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731.
目的:评价肝移植术后患者血清总胆汁酸水平、胆酸/鹅脱氧胆酸比值在肝移植术后发生排斥反应及肝功能延迟恢复时的变化规律。方法:选择2004-01/2004-12在大连医科大学器官移植中心进行肝移植手术的患者28例,同时收集大连医科大学附属二院门诊健康体检者和肝硬化患者血清学标本各12例作为对照,所有观察对象均知情同意。采用高效液相色谱检测肝移植术后患者血清中不同种类胆汁酸及总胆汁酸水平,也与常规肝功能监测指标谷草转氨酶和总胆红素加以比较,对肝移植术后患者血清指标与肝功能恢复之间的关系进行综合评价。结果:所有观察对象均进入结果分析,无脱落。①肝硬化组、肝移植组术前患者的血清总胆汁酸水平显著高于正常对照组(P<0.05)。②肝移植患者术后发生排斥反应或肝功能延迟恢复时,血清总胆汁酸水平较术前明显升高(P<0.05),胆酸/鹅脱氧胆酸比值明显降低(P<0.05),且比谷草转氨酶、总胆红素的变化提前发生,随着供肝功能的恢复它们将逐渐恢复正常。结论:总胆汁酸及胆酸/鹅脱氧胆酸比率可以作为肝移植术后发生排斥反应及肝功能延迟恢复的早期诊断指标,其对于肝移植术后急性排斥反应的早期诊断、早期治疗有重大意义。 相似文献
732.
PM Mannucci ; K Schimpf ; T Abe ; LM Aledort ; K Anderle ; DB Brettler ; MW Hilgartner ; PB Kernoff ; M Kunschak ; CW McMillan ; et al. 《Transfusion》1992,32(2):134-138
A multicenter prospective study was carried out to evaluate whether a vapor-heated factor VIII concentrate transmitted blood-borne viral infections over a surveillance period of 15 months. Thirty-five patients with hemophilia and von Willebrand disease who had never received any blood components were treated. Twenty-eight were analyzed and found not to have non-A, non-B hepatitis. Sera from 20 of these 28 patients were also tested for the antibody to the hepatitis C virus. None had sero-converted during the follow-up period. None of the patients analyzed developed markers of the hepatitis B virus (n = 17) or the human immunodeficiency virus (n = 31). This vapor-heated factor VIII concentrate carries a low risk of transmitting hepatitis and human immunodeficiency virus infection. 相似文献
733.
Migraine in childhood and adolescence. A critical study of the diagnostic criteria and of the influence of age on clinical findings 总被引:1,自引:0,他引:1
JLD Gherpelli LM Nagae Poetscher AMMH Souza EMB Bosse GD Rabello A Diament M Scaff 《Cephalalgia : an international journal of headache》1998,18(6):333-341
We studied 253 children aged <15 years. Phase 1 included 193 children with migraine (1.1 and 1.2) divided into two groups (<10 and ≥ 10 years). We studied the relationship between age and migraine type, headache characteristics, and associated symptoms of the International Headache Society (IHS) definition. A higher frequency of migraine with aura, pulsatile quality, and unilateral location was observed in older children. In phase 2 we studied 176 children with headache (excluding migraine with aura), comparing diagnostic criteria, definition items, sensitivity, and specificity. The results showed that item B of the definition was the most frequent cause of exclusion in the 1.7 diagnostic group. Compared with Vahlquist and the IHS, the Prensky criteria were the most sensitive. Sensitivity was >70% for pain of moderate/severe intensity, duration between 2 and 48 h, isolated photophobia, isolated phonophobia, and aggravation with physical activity. Specificity was >70%, for nausea, vomiting, phonophobia and photophobia, isolated photophobia, aggravation with physical activity, and isolated phonophobia. Based on three alternative definitions, each modifying one item of the IHS definition, the sensitivity and specificity of these alternative definitions were compared with the "extended" criteria (children with migraine without aura and migrainous disturbance, according to the IHS criteria, grouped together). Exclusion of headache duration increased sensitivity by 10%, compared to restrictive IHS criteria, without decreasing specificity. 相似文献
734.
Bacterial meningitis in patients with nasopharyngeal carcinoma 总被引:2,自引:1,他引:2
Bacterial meningitis was found in 12 patients with nasopharyngeal
carcinoma, accounting for 0.65% of the 1850 patients with the tumour
diagnosed between 1981 and 1994 in our hospital. In 11 patients, the
time-lag between diagnosis of cancer and the appearance of infection ranged
from 9 months to 11 years (mean 57 months) whereas in one patient it was
only 5 days. Three patients developed mixed bacterial meningitis.
Cerebrospinal fluid culture for bacteria was positive in six patients.
Three patients (25%) were bacteraemic. Gram-negative bacilli, especially
Pseudomonas aeruginosa, were the most common pathogens. Age, sex and
histopathology were not risk factors for infection. Conditions predisposing
to meningitis included intracranial invasion of the tumor, neutropenia,
otitis media, and neurosurgical procedures. All but two patients had
intracranial tumour invasion and erosion of the base of the skull. Local
spread of micro-organism to the meninges was more important than
haematogenous spread. The overall mortality in our patients was 66.7%, much
higher than in patients without cancer.
相似文献
735.
Since compounds Ⅲ and Ⅳ possess retinoid-like action and analogues of Ⅰ inhibit some cancer cells ,seventeen derivatives of chlorophenoxy acetamide were synthesized.Of the seven compounds screened ,two exhibit cytostatic activity(1 and 2).Mass spectra showeda special expulsion of SO2 and CO from the sulfonamide compounds,Nuclear magnetic resonancesplitting patterns of these compounds also showed interesting features. 相似文献
736.
737.
正The leading form of dementia worldwide, Alzheimer 's disease(AD) is a common neurodegenerative disorder.The underlying causes of AD are not well understood, and no current treatments are preventing the onset or delay progression of the disease.Currently, most investigation is directed towards the amyloid-beta(Aβ) and tau pathologies, 相似文献
738.
Noelene K. Jeffers PhD CNM IBCLC Lucinda Canty PhD CNM FACNM Michelle Drew DNP MPH CNM FNP-C FACNM Nikia Grayson DNP MPH MA CNM FNP-C Jamarah Amani LM Ebony Marcelle DNP CNM FACNM Alexis Dunn Amore PhD CNM FACNM FAAN 《分娩》2023,50(2):267-272
Racial concordance has been identified as a potential strategy to improve the perinatal health of Black women and birthing people by mitigating implicit bias and improving mutual trust, healthy communication, and satisfaction. In a recent article published in BIRTH: Issues in Perinatal Care, Bogdan-Lovis et al. surveyed 200 Black women to determine whether they possessed a race and gender practitioner preference for their birth practitioner and examined whether race and gender concordance was associated with greater birth satisfaction and perceived respect, trust, practitioner competence, empathy, and use of inclusive communication. In this commentary, written by a group of Black midwives, we respond to the study and offer a vision for race-concordant care that encompasses cultural safety provided in a community-based setting. 相似文献
739.