全文获取类型
收费全文 | 4828篇 |
免费 | 389篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 96篇 |
妇产科学 | 118篇 |
基础医学 | 571篇 |
口腔科学 | 78篇 |
临床医学 | 550篇 |
内科学 | 1083篇 |
皮肤病学 | 52篇 |
神经病学 | 311篇 |
特种医学 | 148篇 |
外国民族医学 | 1篇 |
外科学 | 1025篇 |
综合类 | 88篇 |
一般理论 | 2篇 |
预防医学 | 294篇 |
眼科学 | 137篇 |
药学 | 290篇 |
中国医学 | 13篇 |
肿瘤学 | 352篇 |
出版年
2023年 | 44篇 |
2022年 | 107篇 |
2021年 | 194篇 |
2020年 | 95篇 |
2019年 | 158篇 |
2018年 | 174篇 |
2017年 | 150篇 |
2016年 | 142篇 |
2015年 | 163篇 |
2014年 | 227篇 |
2013年 | 249篇 |
2012年 | 424篇 |
2011年 | 399篇 |
2010年 | 206篇 |
2009年 | 177篇 |
2008年 | 264篇 |
2007年 | 258篇 |
2006年 | 266篇 |
2005年 | 255篇 |
2004年 | 208篇 |
2003年 | 224篇 |
2002年 | 184篇 |
2001年 | 65篇 |
2000年 | 56篇 |
1999年 | 50篇 |
1998年 | 36篇 |
1997年 | 21篇 |
1996年 | 20篇 |
1995年 | 19篇 |
1994年 | 12篇 |
1993年 | 12篇 |
1992年 | 31篇 |
1991年 | 28篇 |
1990年 | 23篇 |
1989年 | 22篇 |
1988年 | 16篇 |
1987年 | 13篇 |
1986年 | 13篇 |
1985年 | 11篇 |
1984年 | 16篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1979年 | 10篇 |
1977年 | 10篇 |
1976年 | 14篇 |
1975年 | 10篇 |
1974年 | 10篇 |
1973年 | 13篇 |
1972年 | 22篇 |
1971年 | 21篇 |
排序方式: 共有5237条查询结果,搜索用时 15 毫秒
121.
122.
Laurence Ladrière Karim Louchami Aouatif Laghmich Francine Malaisse-Lagae Willy J. Malaisse 《Endocrine》2001,14(3):383-397
Under conditions of sustained hyperglycemia, glycogen accumulates in pancreatic islets, but not so in acinar pancreatic cells.
We investigated whether advantage could be taken of such a situation in the perspective of the noninvasive imaging of the
endocrine pancreas. Control rats or animals injected with streptozotocin (STZ) were infused with solutions of d-glucose mixed with a tracer amount of d-[U-14C]glucose, and the radio-active glycogen content of both liver and pancreas was then measured. After 48 h of infusion, the
radio-active glycogen content of the pancreas was 30 times lower in STZ rats than in control animals, coinciding with a 50
times lower insulin content. In the control rats, a sizable labeling of pancreatic glycogen was also recorded when d-[U-14C]glucose was infused for only the last 4 h of unlabeled d-glucose infusion; such a labeling was not decreased when the animals were further infused for 1 h with only the unlabeled
hexose. Moreover, a pronounced difference in the pancreatic gland and blood radioactive content of control rats was still
observed when the hyperglycemic animals were killed only 40 min after the iv injection of d-[U-14C]glucose. In STZ rats transplanted with islets and later infused with d-[U-14C]glucose, the total radioactive content and radioactive glycogen content were both much higher in the transplanted islets
than in the pancreatic gland. These results allow one to define the conditions under which the administration of either 2-deoxy-2-[18F]fluoro-d-glucose or 11C-labeled d-glucose could conceivably be used to favor the selective labeling of the endocrine, as distinct from exocrine, pancreas. 相似文献
123.
124.
125.
126.
127.
Thierry Boulain Julie Boisrame-Helms Stephan Ehrmann Jean-Baptiste Lascarrou Adrien Bouglé Arnaud Chiche Karim Lakhal Stéphane Gaudry Sébastien Perbet Arnaud Desachy Séverin Cabasson Isabelle Geneau Patricia Courouble Noémie Clavieras Pablo L. Massanet Frédéric Bellec Yoan Falquet François Réminiac Philippe Vignon Pierre-François Dequin Ferhat Meziani 《Intensive care medicine》2015,41(2):248-256
128.
Karim R. Saab Jessica Kendrick Joseph M. Yracheta Miguel A. Lanaspa Maisha Pollard Richard J. Johnson 《Journal of the American Society of Nephrology : JASN》2015,26(2):247-257
African Americans are at increased risk for cardiovascular and metabolic diseases, including obesity, high BP, diabetes, CKD, myocardial infarction, and stroke. Here we summarize the current risks and provide an overview of the underlying risk factors that may account for these associations. By reviewing the relationship between cardiovascular and renal diseases and the African-American population during the early 20th century, the historic and recent associations of African heritage with cardiovascular disease, and modern population genetics, it is possible to assemble strong hypotheses for the primary underlying mechanisms driving the increased frequency of disease in African Americans. Our studies suggest that underlying genetic mechanisms may be responsible for the increased frequency of high BP and kidney disease in African Americans, with particular emphasis on the role of APOL1 polymorphisms in causing kidney disease. In contrast, the Western diet, particularly the relatively high intake of fructose-containing sugars and sweetened beverages, appears to be the dominant force driving the increased risk of diabetes, obesity, and downstream complications. Given that intake of added sugars is a remediable risk factor, we recommend clinical trials to examine the reduction of sweetened beverages as a primary means for reducing cardiovascular risk in African Americans. 相似文献
129.
A. S. Karim S. R. Reese N. A. Wilson L. M. Jacobson W. Zhong A. Djamali 《American journal of transplantation》2015,15(11):2888-2899
130.
Arroyo Diego Gasche Yvan Banfi Carlo Stiasny Brian Bendjelid Karim Giraud Raphaël 《Journal of cardiothoracic surgery》2015,10(1):1-8
Previously designed intra-thoracic paraaortic counterpulsation device has limited stroke volume and may depress the lung to cause complications. The purpose of this study was to evaluate the hemodynamic effects of an extra-thoracic paraaortic counterpulsation device (ETPACD) in comparison to intraaortic balloon pump (IABP) in an animal model with acute heart failure. The acute heart failure model was successfully induced by snaring branch of anterior descending coronary artery in sheep (weighting, 38-50 kg, n = 8). The ETPACD is a single port, 65-ml stroke volume blood chamber designed to be connected to descending aorta through a valveless graft and placed extra-thorax. In comparison, a standard clinical 40-ml IABP was placed in the descending aorta. The hemodynamic indices of both devices were recorded during counterpulsation assistance. Two of the sheep were allowed to survive for 1 week to examine the prolonged effect. Both ETPACD and IABP increased cardiac output with higher effect of ETPACD (13.52 % vs. 8.19 % in IABP, P < 0.05) and on mean diastolic aortic pressure (26.73 % vs. 12.58 % in IABP, P < 0.01). Both ETPACD and IABP also produced a greater reduction in left ventricular end-diastolic pressure (26.77 % vs. 23.08 %, P > 0.05). The ETPACD increased left carotid artery flow more significantly the IABP (18.00 % vs. 9.19 % , P < 0.05). In two of the sheep allowed to survive for 1 week, the device worked well with no complications and there was no thrombus formation in the chamber of ETPACD. This study demonstrated that both ETPACD and IABP provided benefit of circulatory support in acute heart failure with better effect on hemodynamic parameters provided by ETPACD. Therefore, ETPACD with theoretical larger stroke volume may become a promising counterpulsation device for treatment of heart failure. 相似文献