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91.
Background
The Internet in general and digital social networks in particular are increasingly important sources for health information; this also applies to information in the context of treatment of patients wishing for a baby. Initial studies show that patients are not only looking for factual information but also for emotional support. Whether digital social networks add to or compete with classical information and consulting is still unclear.Methods
In order to provide a preliminary answer to this question, a literature study was conducted to determine relevant empirical findings regarding the use of the Internet and digital social networks. This was done using a keyword search in literature databases and then keyword snowballing.Results
Information and advice from the Internet and from digital social networks can be seen as an addition to medical expertise, but are not a substitute. Digital social networks, in particular, supplement social peer groups and the relationship with physicians and will become even more important in the future.Conclusion
For professionals active in the field of reproductive medicine, this could be an indication of deficits with regard to counseling and treatment, which in the future might be countered by providing new services.92.
Evgeny A. Idelevich Matthias Hoy Dennis Knaack Dennis Görlich Georg Peters Matthias Borowski Karsten Becker 《International journal of antimicrobial agents》2018,51(2):221-226
Delays in appropriate antimicrobial treatment contribute to increased mortality of septic patients. We aimed to develop a methodology for detection of carbapenem resistance in Gram-negative bacteria directly from positive blood cultures (BCs). Initially, meropenem-resistant Enterobacteriaceae (n?=?13) and Pseudomonas aeruginosa (n?=?32) isolates as well as the same numbers of meropenem-susceptible isolates were used to establish the detection of carbapenem resistance from agar cultures. Growth-based phenotypic detection of meropenem resistance was performed by a laser scattering (LS) method using a BacterioScan?216R instrument. A subset of the strain collection consisting of meropenem-susceptible and -resistant isolates (each comprising seven P. aeruginosa and three Klebsiella pneumoniae) was used for determination of carbapenem resistance directly from positive BCs. Lysis/centrifugation and filtration/dilution methods were investigated for processing of positive BCs. Four different statistical approaches to discriminate between susceptible and resistant bacteria in real-time were applied and were compared regarding their sensitivity and specificity. After 3?h and 4?h of incubation, respectively, detection of carbapenem resistance in Enterobacteriaceae (sensitivity, 100%; specificity, 100%) and P. aeruginosa (sensitivity, 100%; specificity, ≥90%) agar cultures was attainable. Detection of carbapenem resistance directly from positive BCs was achievable with 100% sensitivity and 100% specificity after 4?h and 5?h, respectively, applying lysis/centrifugation and filtration/dilution methods. In conclusion, LS technology combined with lysis/centrifugation and appropriate statistical real-time analyses represents a promising option for rapid detection of carbapenem resistance in Gram-negative rods directly from positive BCs. 相似文献
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Olaf Holz Karsten Heusser Meike Müller Horst Windt Katharina Schwarz Christoph Schindler 《Journal of toxicology and environmental health. Part A》2018,81(13):576-588
Increased adverse health effects in older subjects due to exposure to ambient air pollutants may be related to the inflammatory response induced by these contaminants. The aim of this study was to assess airway and systemic inflammatory responses in older healthy subjects to a controlled experimental exposure with spark-generated elemental carbon black ultrafine particles (cbUFPs) and ozone (O3). Twenty healthy subjects, age 52–75 years, were exposed on three occasions separated by at least 8 weeks. The exposures to filtered air (FA), to cbUFP (50 μg/m3), or to cbUFP in combination with 250 ppb ozone (cbUFP + O3) for 3 h with intermittent exercise were performed double blind, and in random order. Sputum and blood samples were collected 3.5 h after each exposure. Exposure to cbUFP + O3 significantly increased plasma club cell protein 16 (CC16), the number of sputum cells, the number and percent of sputum neutrophils, and sputum interleukin 6 and matrix metalloproteinase 9. Exposure to cbUFP alone exerted no marked effect, except for an elevation in sputum neutrophils in a subgroup of 13 subjects that displayed less than 65% sputum neutrophils after FA exposure. None of the inflammatory markers was correlated with age, and serum cardiovascular risk markers were not markedly affected by cbUFP or cbUFP + O3. Exposure to cbUFP+O3 induced a significant airway and systemic inflammatory response in older healthy volunteer subjects. The effects induced by cbUFP alone suggest that the inflammation was predominantly mediated by O3, although one cannot rule out that the interaction of cbUFP and O3 played a role. 相似文献
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Kenneth Hugdahl Karsten Specht Eva Biringer Susanne Weis Rebecca Elliott Åsa Hammar Lars Ersland Anders Lund 《Cognitive therapy and research》2007,31(2):147-160
Nine patients with unipolar major depression were scanned with MRI twice over a 2-year period, and compared with 12 healthy
control subjects. All patients fulfilled criteria for major depressive disorder, recurrent type, at first scanning. Level
of depressive psychopathology was assessed by the Hamilton Depression Rating Scale. The participants had to work on a mental
arithmetics/working memory task while in the MR scanner. The task consisted of single digits (1 to 9) that were shown to the
participant, who had to add the numbers in successive pairs and press a response button when the sum was 10. Neuronal activation
was recorded based on the BOLD contrast phenomenon in a functional MRI protocol. The results showed significant increase in
activation for the patients in the inferior frontal gyrus and the superior and inferior parietal lobule at the second compared
with the first MR scanning session. There were also significant correlations between the HDRS scores and neuronal activation
which showed a negative correlation particularly in the inferior frontal and parietal lobe areas, which overlapped with similar
areas activated in the healthy control participants. This may indicate normalization of brain activation in depressed patients
as a function of time from an illness phase to a remission/recovery state.
相似文献
Kenneth HugdahlEmail: |
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Ingrid Lunde Sara Bremer Karsten Midtvedt Beata Mohebi Miriam Dahl Stein Bergan Anders Åsberg Hege Christensen 《European journal of clinical pharmacology》2014,70(6):685-693