system. In the present communication we present a series of studies that support the association of negative schizophrenia and Parkinsonism. Based on this evidence, we suggest that schizophrenic patients with prominent negative symptoms might be managed like patients with Parkinson's disease, namely, with dopaminergic drugs and MAO-B inhibitors. Finally, the association of negative schizophrenia with Parkinsonism raises the possibility that adrenal medullary tissue transplantation, which may benefit a selected group of Parkinsonian patients, may be a future promising therapy for refractory negative schizophrenia.     

Cyclical use of tamoxifen and high-dose medroxyprogesterone acetate in advanced estrogen receptor positive breast cancer

Summary One-hundred and seventy patients with estrogen receptor positive (10 pmol/g protein) advanced breast cancer have been treated in a prospective randomized study either with continuous tamoxifen 30 mg × 1 daily (TAM), or with TAM 30 mg × 1 daily for 8 weeks alternating with medroxyprogesterone acetate 500 mg × 2 daily for 8 weeks (TAM/HD-MPA). The response rate was 62% in the group treated with cyclic TAM/HD-MPA versus 41% in the TAM alone group (p = 0.02). There was no significant difference in duration of remissions or survival.     

Late complications with the Pritchard Mark II elbow prosthesis

Twenty-three consecutive patients with rheumatoid arthritis who had 26 Pritchord Mark II elbow prostheses were followed prospectively with a mean follow-up of 75 months (range 52 to 101 months). Two patients with three elbow prostheses have died, leaving 21 patients with 23 elbow prostheses for review. At the latest follow-up all the nonrevised elbows had achieved good or excellent results concerning pain relief and elbow motion. According to the data analyzed by a survivorship function-a Kaplan-Meier curve-the early results were promising with 92% of the prostheses surviving the first 5 years; however, only 43% of the prostheses have survived 8 years. Seven prostheses have been revised; the reasons for revision include one infection, one humeral fracture, one loosening of the humeral component, and four disconnections of the hinge. The number with disconnection of the hinge is increasing. Of 16 prostheses still not revised, the x-ray film reveals migration of the pin axle in six. Radiographic signs of component loosening or migration of the axle are not reflected in pain, function, or total score of the elbow.     

A cost-effectiveness analysis of cervical cancer screening: health policy implications

This paper presents a framework for comparison of screening programme designs, based on efficiency and cost effectiveness criteria. The design parameters, such as choice of screening interval, which population segments to screen and expected participation rates in the selected population segments, are varied simultaneously. The costs and effects for a range of existing and hypothetical screening programmes against cervical cancer are estimated, using a mathematical simulation model. On the basis of these estimates average costs per life year and marginal costs per life year are calculated for a range of programmes. These calculations result in the definition of a range of inefficient programmes. Moreover, it is illustrated that the cost effectiveness of the efficient screening programmes decreases at an increasing rate as programmes are intensified either by way of shortening the screening interval or extending the target population segment to encompass the very young and/or the very old. The conclusion of this paper is that one should probably not extend screening programmes against cervical cancer beyond screening women in the age group 25-59 years every 4 years. In addition, increasing the participation rate of this group is a more cost effective way of increasing the number of life years gained, rather than extending the target group or decreasing the screening interval.     

Harnessing Our Energy: A Counterpoint to “Breaking Away”

Maternal and Child Health Journal -     

Telemedicine in north-west Russia

During the last few years, telemedicine based on simple, low-cost technology has increased significantly in the Arkhangelsk region of north-west Russia. Specialists at the regional hospital of Arkhangelsk are diagnosing patients from local hospitals 600-700 km from the capital. A still-image system is used for emergency cases. The same technology, along with telephones with loudspeakers, is also used to provide distance learning at the regional hospitals of Arkhangelsk and Troms?. This article describes the results from the telemedicine collaboration between the University Hospital of Troms? and health-care institutions in Arkhangelsk, and discusses the experience gained.