全文获取类型
收费全文 | 10244篇 |
免费 | 1091篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 72篇 |
儿科学 | 225篇 |
妇产科学 | 272篇 |
基础医学 | 1733篇 |
口腔科学 | 219篇 |
临床医学 | 1317篇 |
内科学 | 2189篇 |
皮肤病学 | 85篇 |
神经病学 | 880篇 |
特种医学 | 315篇 |
外国民族医学 | 1篇 |
外科学 | 1311篇 |
综合类 | 156篇 |
一般理论 | 7篇 |
预防医学 | 1081篇 |
眼科学 | 132篇 |
药学 | 518篇 |
中国医学 | 11篇 |
肿瘤学 | 831篇 |
出版年
2022年 | 72篇 |
2021年 | 173篇 |
2020年 | 96篇 |
2019年 | 158篇 |
2018年 | 170篇 |
2017年 | 142篇 |
2016年 | 167篇 |
2015年 | 185篇 |
2014年 | 248篇 |
2013年 | 411篇 |
2012年 | 544篇 |
2011年 | 568篇 |
2010年 | 365篇 |
2009年 | 310篇 |
2008年 | 530篇 |
2007年 | 549篇 |
2006年 | 551篇 |
2005年 | 477篇 |
2004年 | 477篇 |
2003年 | 514篇 |
2002年 | 457篇 |
2001年 | 228篇 |
2000年 | 216篇 |
1999年 | 197篇 |
1998年 | 130篇 |
1997年 | 112篇 |
1996年 | 114篇 |
1995年 | 86篇 |
1994年 | 85篇 |
1993年 | 80篇 |
1992年 | 191篇 |
1991年 | 192篇 |
1990年 | 189篇 |
1989年 | 155篇 |
1988年 | 176篇 |
1987年 | 134篇 |
1986年 | 170篇 |
1985年 | 164篇 |
1984年 | 112篇 |
1983年 | 123篇 |
1982年 | 68篇 |
1981年 | 72篇 |
1979年 | 98篇 |
1978年 | 70篇 |
1977年 | 76篇 |
1976年 | 74篇 |
1974年 | 73篇 |
1973年 | 87篇 |
1971年 | 68篇 |
1970年 | 69篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
Do frail, disabled, poor, and very old Medicare beneficiaries have higher hospital charges? 总被引:2,自引:0,他引:2
To determine whether basing payments on diagnosis related groups (DRGs) results in mispayment for certain classes of patients, we examined the relation between total Medicare charges per hospitalization and eight beneficiary characteristics (including admission from a nursing home, extreme age, Medicaid enrollment, and disability). We controlled for the hospital in which care was given and the DRG to which the discharge was assigned. The largest effects were that average charges were 6.7% higher for beneficiaries who were disabled before the age of 65 years, and 6.2% higher for patients admitted from a nursing home; charges were 1.5% lower for Medicare beneficiaries who were also enrolled in Medicaid, 3.8% higher for those older than 80 years, and 1.3% lower for those older than 85 years compared with those aged from 80 to 84 years. Because these differences are very small compared with the average variation within DRGs, we conclude that using these beneficiary characteristics in the DRG classification system would only slightly improve DRGs. Medicare's DRG-based payments seem to be substantially equitable with regard to these beneficiary characteristics. 相似文献
13.
100 years of ‘Allergy’: can von Pirquet's word be rescued? 总被引:1,自引:0,他引:1
A. B. Kay 《Clinical and experimental allergy》2006,36(5):555-559
Summary It is 100 years since Clemens von Pirquet wrote his classic paper introducing the term 'allergy'. Although the word is no longer used in the way he intended, his concept of 'changed reactivity' laid the foundation for the modern science of immunology. 相似文献
14.
15.
Michael Schenker Mikael Wiberg Simon P Kay Roland S Johansson 《Journal of plastic, reconstructive & aesthetic surgery》2007,60(1):13-23
Although toe-to-hand transfer has a defined role in the management of congenital hand deformities, it remains unclear how well children integrate the transferred digits into physiological grasping. We analysed fingertip forces in the precision grip of 13 patients when lifting a test object more than three years after free toe transfer for absent or hypoplastic digits. Clinically, most patients showed normal sensibility of transferred digits, but active motion and pinch strength were limited as compared to the normal hand. For the control of fingertip forces, two key features of the normal two-digit opposition grip were seen in all operated hands: adaptation of grip force to object weight and parallel coordination of lift and grip forces. These physiological grasping strategies developed independently of the patients' age at the time of operation, which ranged from one to 13 years. In four patients, we observed increased tangential load forces with the operated hand due to misalignments in the application of fingertips on the grasp surfaces. Such forces lead to increased grip force requirements on both fingers that may overload transferred digits with limited motor function. The need for optimal alignment of the grip axis during toe-transfer surgery is emphasised. 相似文献
16.
Mark A. Trimble Salvador Borges-Neto Stuart Smallhelser Ji Chen Emily F. Honeycutt Linda K. Shaw Jaekyeong Heo Robert A. Pagnanelli E. Lindsey Tauxe Ernest V. Garcia Fabio Esteves Frank Seghatol-Eslami G. Neal Kay Ami E. Iskandrian 《Journal of nuclear cardiology》2007,14(3):298-307
Background Cardiac resynchronization therapy (CRT) is approved for the treatment of patients with advanced systolic heart failure and
evidence of dyssynchrony on electrocardiograms. However, a significant percentage of patients do not demonstrate improvement
with CRT. Echocardiographic techniques have been used for more accurate determination of dyssynchrony. Single photon emission
computed tomography (SPECT) myocardial perfusion imaging has not previously been used to evaluate cardiac dyssynchrony. The
objective of this study is to evaluate mechanical dyssynchrony as described by phase analysis of gated SPECT images in patients
with left ventricular dysfunction, conduction delays, and ventricular paced rhythms.
Methods and Results A novel count-based method is used to extract regional systolic wall thickening amplitude and phase from gated SPECT images.
Five indices describing the phase dispersion of the onset of mechanical contraction are determined: peak phase, phase SD,
bandwidth, skewness, and kurtosis. These indices were determined in consecutive patients with left ventricular dysfunction
(n=120), left bundle branch block (n=33), right bundle branch block (n=19), and ventricular paced rhythms (n=23) and were
compared with normal control subjects (n=157). Phase SD, bandwidth, skewness, and kurtosis were significantly different between
patients with left ventricular dysfunction, left bundle branch block, right bundle branch block, and ventricular paced rhythms
and normal control subjects (all P<.001) Peak phase was significantly different between patients with right ventricular paced rhythms and normal control subjects
(P=.001).
Conclusions A novel SPECT technique for describing left ventricular mechanical dyssyn-chrony has been developed and may prove useful in
the evaluation of patients for CRT.
This study was funded in part by a research grant from the Medtronic-Duke Strategic Alliance, of which Dr Borges-Neto is the
primary investigator. 相似文献
17.
Thane Lawrie Catriona Matheson Christine Bond Kay Roberts 《The International journal on drug policy》2003,14(5-6):445
Community pharmacists contribution to the management of drug problems is considerable. As the use of illicit drugs has increased, pharmacists have come under increasing pressure to offer services to problem drug users. However, there is concern among some pharmacists that offering such services may deter other customers. There is particular concern among some pharmacists about needle exchange services. Only 9.5% of Scottish pharmacies offer needle exchange services compared to 69% which are dispensing methadone (57% of which supervise methadone consumption). Qualitative interviews were used in a purposive sample of 10 pharmacies in Scotland. Eight customers were interviewed in each pharmacy to ascertain pharmacy customers’ views on these services. The majority of customers were supportive of these services. Customers were often unaware that the pharmacy they were interviewed in was offering services for people with drug problems. Pharmacy customers were more knowledgeable about, and more supportive, of needle exchange services than they were of methadone. This was because they believed needle exchange services helped to reduce the amount of discarded needles in public places. Pharmacy customers also recognised that needle exchange helped reduce the spread of disease. These findings should be used to encourage more pharmacists to offer needle exchange services. 相似文献
18.
Despite current intensive research, the pathophysiology of tardive dyskinesia (TD), a serious neurological side effect of neuroleptic treatment, is poorly understood. Prompted by the observation of an increased incidence and severity of abnormal perioral movements in neuroleptic-treated pinealectomized, as compared to intact rats, we suggested that the pineal gland exerts a protective effect which mitigates against the development of TD and, by inference, that reduced melatonin secretion may be related to the pathophysiology of TD. To investigate this proposition further, we studied the association of TD with pineal calcification (PC) on CT scan in chronic schizophrenic patients. Our findings revealed a significant association between TD and PC and suggest, furthermore, that PC may be a neuroradiological marker of TD. Since PC may reflect diminished secretory activity of the gland, these findings support the hypothesis that the pathophysiology of TD is linked to disturbances of melatonin secretion. The clinical and therapeutic implications of these novel findings are discussed. In the following communication, in which we introduce the hypothesis that disturbances of 5-HT and melatonin secretion are related to the pathophysiology of TD. Subsequently, we present a series of studies which relate to the association of TD with PC. We conclude by presenting the hypothesis that disturbances in melatonin secretion may also be relevant to the pathophysiology of Tourette's syndrome. 相似文献
19.
Psychiatric morbidity in Hobart's dependent aged 总被引:1,自引:0,他引:1
D W Kay T A Holding B Jones S Littler 《The Australian and New Zealand journal of psychiatry》1987,21(4):463-475
Psychiatric morbidity in the dependent aged was studied in the elderly population of Hobart's nursing homes and long-stay hospitals. Only patients with home addresses in Hobart and who were admitted for the first time aged 70 years or over were included. Three hundred and twelve persons were interviewed with a standard interview, and an informant was interviewed when appropriate. The medical records were searched for diagnoses and drug treatments. Physical disability was rated on an ad hoc scale. Comparisons were made of the prevalence of dementia, depression and anxiety in different types of unit, and between these and two domiciliary samples, one of which received domiciliary nursing services (n = 100) and the other not (n = 100). The differential use of institutions by men and women, and a possible sex difference in the prevalence of dementia is discussed. 相似文献
20.
Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations 总被引:2,自引:0,他引:2
J F Silverman D J Dabbs H T Norris W J Pories J Legier S Kay 《The American journal of surgical pathology》1986,10(8):539-545
Two examples of localized primary amyloid tumor of the breast are presented, including one patient with metachronous bilateral lesions. Our findings and review of the literature indicate that this rare lesion occurs predominantly in elderly females and can be mammographically and clinically confused with carcinoma. Fine-needle aspiration biopsy can be a useful procedure to make a preliminary diagnosis. Congo red staining with prior potassium permanganate incubation confirmed the AL type of amyloid in our two cases; this might be the predominant type in the localized form involving the breast. Immunofluorescence studies demonstrated IgA, with kappa and lambda light-chain deposition within the amyloid foci in one case, and intracytoplasmic IgG with both light chains within plasma cells and amyloid deposits of the second case. Ultrastructural examination of one of the cases showed characteristic findings of straight, nonbranching fibrils of 4-9 nm, diagnostic of amyloid. From our findings and a review of the literature, we conclude that amyloid tumors of the breast can occur in three separate settings: secondary amyloidosis, systemic or multiple myeloma associated amyloidosis, and as a localized primary type having a benign course. 相似文献