全文获取类型
收费全文 | 41899篇 |
免费 | 3174篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 404篇 |
儿科学 | 1122篇 |
妇产科学 | 1110篇 |
基础医学 | 7074篇 |
口腔科学 | 806篇 |
临床医学 | 4348篇 |
内科学 | 8207篇 |
皮肤病学 | 729篇 |
神经病学 | 3677篇 |
特种医学 | 1793篇 |
外国民族医学 | 1篇 |
外科学 | 5451篇 |
综合类 | 292篇 |
一般理论 | 29篇 |
预防医学 | 3759篇 |
眼科学 | 723篇 |
药学 | 2883篇 |
中国医学 | 53篇 |
肿瘤学 | 2653篇 |
出版年
2023年 | 402篇 |
2022年 | 167篇 |
2021年 | 543篇 |
2020年 | 573篇 |
2019年 | 653篇 |
2018年 | 1132篇 |
2017年 | 1083篇 |
2016年 | 1146篇 |
2015年 | 1019篇 |
2014年 | 1036篇 |
2013年 | 1900篇 |
2012年 | 2574篇 |
2011年 | 2748篇 |
2010年 | 1305篇 |
2009年 | 862篇 |
2008年 | 2315篇 |
2007年 | 2380篇 |
2006年 | 2232篇 |
2005年 | 2040篇 |
2004年 | 1902篇 |
2003年 | 1845篇 |
2002年 | 1798篇 |
2001年 | 1050篇 |
2000年 | 1206篇 |
1999年 | 741篇 |
1998年 | 315篇 |
1997年 | 261篇 |
1996年 | 224篇 |
1995年 | 207篇 |
1994年 | 200篇 |
1993年 | 208篇 |
1992年 | 286篇 |
1991年 | 312篇 |
1990年 | 296篇 |
1989年 | 300篇 |
1988年 | 313篇 |
1987年 | 272篇 |
1986年 | 282篇 |
1985年 | 308篇 |
1984年 | 279篇 |
1983年 | 234篇 |
1982年 | 199篇 |
1981年 | 200篇 |
1979年 | 189篇 |
1978年 | 162篇 |
1977年 | 176篇 |
1976年 | 148篇 |
1975年 | 143篇 |
1973年 | 136篇 |
1938年 | 136篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations 总被引:2,自引:0,他引:2
J F Silverman D J Dabbs H T Norris W J Pories J Legier S Kay 《The American journal of surgical pathology》1986,10(8):539-545
Two examples of localized primary amyloid tumor of the breast are presented, including one patient with metachronous bilateral lesions. Our findings and review of the literature indicate that this rare lesion occurs predominantly in elderly females and can be mammographically and clinically confused with carcinoma. Fine-needle aspiration biopsy can be a useful procedure to make a preliminary diagnosis. Congo red staining with prior potassium permanganate incubation confirmed the AL type of amyloid in our two cases; this might be the predominant type in the localized form involving the breast. Immunofluorescence studies demonstrated IgA, with kappa and lambda light-chain deposition within the amyloid foci in one case, and intracytoplasmic IgG with both light chains within plasma cells and amyloid deposits of the second case. Ultrastructural examination of one of the cases showed characteristic findings of straight, nonbranching fibrils of 4-9 nm, diagnostic of amyloid. From our findings and a review of the literature, we conclude that amyloid tumors of the breast can occur in three separate settings: secondary amyloidosis, systemic or multiple myeloma associated amyloidosis, and as a localized primary type having a benign course. 相似文献
52.
53.
Leah L. Albers Deborah Anderson Leslie Cragin Susan Moore Daniels Christine Hunter Kay D. Sedler Dusty Teaf 《Journal of Midwifery & Women's Health》1996,41(4):269-276
We conducted an observational cohort study in three nurse-midwifery services to identify patient characteristics and clinical care measures related to perineal trauma at birth. Data were collected on all women who began care with a nurse-midwife in labor, using an adaptation of the Nurse-Midwifery Clinical Data Set (n = 3,049). Study variables included demographics, perineal management techniques and position for birth, and other intrapartum care and events. Univariate and multivariate analyses showed that episiotomy was strongly related to fetal bradycardia, prolonged second stage, ethnic status, and maternal education level. Warm compresses and flexion/counterpressure to slow delivery were protective. Spontaneous lacerations were influenced by these factors as well. The lateral position for birth was protective, and use of oils or lubricants and the lithotomy position increased lacerations. Multisite studies in nurse-midwifery practices may provide an ideal means of determining effective care measures in healthy populations. 相似文献
54.
T. Scholz Ø. Mathisen A. Bergan S. Osnes R. Innes T. Pedersen A. O. Aasen O. Søreide 《Transplant international》1997,10(3):180-184
We have introduced and evaluated several modifications of the conventional venovenous bypass (VVBP) in 29 adult patients
undergoing liver transplantation (OLT). A percutaneous technique for insertion of a jugular venous return cannula and a femoral
vein cannula was applied. The inferior mesenteric vein (IMV) was used for splanchnic decompression, which facilitated dissection
of the recipient liver and allowed portal anastomosis to be performed without disconnecting the portal bypass. A heat exchanger
was introduced into the bypass circuit to prevent heat loss. The percutaneous technique prevented complications related to
dissection in the axilla and groin. Hemodynamic characteristics corresponded to those found using the traditional technique.
Complications related to the VVBP were seen in only one patient in whom the femoral catheter was accidentally introduced into
the femoral artery. We conclude that percutaneous cannulas, use of the IMV for splanchnic decompression and the introduction
of a heat exchanger offer significant benefits and that they are safe and reliable.
Received: 23 August 1996 Received after revision: 14 January 1997 Accepted: 27 January 1997 相似文献
55.
Drug related hospital admissions 总被引:13,自引:0,他引:13
J. Hallas B. Harvald J. Worm J. Beck-Nielsen L. F. Gram E. Grodum N. Damsbo J. Schou H. Kromann-Andersen F. Frølund 《European journal of clinical pharmacology》1993,45(3):199-203
Summary As part of a high-intensity monitoring study of drug events as the cause of admission to departments of internal medicine, the effect of an educational intervention programme was studied. Two departments were included, one specialising in geriatrics and one that received patients by non-selected referral. The series consisted of 607 consecutive admissions studied before and 703 after the intervention. The drug events considered were adverse drug reactions and dose-related therapeutic failures, mainly due to non-compliance.A modest, statistically non-significant decrease in drug related hospital admissions (DRH) was seen, from 14% before to 13% after the intervention period. However, DRHs classified as definitely avoidable showed the significant decrease of 83%.There was no apparent relationship between the topics selected for the intervention programme and changes in the pattern of DRHs. No relationship between alterations in sales data and hospital admissions caused by a given drug could be demonstrated. A blinded external evaluation of case abstracts did not disclose any significant shift in the investigators' assessments.The intervention may have had an non-specific effect on avoidable DRHs. 相似文献
56.
Nephrotic syndrome in a mother and her infant: relationship with cytomegalovirus infection 总被引:1,自引:0,他引:1
Marisa Giani Alberto Edefonti Beatrice Damiani Giuseppina Marra Daniela Colombo Giovanni Banfi Emilio Rivolta Erich H. Strøm Michael Mihatsch 《Pediatric nephrology (Berlin, Germany)》1996,10(1):73-75
This case report describes infantile nephrotic syndrome (NS) in a baby girl with a clinically severe cytomegalovirus (CMV) infection. Culture of the baby's urine was positive for CMV and IgM anti-CMV antibodies were detected. After an unsuccessful course of corticosteroids, gancyclovir treatment was started and a remission of cutaneous, pulmonary, and renal symptoms was achieved. As the mother also developed NS at the end of pregnancy, a common etiology could be postulated, although there were no signs of recent CMV infection in the mother, only anti-CMV IgG. The relationship between CMV infection and glomerular disease is still unclear: NS may represent another manifestation of CMV disease. 相似文献
57.
58.
Ductal adenoma of the breast 总被引:1,自引:0,他引:1
Ductal adenoma is a recently described benign tumour of the breast that can be mistaken for carcinoma in both frozen and paraffin sections. Such a case is presented. Fortunately a mastectomy was not performed, but the patient did undergo axillary node dissection. Surgeons and pathologists should familiarize themselves with this lesion so that patients do not have to undergo unnecessary mastectomies and axillary node dissections. 相似文献
59.
C. R. Goucke MB ChB FFARACS J. P. Keaveny MB BCh BAO FFARCS B Kay DMSc MB ChB FFARCS T. E. J. Healy MSc MD FFARCS M. Ryan MB ChB FFARCS 《Anaesthesia》1990,45(4):329-331
Eighty-two outpatients who received general anaesthesia for surgical removal of maxillary or mandibular third molars were given either diclofenac 75 mg or nefopam 20 mg intramuscularly for postoperative pain control. They and the control group were also allowed oral paracetamol as required. The results showed that there was no significant pain relief from these single intramuscular injections. 相似文献
60.
K. Brøsen L. F. Gram P. N. Nielsen K. Brusgaard K. Skjødt 《European journal of clinical pharmacology》1994,47(3):221-225
CYP2D6 genotyping was carried out by XbaI restriction fragment length polymorphism analysis and polymerase chain reaction in 168 healthy Danish volunteers, 77 extensive metabolizers (EM) and 91 poor metabolizers (PM) of sparteine. All EM were genotyped correctly as heterozygous or homozygous for the functional (wild type) gene, D6-wt. However, the D6-wt gene was apparently also present in 11 (12%) of the PM who accordingly were incorrectly genotyped as EM. The specificity of genotyping PM thus was 100% but the sensitivity was only 88%. The most common allele was the D6-wt with an apparent frequency of 0.741 (0.026) in the Danish population and the second most common allele was the D6-B with an apparent frequency of 0.194 (0.024). The median (range) of the sparteine metabolic ratio (MR) in 47 homozygous D6-wt EM was 0.28 (0.11–4.10) and the corresponding value in heterozygous EM was 0.36 (0.11–9.10). The median difference was 0.09 (95% confidence interval: 0.02–0.16). CYP2D6 phenotyping is a promising tool in tailoring the individual dose of tricyclic antidepressants, some neuroleplics and some antiarrhythmics. However if the genotype test could be improved with regard to both sensitivity in PM and the ability to predict CYP2D6 activity in EM then it would be of even greater clinical value in therapeutic drug monitoring. 相似文献