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101.
Kartik S. Sundareswaran MS David H. Frakes PhD Mark A. Fogel MD Dennis D. Soerensen MS John N. Oshinski PhD Ajit P. Yoganathan PhD 《Journal of magnetic resonance imaging : JMRI》2009,29(1):155-165
Purpose
To develop and validate a multidimensional segmentation and filtering methodology for accurate blood flow velocity field reconstruction from phase‐contrast magnetic resonance imaging (PC MRI).Materials and Methods
The proposed technique consists of two steps: (1) the boundary of the vessel is automatically segmented using the active contour approach; and (2) the noise embedded within the segmented vector field is selectively removed using a novel fuzzy adaptive vector median filtering (FAVMF) technique. This two‐step segmentation process was tested and validated on 111 synthetically generated PC MRI slices and on 10 patients with congenital heart disease.Results
The active contour technique was effective for segmenting blood vessels having a sensitivity and specificity of 93.1% and 92.1% using manual segmentation as a reference standard. FAVMF was the superior technique in filtering out noise vectors, when compared with other commonly used filters in PC MRI (P < 0.05). The peak wall shear rate calculated from the PC MRI data (248 ± 39 sec?1), was significantly decreased to (146 ± 26 sec?1) after the filtering process.Conclusion
The proposed two‐step segmentation and filtering methodology is more accurate compared to a single‐step segmentation process for post‐processing of PC MRI data. J. Magn. Reson. Imaging 2009;29:155–165. © 2008 Wiley‐Liss, Inc.102.
103.
Mainak Mukhopadhyay Nandini Chatterjee Pranab Maity Kartik Patar 《Indian Journal of Critical Care Medicine》2014,18(2):110-112
Spontaneous rupture of the spleen with hemoperitoneum is a very rare, but serious manifestation of dengue fever (DF). We report a case of a young female who was presented with atraumatic abdominal pain, hypovolemic shock, anemia, ascites and hepatosplenomegaly with a recent history of a febrile illness. Subsequent investigations proved the presence of hemoperitoneum with spontaneous splenic rupture with seropositivity for DF. Early diagnosis and conservative management in this case resulted in a favorable outcome. 相似文献
104.
Kartik Dhaduk Jagjit Khosla Muzna Hussain Vrunda Mangaroliya Shaylika Chauhan Kumar Ashish Rahul Gupta Suman Pal 《World Journal of Virology》2022,11(4):170-175
Vaccination for coronavirus disease 2019 (COVID-19) is a critical strategy in controlling the current pandemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). After widespread COVID-19 vaccine imple-mentation, isolated case reports about myocarditis as a potential adverse reaction started coming. As of November 12, 2021, Centers for Disease Control and Prevention (CDC) has reported 1793 cases of myocarditis or pericarditis among young people with age 12-29 years, most cases have been reported in the male adolescent age group after the second dose of mRNA COVID-19 vaccines. It is very important to monitor the safety standards and adverse reactions of vaccines to effectively implement the vaccination policies. The CDC and the United States Food and Drug Administration actively monitor vaccine-associated adverse reactions a well-known platform such as Vaccine Adverse Event Reporting System. CDC continues to recommend COVID-19 vaccines and booster doses for eligible individuals (age limit according to the type of vaccine) after careful consideration from risk-benefit assessment and favorable outcomes from vaccination. Mechanisms behind COVID-19 vaccine-induced myocarditis are not clear yet but several possibilities such as molecular mimicry between the spike protein of SARS-CoV-2 and self-antigens, immune response to mRNA, and activation of host immunological system, trigger of the pre-existing dysregulated immunological system have been documented in the literature. Overall, data suggests a good prognosis, especially in young patients. In this review article, we cover currently available data on COVID-19 vaccine-related myocarditis incidence, concerns, possible mechanisms of myocarditis, current treatment, and outcome trends, risk vs benefit assessment of COVID-19 vaccination in this current pandemic. 相似文献
105.
Kartik G Krishnan Gabriele Schackert Ralf Steinmeier 《British journal of plastic surgery》2005,58(3):330-338
Indocyanine green near-infrared-video angiography (ICG-NIR-VA) was recently introduced for measuring perfusion of skin flaps. The prognostic value of this method with regards to post-transfer manipulations of the flap, and subsequently, flap survival is not adequately documented in the literature. In this paper, we report our experience with the ICG-NIR-VA in the intraoperative evaluation and post-operative follow-up of nine flaps (2 large random pattern, 4 pedicled island and 3 free flaps) used in various reconstructive procedures. Two flaps (1 random pattern and 1 free flap) showed delayed intraoperative uptake in ICG-NIR-VA. In the post-operative phase, (days 1-3) six flaps (1 random pattern, 2 axial pattern and 3 free flaps) showed a delay both in the ICG-NIR-VA uptake, as well as clearance. However, a clinical correlate was observed only in 2 of the 6 flaps demonstrating this delay: general and partial venous congestion was seen in a distally based interosseous posterior flap and a free lateral arm flap respectively. Leeches were implemented only based on the clinical signs. In one distally based perforator flap, the decision on perfusion augmentation via microanastomosis was based on the intraoperative ICG-NIR-VA finding. All flaps showed uneventful healing. Based on our observations, the question arises, not whether the ICG-NIR-VA is sensitive for the prognosis of venous congestion, upon which the flap manipulation strategy might rest-but whether it is too sensitive. Further, prospective studies are necessary. 相似文献
106.
Amar Mukund Kartik Mittal Aniket Mondal Shiv Kumar Sarin 《Journal of vascular and interventional radiology : JVIR》2018,29(6):790-799
Purpose
To assess overall outcome and midterm transplant-free survival of patients with Budd-Chiari syndrome (BCS) undergoing radiologic interventions including anatomic recanalization of the hepatic vein (HV) and inferior vena cava (IVC) and direct intrahepatic portosystemic shunt (DIPS) creation, both as combined and as independent groups.Materials and Methods
From November 2010 to October 2014, 136 patients with BCS were treated with HV/IVC recanalization (group 1) or DIPS creation (group 2). Both groups were periodically analyzed for stent patency on Doppler ultrasound, clinical outcome, biochemical parameters, and survival until death, liver transplantation, or last clinical evaluation.Results
Actuarial transplant-free survival for the entire cohort was 94% at 1 year and 5 years with no significant difference in overall survival. There was significant biochemical improvement in group 1 with decrease in mean serum bilirubin level (1.8 mg/dL to 1.4 mg/dL, P < .011), mean serum aspartate aminotransferase (48.6 IU/L to 33.2 IU/L, P < .05), and mean serum alanine aminotransferase (38.7 IU/L to 28.5 IU/L) and increase in mean serum albumin level (3.2 g/dL to 3.45 g/dL, P < .001) after 3 and 24 months. There were 4 deaths in each group at 1-year follow-up; all 4 patients had acute fulminant BCS at presentation.Conclusions
Radiologic interventions for BCS lead to remarkable improvement of liver function and a good overall outcome and midterm transplant-free survival. Patients receiving anatomic recanalization show improved liver synthetic functions compared with patients treated with DIPS. 相似文献107.
Lorena Ostios-Garcia Jennifer Faig Giulia C. Leonardi Anika E. Adeni Safiya J. Subegdjo Christine A. Lydon Deepa Rangachari Mark S. Huberman Kartik Sehgal Meghan Shea Paul A. VanderLaan Matthew P. Cheng Francisco M. Marty Sarah P. Hammond Daniel B. Costa Mark M. Awad 《Journal of thoracic oncology》2018,13(7):1037-1042
Introduction
Despite widespread administration of programmed death receptor 1 (PD-1) pathway inhibitors among individuals with NSCLC, little is known about the safety and activity of these agents among human immunodeficiency virus (HIV) – infected patients since this population has largely been excluded from immunotherapy clinical trials.Methods
Here, we describe seven patients with metastatic NSCLC and HIV infection who were treated with PD-1 inhibitors nivolumab (two cases) or pembrolizumab (five cases with three in the first-line setting).Results
Partial responses to immune checkpoint inhibitors were observed in three of seven cases. Among four patients with a programmed death ligand-1 tumor proportion score ≥50%, three partial responses were observed. All patients received antiretroviral therapy while on anti–PD-1 treatment. None of the patients experienced grade 3 or 4 immune-related adverse events or immune reconstitution inflammatory syndrome, and none required PD-1 inhibitor dose interruption or discontinuation due to toxicity.Conclusions
Nivolumab and pembrolizumab can be safe and effective among patients with NSCLC and HIV. Larger studies will be needed to determine the overall safety and efficacy of immune checkpoint inhibitors among cancer patients with HIV. 相似文献108.
Brian M. Capogna Kartik Shenoy Thomas Youm Steven A. Stuchin 《The Journal of arthroplasty》2017,32(10):3249-3255
Background
Most patients who undergo total hip arthroplasty are very satisfied with their outcomes. However, there is a small subset of patients who have persistent pain after surgery. The etiology of pain after total hip arthroplasty varies widely; however, tendon disorders are a major cause of debilitating pain that often go unrecognized.Methods
We performed a literature review to identify the most common tendon pathologies after total hip arthroplasty which include iliopsoas tendinitis, greater trochanteric pain syndrome, snapping hip syndrome, and abductor tendinopathy.Results
We present a simplified approach highlighting the presentation and management of patients with suspected tendinopathies after total hip arthroplasty. These tendinopathies are treatable, and management begins with nonoperative modalities; however, in cases not responsive to conservative management, operative intervention may be necessary.Conclusion
Tendinopathies after total hip arthroplasty sometimes go unrecognized but when treated can result in higher surgeon and patient satisfaction. 相似文献109.
Rebecca A. Krukowski Delia West Marisha DiCarlo Kartik Shankar Mario A. Cleves Eric Tedford Aline Andres 《Maternal and child health journal》2017,21(3):485-491
Objectives Excessive gestational weight gain (GWG) is a key modifiable risk factor for negative maternal and child health. We examined the efficacy of a behavioral intervention in preventing excessive GWG. Methods 230 pregnant women (87.4 % Caucasian, mean age = 29.2 years; second parity) participated in the longitudinal Glowing study (clinicaltrial.gov #NCT01131117), which included six intervention sessions focused on GWG. To determine the efficacy of the intervention in comparison to usual care, participants were compared to a matched contemporary cohort group from the Arkansas Pregnancy Risk Assessment Monitoring Survey (PRAMS). Results Participants attended 98 % of intervention sessions. Mean GWG for the Glowing participants was 12.7 ± 2.7 kg for normal weight women, 12.4 ± 4.9 kg for overweight women, and 9.0 ± 4.2 kg for class 1 obese women. Mean GWG was significantly lower for normal weight and class 1 obese Glowing participants compared to the PRAMS respondents. Similarly, among those who gained excessively, normal weight and class 1 obese Glowing participants had a significantly smaller mean weight gain above the guidelines in comparison to PRAMS participants. There was no significant difference in the overall proportion of the Glowing participants and the proportion of matched PRAMS respondents who gained in excess of the Institute of Medicine GWG guidelines. Conclusions for Practice This behavioral intervention was well-accepted and attenuated GWG among normal weight and class 1 obese women, compared to matched participants. Nevertheless, a more intensive intervention may be necessary to help women achieve GWG within the Institute of Medicine’s guidelines. 相似文献
110.
Sanjiv Sharma Kartik Ganga 《Journal of vascular and interventional radiology : JVIR》2019,30(6):956-960
Integrating interventional radiology (IR) into clinical practice faces challenges in emerging countries in Asia and Africa. Overcoming them requires innovative solutions customized to local needs. After an in-depth gap analysis of these challenges, we began an organized skill development initiative in late 2015 offering radiologists and their supporting staff fully paid scholarships for IR training. Its concept, structure, and progress are reported here. This initiative covered 8 countries, IR specialists (n = 51), senior residents (n = 24), and 15 educational events (training institute [n = 3]; participating countries [n = 12]). This initiative is intended to develop a global network of trained personnel who can support IR programs in challenging locations of emerging countries. 相似文献