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C Ferreli VI Sulica N Aste L Atzori M Pinna P Biggio 《Journal of the European Academy of Dermatology and Venereology》2003,17(4):443-445
BACKGROUND: Coma-induced bullae and sweat gland necrosis is a rare clinicopathological entity often associated with drug-induced coma. SUBJECT: We report a case with clinical and histopathologic findings characteristic of blisters and sweat gland necrosis occurring in a non-comatose patient. CONCLUSIONS: Skin blisters with underlying sweat gland necrosis is an entity previously reported to occur in comatose patients, our findings open new questions about the role of the drugs in the pathogenesis of those conditions. 相似文献
56.
Baginskaya NV Il'nitskaya SI Nikitenko EV Kaledin VI 《Bulletin of experimental biology and medicine》2007,144(6):821-824
o-Aminoazotoluene in noncarcinogenic doses promoted the development of liver tumors in female ICR mice induced by administration
of diethylnitrosamine during early ontogeny. Severe inflammatory infiltration and proliferation of oval cells were found in
liver tissue of these animals. The concentration of free thyroxin decreased in the blood. Our results supplement published
data that promoters of hepatocarcinogenesis inhibit thyroid function.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 12, pp. 672–675, December, 2007 相似文献
57.
Atrial Rate‐Responsive Pacing and Incidence of Sustained Atrial Arrhythmias in Patients with Implantable Cardioverter Defibrillators
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ADOLFO FONTENLA M.D. Ph.D. RAFAEL SALGUERO M.D. JOSE B. MARTINEZ‐FERRER M.D. ANIBAL RODRIGUEZ M.D. JAVIER ALZUETA M.D. Ph.D. ENRIQUE GARCIA M.D. NURIA BASTERRA M.D. RAFAEL ROMERO M.D. JOAQUIN FERNANDEZ DE LA CONCHA M.D. XAVIER VIÑOLAS M.D. Ph.D. JULIAN VILLACASTIN M.D. Ph.D. MARIA LOPEZ‐GIL M.D. FERNANDO ARRIBAS M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2016,39(6):548-556
58.
VICENTE BERTOMEU‐GONZÁLEZ M.D. Ph.D. JOSÉ MORENO‐ARRIBAS M.D. JESÚS CASTILLO‐CASTILLO M.D. JOSÉ MARTÍNEZ‐FERRER M.D. Ph.D. XAVIER VIÑOLAS M.D. Ph.D. ANÍBAL RODRÍGUEZ M.D. Ph.D. ERNESTO DÍAZ‐INFANTE M.D. Ph.D. IGNACIO FERNÁNDEZ‐LOZANO M.D. Ph.D. JAVIER ALZUETA M.D. Ph.D. ADOLFO FONTENLA M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2016,39(1):73-80
59.
A practical method for non-experts in assessing exposure to risk factors for work-related
musculoskeletal disorders (WMSDs) is presented. Evaluación del Riesgo Individual
(Individual Risk Assessment) (ERIN) is based on available ergonomic tools, epidemiological
evidence and the joint IEA-WHO project for developing WMSDs risk management in developing
countries. ERIN focuses primarily on the interaction of some physical workplace factors
but also includes the workers’ assessment. A scoring system has been proposed to indicate
the level of intervention required to reduce the risk of injury. A worksheet has also been
designed for increasing the usability of the method. Preliminary tests show that it is
easy and quick to use, but further work is needed to establish its reliability and
validity. The use of ERIN can contribute to the prevention of WMSDs in Cuba and other
developing countries. 相似文献
60.
OA Patutina NL Mironova EB Logashenko NA Popova VP Nikolin GV Vasil'ev VI Kaledin MA Zenkova VV Vlasov 《Bulletin of experimental biology and medicine》2012,152(3):348-352
RLS lymphosarcoma characterized by enhanced expression of mdr1a and mdr1b genes encoding P-glycoprotein is insensitive to low doses of cyclophosphamide, but is susceptible to its high doses approximating
the maximum tolerated doses. Induction of apoptotic death of RLS cells by high doses of cyclophosphamide was demonstrated
by cytofl uorometry and electrophoresis. Experiments on RLS40 tumor cells derived from RLS lymphosarcoma and characterized by more intensive expression of mdr1a/1b genes showed that the therapeutic effects of cyclophosphamide increased under conditions of simultaneous suppression of these
genes by specifi c small interfering RNA (siRNA). These fi ndings suggest that active cyclophosphamide metabolite can be a
substrate for P-glycoprotein. 相似文献