全文获取类型
收费全文 | 4506篇 |
免费 | 302篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 187篇 |
妇产科学 | 149篇 |
基础医学 | 734篇 |
口腔科学 | 23篇 |
临床医学 | 273篇 |
内科学 | 906篇 |
皮肤病学 | 124篇 |
神经病学 | 206篇 |
特种医学 | 141篇 |
外科学 | 540篇 |
综合类 | 184篇 |
一般理论 | 2篇 |
预防医学 | 361篇 |
眼科学 | 209篇 |
药学 | 474篇 |
中国医学 | 43篇 |
肿瘤学 | 239篇 |
出版年
2023年 | 22篇 |
2022年 | 61篇 |
2021年 | 109篇 |
2020年 | 58篇 |
2019年 | 77篇 |
2018年 | 108篇 |
2017年 | 72篇 |
2016年 | 95篇 |
2015年 | 113篇 |
2014年 | 163篇 |
2013年 | 187篇 |
2012年 | 348篇 |
2011年 | 366篇 |
2010年 | 174篇 |
2009年 | 142篇 |
2008年 | 258篇 |
2007年 | 227篇 |
2006年 | 249篇 |
2005年 | 219篇 |
2004年 | 205篇 |
2003年 | 193篇 |
2002年 | 162篇 |
2001年 | 136篇 |
2000年 | 118篇 |
1999年 | 95篇 |
1998年 | 64篇 |
1997年 | 34篇 |
1996年 | 28篇 |
1995年 | 31篇 |
1994年 | 35篇 |
1993年 | 30篇 |
1992年 | 64篇 |
1991年 | 62篇 |
1990年 | 51篇 |
1989年 | 46篇 |
1988年 | 40篇 |
1987年 | 35篇 |
1986年 | 37篇 |
1985年 | 32篇 |
1984年 | 29篇 |
1983年 | 28篇 |
1982年 | 13篇 |
1979年 | 14篇 |
1978年 | 17篇 |
1977年 | 16篇 |
1976年 | 16篇 |
1975年 | 17篇 |
1974年 | 13篇 |
1973年 | 19篇 |
1972年 | 13篇 |
排序方式: 共有4820条查询结果,搜索用时 15 毫秒
101.
102.
Chatterjee T Dixit A Mohapatra M Tyagi S Gupta PK Mishra P Bhattacharya M Karan AS Pati HP Saxena R Choudhry VP 《European journal of haematology》2004,73(2):93-97
Myelodysplastic syndromes (MDS) are clonal haematopoietic stem cell disorders characterised by ineffective and dyspoietic haematopoiesis. The natural history of these disorders is variable and ranges from a chronic to a rapid course towards leukaemic progression. Certain shortcomings have been encountered in the French-American-British (FAB) classification over the years, and therefore there is a need for an alternative method of classification. In 1999, the WHO published a revised classification of MDS. In the present study, we have analysed the clinical, haematological and histomorphological features in 96 cases of primary MDS seen in the department of haematology at the All India Institute of Medical Sciences (AIIMS) over a 6-yr period (1996-2001). Both FAB and WHO classifications have been incorporated and the Bournemouth scoring system applied in each case at presentation. The Bournemouth scoring system, in the absence of a cytogenetic study, offers a good prognostication and long-term survival estimate. 相似文献
103.
104.
105.
106.
Background
It is difficult to obtain adequate tissue sample for diagnosing autoimmune pancreatitis (AIP) with the help of traditional EUS-guided FNA. As per ICDC guidelines, EUS-guided FNA is not recommended for diagnosing AIP(1). We herein present a report of 2 cases of using a new flexible 22 gauge (G) core biopsy needle (SharkCore, Medtronic, Sunnydale, Calif) for diagnosing AIP.Methods
This is a report of 2 cases reviewed retrospectively which had used 22G core biopsy needle for obtaining histo-pathological samples for diagnosing AIP. The cases were reviewed with both endoscopist and a pathologist to determine if the diagnostic criteria were met.Results
Both the cases had adequate tissue sample obtained to make a clear diagnosis of AIP. Pathology showed changes of chronic pancreatitis with atrophy and storiform pattern of fibrosis with a dense lymphoplasmacytic infiltrate in both cases along with identification of IgG4 cells.Conclusion
EUS-guided fine needle biopsy (FNB) using the SharkCore needle can be used reliably for diagnosing AIP. More studies need to be performed to validate this further. 相似文献107.
This report describes the case of a young man who presented with right bundle-branch block and second degree atrioventricular block; intermittent episodes of Wenckebach periods were recorded. His bundle electrograms demonstrated progressive prolongation of the HV interval followed by block occurring distal to His. This report emphasizes the fact that the Wenckebach phenomenon as a manifestation of the distal conducting system disease can occur in young adults. The observations lend credence to the concept that Lenègre's disease can occur in young people. 相似文献
108.
Aadish Rawat Parikshit Singh Anupam Jyoti Sanket Kaushik Vijay Kumar Srivastava 《Chemical biology & drug design》2020,96(2):731-744
Amoebiasis is a parasitic infectious disease caused by the enteric protozoan Entamoeba histolytica, a leading basis of deaths accounted to parasites, succeeding malaria and schistosomiasis. Conventional treatment methodologies used to deal with amoebiasis mainly rely on the administration of anti‐amoebic compounds and vaccines but are often linked with substantial side‐effects on the patient. Besides, cases of development of drug resistance in protozoans have been recorded, contributing further to the reduction in the efficiency of the treatment. Loopholes in the efficacious management of the disease call for the development of novel methodologies to manage amoebiasis. A way to achieve this is by targeting the essential metabolic processes of ‘encystation’ and ‘excystation’, and the associated biomolecules, thus interrupting the biphasic life cycle of the parasite. Technologies like the CRISPR‐Cas9 system can efficiently be exploited to discover novel and essential molecules that regulate the protozoan's metabolism, while efficiently manipulating and managing the known drug targets, leading to an effective halt and forestall to the enteric infection. This review presents a perspective on these essential metabolic processes and the associated molecules that can be targeted efficaciously to prevent the transmission of amoebiasis, thus managing the disease and proving to be a fruitful endeavour. 相似文献
109.
The work demonstrated a successful synthesis of nitric oxide (NO)-releasing material and its antibacterial effect on Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA). The polymeric support composed of thermosensitive Pluronic F68 having good biocompatibility and branched polyethylenimine (BPEI) housed N-diazeniumdiolates (NONOates) which could store and release NO under appropriate physiological condition. The developed F68–BPEI–NONOates releases a sufficient amount of NO under physiological condition to elicit effective killing of E. coli, S. aureus and MRSA. The antibacterial ability of the released NO was compared to untreated control or unmodified F68 polymer by using confocal microscopy; F68–BPEI–NONOates demonstrated excellent antibacterial activity with in vitro low cytotoxicity. TEM investigation also revealed the destruction of bacteria membrane caused by NO. The effectiveness of F68–BPEI–NONOates against resistant strains such as MRSA provides a very simple but highly efficient strategy to combat drug-resistant bacterial infections. 相似文献