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31.
Heltai K Kis Z Burian K Endresz V Veres A Ludwig E Gönczöl E Valyi-Nagy I 《Atherosclerosis》2004,173(2):339-346
The relative significance of traditional risk factors, chronic infections and autoimmune processes in the development of acute myocardial infarction (AMI) has not been fully elucidated. We compared serum IgG antibody titres to various pathogens, i.e. Chlamydia pneumoniae (Cpn), cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1), and to the potential autoantigens human heat shock protein 60 (hHSP60) and mycobacterial heat shock protein 65 (mHSP65), in serum samples obtained from patients 3-48 h after AMI (n = 40) or stable effort angina (SEA, n = 43), and from controls (n = 46). The strongest association was observed between AMI and the elevated level of hHSP60 antibodies. The association between AMI and the level of Cpn antibodies was also significant. High levels of hHSP60 and Cpn antibodies represented independent risk factors for the development of AMI, but the simultaneous presence of high levels of antibodies to Cpn and hHSP60 suggested a joint effect on the relative risk of AMI (OR = 12.0-21.1). The antibody titres to mHSP65 were higher in the SEA group than in the controls, and the simultaneous presence of high levels of Cpn and mHSP65 antibodies meant an increased risk among the SEA patients. The antibody titres to CMV or HSV-1 were similar in the three groups. In conclusion, these results demonstrate associations of AMI with high levels of anti-hHSP60 and anti-Cpn antibodies, and of SEA with the level of anti-mHSP65 antibodies, these being independent risk factors. 相似文献
32.
A recurrent synonymous KAT6B mutation causes Say‐Barber‐Biesecker/Young‐Simpson syndrome by inducing aberrant splicing 下载免费PDF全文
33.
Katalin Czifrák József Karger‐Kocsis Lajos Daróczi Miklós Zsuga Sándor Kéki 《Macromolecular chemistry and physics.》2014,215(19):1896-1907
A series of novel segmented linear and crosslinked polyurethanes (PUs) are synthesized from poly(ε‐caprolactone) (PCL) (25 kg mol?1), methylene diphenyl diisocyanate (MDI), and various polyether diols (Pluronic (PLU) and polyethylene glycol (PEG)). The basic structures of the highly deformable PUs are PLU/PEG–MDI–PCL–MDI–PLU/PEG and PLU–MDI–PCL–MDI–PLU, respectively. The linear and crosslinked PUs are characterized. Changes in the tensile behavior are attributed to the effects of compositional variables and alterations in the crosslink density. Additional information on the morphology of the segmented PUs is deduced from differential scanning calorimetry, as well as transmission and scanning electron microscopy investigations. Both the linear and the crosslinked PUs exhibit a broad rubbery plateau above the melting temperature of the crystalline PCL phase, which is highly beneficial for shape memory function. This work highlights that the chemical build‐up of soft segments containing high‐molecular‐weight crystallizable chain units is a proper tool to tailor the morphology and mechanical properties of PUs, and thus also their shape memory properties.
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Fadila Hadj-Bouziane Ning Liu Andrew H. Bell Katalin M. Gothard Wen-Ming Luh Roger B. H. Tootell Elisabeth A. Murray Leslie G. Ungerleider 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(52):E3640-E3648
Significance
Successful social interaction depends on the ability to recognize others, evaluate their mental states (e.g. intentions, desires, and beliefs), and “read” their emotional states. Here, we show that, in monkeys, damage to the amygdala, a brain structure that is central to the expression of emotion, significantly disrupts the processing of emotional facial expression in high-level visual cortical areas involved in face recognition. These findings suggest that the projections of the amygdala to visual cortical areas likely enhance the sensory processing of biologically important signals, including those related to potential environmental threats and social contexts. 相似文献36.
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Aron Cseh Kristof Mark Farkas Laszlo Derzbach Katalin Muller Barna Vasarhelyi Balazs Szalay Andras Treszl Viktor Farkas 《Neurological sciences》2013,34(7):1151-1155
Aseptic inflammation due to activated immune cells has been implicated in the pathomechanism of migraine. We measured the prevalence of regulatory T cells (Tregs), along with that of CD4+/CD8+ lymphocytes and their Th1/Th2 commitment in pediatric migraine. Children and adolescents suffering from migraine without aura, migraine with aura and hemiplegic migraine ictally (n = 53, 27, and 20, respectively), also interictally (n = 33) were recruited and compared to 24 healthy children. Our results indicated comparable prevalence of Tregs, CD4+ and Th1/Th2 committed cells. CD8+ prevalence was lower, and CD4+/CD8+ ratio was higher in ictal phase irrespective of the subtype of migraine. No association between CD8+ prevalence and gender, body weight, disease onset and attack duration in migraine subtypes was found. CD8+ prevalence was normal in patients in interictal phase. These results suggest the absence of major systemic alteration of adaptive immunity in children and adolescents suffering from migraine; however, a transient decrease of CD8+ prevalence during the ictal phase was detected irrespective of the subtype of migraine. 相似文献
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