Analysis of Dietary Habits and Nutritional Status of Children with Down Syndrome in the Context of Lipid and Oxidative Stress Parameters

Introduction: The risk of obesity in children with Down syndrome is high. Undoubtedly, proper nutrition plays an important role in the prevention of excess body weight and is associated with a reduction of metabolic complications. The aim of the study was to assess the problem of disturbances in the nutritional status and eating habits of children with DS. Methods: A total of 39 patients were included in the study. The nutritional status was assessed by anthropometric tests and Dual X-ray Absorptiometry. Eating habits were assessed using the Child Eating Behavior Questionnaire and the Food Frequency Questionnaire. Blood samples were taken to determine the oxidative stress and lipid parameters. Results: Obesity was recognized in 15% of subjects and 23% were overweight. Children that were overweight were characterized by higher levels of triglycerides, atherogenic index of plasma, and apoA2 and apoE levels. Fat mass, fat mass/height² index, and visceral fat mass correlated with thiobarbituric acid reactive substances and advanced oxidative protein product level. The analysis of the Child Eating Behavior Questionnaire showed that children struggling with being overweight were more interested in food compared to those with normal body weight. A positive correlation was identified between waist circumference and food interest categories. Insufficient consumption of dairy products, vegetables, whole grain products, as well as fruits, seeds, nuts, and fatty fish was noted. Patients were less likely to consume products that are a good source of mono- and polyunsaturated fatty acids. Conclusions: In children with Down syndrome and obesity, disturbances in lipid and oxidative stress parameters are observed. Abnormal eating habits in all children with Down syndrome regardless of their nutritional status were noted. Proper nutritional education, nutritional control, and management of metabolic problems are essential in this group of patients.     

The Influence of Intensive Nutritional Education on the Iron Status in Infants

Iron is an essential nutrient for a child’s proper development at every growth stage. It is crucial for the production of red blood and muscle cells, DNA replication, and the development of the brain, nervous and immune systems. Iron deficiency is the most common micronutrient deficiency in children worldwide. Despite widespread access to nutritional information for children, parents continue to make many feeding mistakes. This study aimed to assess whether any nutritional intervention would affect the iron status in children. The parents of 203 children were randomly assigned to one of two groups: the study group received intensive mobile nutritional education for a year, while the control group received no intervention. Blood tests were performed on both groups at the beginning of the study and one year later. The educational intervention resulted in statistically significantly higher levels of RBC (red blood cells; p = 0.020), HGB (haemoglobin; p = 0.039), HCT (haematocrit; p = 0.036), MCV (mean cell volume; p = 0.018) parameters and iron dietary intake (p ≤ 0.001). Even a non-targeted dietary intervention improves the iron status in children. As iron management is insufficient in most children, an iron-targeted nutritional intervention appears necessary.     

Quality and Quantity Assessment of the Water Repellent Properties of Functional Clothing Materials after Washing

The aim of the research was to evaluate the changes in the surface properties of five functional clothing materials with water-repellent finishes (including PFC-free finish) after 1, 5, and 10 washes with three detergents. A new approach to the interpretation of the water-repellent properties of textile materials is presented, based on two techniques, i.e., the spray test method and contact angle measurements. The results showed that washing materials with hydrophobic finishes can cause significant changes in their properties, which are mainly dependent on the composition and structure of the material, as well as the type of hydrophobic finish. The PFC-free finish is the least resistant to washing. For all materials with PFC finishes, the water repellency depends on the fluorine content on the surface and fabric topography. It was also found that increasing washing frequency resulted in a gradual decrease in water repellency. The loss of water repellency below an acceptable level (Grade 3) occurred after the fifth washing for all materials. Significant differences in the interpretation of the results of the spray test and contact angle measurements were observed. Using these methods separately provides information on the changes in the surface properties of the tested materials; however, their parallel application allows for obtaining complementary data, which is important for the proper interpretation of results.     

Prognostic value of selected platelet parameters of patients operated for non-small cell lung cancer

BackgroundPlatelets play a vital role in the neoplastic process. Platelet parameters are hence an important source of information concerning ongoing neoplastic disease. The aim of the study is to assess the impact of selected platelet parameters on the survival of patients with non-small cell lung cancer (NSCLC).MethodsThe study included 532 (174 female and 358 male) patients aged 36–84 years (mean age 63.6 years) operated on due to NSCLC, staged IA–IIIA. Before the operation, all patients received a blood morphology test. The following parameters were subjected to statistical analysis: platelet count, mean platelet volume (MPV) parameter, platelet distribution width (PDW) parameter, platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation (SII) index. These findings were compared with the clinical data of the patients, and the probability of overall survival was analyzed.ResultsThe univariate analysis revealed a correspondence between PDW, MPV, PLR and SII index and patient survival. The multivariate analysis including patient clinical data found the following factors to have negative prognostic value for patients operated on due to NSCLC: male sex, advancement stage of neoplastic disease and Charlson Comorbidity Index (CCI) above 4, and PLR >144.ConclusionsPDW value, PLR and SII index are independent prognostic factors. In the multi-factor model, male sex, the advancement stage of the neoplastic disease, CCI above 4 and PLR lower than 144 had the greatest prognostic value.     

Assessment of Surface Treatment Degree of Steel Sheets in the Bonding Process

The aim of the paper is to determine the influence of the surface treatment on the adhesive properties of steel sheet surfaces and the strength of the adhesive joints of steel sheets. The paper also aims to assess the degree of steel sheets’ surface treatment in the bonding process. Due to the many methods of surface treatment and types of materials, the assessment of the surface treatment method is extremely important in adhesive processes. Two variants of the surface treatment were used: without a paint coating and with a paint coating, divided into two groups (without degreasing and with degreasing). Additionally, in the case of the analysis of the steel samples without the paint coating, mechanical treatment was applied. Two-component epoxy adhesive, prepared on the basis of bisphenol A and a polyamide curing agent, was used to prepare the single-lap adhesive joints of the steel sheets. The tests determined: (i) the adhesive properties of the steel sheets’ surface based on the measurement of the contact angle of polar and apolar liquids (including wettability, work of adhesion, and surface free energy), (ii) surface roughness parameters (PN EN ISO 4287), and (iii) mechanical properties (load capacity and shear strength) of the steel sheets’ adhesive joints (EN DIN 1465). Contact angle measurements of the steel sheet surfaces showed that the polar liquid better reflects the obtained strength results of the analyzed adhesive joints than the apolar liquid. Furthermore, better wettability of the surface of steel sheets with both polar and apolar liquids was obtained for samples whose surface was subjected to degreasing. It can also be concluded that the wettability of the surface can be used as one of the indicators of the degree of the surface treatment for the bonding process.     

The effect of levamisole on energy metabolism in Ehrlich ascites tumour cells in vitro

It has been found that levamisole, an anthelmintic drug, used also as an immunomodulator in human cancer therapy, is a strong inhibitor of tumour aerobic glycolysis. In vitro, in Ehrlich ascites tumour (EAT) cells and supernatants it diminishes glucose uptake and lactate formation. It does not, however, exert a similar inhibitory effect on glycolytic activity in normal liver and muscle supernatants. Metabolic and enzymatic studies have shown that levamisole directly inhibits tumour phosphofructokinase decreasing ATP, as well as 2-phosphoenolpyruvate and pyruvate as further glycolytic intermediates. L-Cysteine used for comparison also as another inhibitor of tumour aerobic glycolysis, decreasing glucose uptake and lactate formation and diminishing pyruvate and ATP levels, differs in the accompanying increase in 2-phosphoenolpyruvate concentration. This crossing-over in metabolite concentration, only seen in tumour material, points to tumour pyruvate kinase as an isoenzyme sensitive to cysteine inhibition. Direct enzymatic studies have confirmed this suggestion. Some similarities in the influence on the metabolism of both compounds studied have been discussed, as well as the role of the effects observed in understanding the mechanisms of levamisole action (also in worms).     

Assessment of the Impact of Ionizing Radiation Absorption on the Structural,Mechanical and Biophysical Properties of Textiles Used in Multilayer Space Suit

The article presents research on ergonomics, biophysical comfort and safety of protective clothing. The resistance of the structural, thermal and mechanical properties of five fabrics (CBXS400, GG200T, Twaron CT736, Dyneema HB26 and T1790C), differing in geometry and raw material composition used in space suits, to dangerous ionizing radiation (β and γ) occurring in space was tested. For both types of radiation, four identical one-time doses in the range of 25–100 kGy were used. The effect of the applied absorbed doses of β and γ radiation on the parameters of textiles influencing ergonomics and safety of the cosmonaut’s work was verified by structural tests (micro-computed tomography and optical microcopy), thermal resistance tests (sweating guarded-hotplate) and strength tests (tensile testing machine). Experimental studies of thermal properties are supplemented with heat transport simulations using the finite volume method performed with 3D models of real textiles. The greatest reduction of thermal resistance for Twaron CT736 (−0.0667 m²·°C·W⁻¹ for 100 kGy of β-radiation) and Dyneema HB26 (−0.0347 m²·°C·W⁻¹ for 50 kGy of β-radiation) is observed. Strength tests have shown that all tested textiles are resistant to both types of radiation. Three textiles were selected to create a three-layer assembly with potential application in a cosmonaut’s glove (Extravehicular Activity—EVA).     

Factors Affecting Dental Caries Experience in 12-Year-Olds,Based on Data from Two Polish Provinces

(1) Background: Dental caries is a chronic disease that affects a child’s dentition from the first stages of life. Several factors contribute to the development of the disease, including an improper diet. This cross-sectional study aimed to identify risk factors of dental caries in 12-year-old adolescents from Greater Poland and Lubusz Provinces (Poland). (2) Material and methods: The research was conducted in adolescents from five primary schools. A questionnaire consisted of close-ended questions on socioeconomic characteristics on family, diet, and oral hygiene habits. An assessment of the dentition was carried out in accordance with World Health Organization (WHO) recommendations. In addition to cavitated carious lesions, incipient caries lesions were noted according to the International Caries Detection and Assessment System, adapted for epidemiological studies (ICDASepiDMFt). (3) Results: The mean number of teeth with untreated caries; removed due to caries; and restored because of caries (DMFt) was 1.52 ± 1.90, while the ICDASepiDMFt index amounted to 2.64 ± 2.55, respectively. Children who did not brush every day had significantly higher odds of having ICDASepiDMFt > 0 than children brushing at least once daily (OR = 10.32, 95% CI = 1.36–78.32, p = 0.0240). Adolescents who drank sweet carbonated drinks every day had significantly higher ICDASepiDMTt than children who drank sweet carbonated drinks less frequently (p = 0.0477). (4) Conclusions: The research revealed that dental caries indices of 12-year-old adolescents from Greater Poland and Lubusz Provinces depend mainly on oral hygiene behaviors. The only significant nutritional factor that differentiated the caries intensity was the daily consumption of sweet carbonated drinks.     

Zeolite-Supported Aggregate as Potential Antimicrobial Agents in Gypsum Composites

Relatively easy treatment of glass aggregates can lead to the formation of a highly porous zeolite aggregate. This study focuses on the possibility of using such an aggregate as an active additive to a gypsum binder. The physical properties of hardened gypsum composites with zeolite fillers doped with various metal ions (Ni²⁺, Cu²⁺, and Zn²⁺) have been compared. In addition to studies of the basic physical properties of the composites, structural and microstructural studies as well as antimicrobial tests were performed. It was found that the parameters of the composites with the addition of various ions do not differ significantly from the reference but modifies the microstructure. Among other things, the ions analyzed reduce the microporosity of gypsum composites. Using all aggregates, a product with adequate strength (above 2 MPa) and thermal conductivity (about 0.35 W/m·K) appropriate for typical lightweight gypsum composites can be obtained. The bacteriostatic effect of formulations with copper and zinc against Escherichia coli and with copper against Staphylococcus aureus was found.     

ARFID—Strategies for Dietary Management in Children

Avoidant/Restrictive Food Intake Disorder (ARFID) is a relatively new disease entity in DSM-5 and ICD-11. This disorder continues to pose a diagnostic and therapeutic challenge for many professionals. This disorder can affect people of all ages. The most characteristic pattern is considered to be a lack of interest in eating or avoidance of food intake, which may result in nutritional deficiencies, weight loss or lack of expected weight gain, dependence on enteral feeding or dietary supplements, and impaired psychosocial functioning. This disorder cannot be explained by a current medical condition or co-occurring other psychiatric disorders, but if ARFID co-occurs with another disorder or illness, it necessarily requires extended diagnosis. Its treatment depends on the severity of the nutritional problem and may include hospitalization with multispecialty care (pediatrician, nutritionist, psychologist, psychiatrist, neurologist). The nutritional management strategy may include, inter alia, the use of Food Chaining, and should in the initial stage of therapy be based on products considered “safe” in the patient’s assessment. The role of the dietitian in the management of a patient with ARFID is to monitor weight and height and nutritional status and analyze the foods that should be introduced into the food chain first.