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81.
82.
J E Mokry 《Bulletin of the World Health Organization》1978,56(3):455-456
Cnephia mutata was successfully induced to complete two entire generations in the laboratory. Owing to its triploid condition, this simuliid is parthenogenetic and mature eggs may be dissected from the ovaries, thus eliminating both mating and oviposition. C. mutata in Newfoundland is also autogenous, making blood-feeding unnecessary. Progress towards colonization of this species is reviewed. 相似文献
83.
84.
Bernard Weiss Juraj Ferin William Merigan Sander Stern Christopher Cox 《Toxicology and applied pharmacology》1981,58(2):244-251
Ozone exposure may induce extrapulmonary consequences, such as reductions in the spontaneous activity of rodents, or complaints in humans of lethargy, headache, chest discomfort, and other subjective symptoms. Further evidence of behavioral disruption was provided by this experiment. Twelve rats were trained to perform a bar-pressing response maintained by food reward. Food pellets were delivered according to a fixed interval 5-min reinforcement schedule. Exposures encompassed a range of concentrations from 0.1 to 2.0 ppm. A single exposure lasted 6 hr, and successive exposures were separated by at least 6 days. Compared to performance under control conditions (ambient air), response rates fell linearly from 0.1 to 1.4 ppm. During individual 6-hr exposures, the rates declined from the beginning to the end of the session. These results, given the sedentary nature of the task, reflect reduced inclination rather than impaired physiological capacity to respond. 相似文献
85.
Various compounds known to cause DNA damage (hydrogen peroxide, visible light-excited methylene blue, N-nitrosomorpholine and benzo[a]pyrene) were tested with different primary rat cells (lymphocytes, testicular cells, type II pneumocytes and hepatocytes) to determine the range of induced DNA damage applying the comet assay. A dose-dependent increase of DNA breaks was observed after treatment with hydrogen peroxide in all cell types studied. The most prominent effect was observed in lymphocytes, whereas only a slight increase of DNA breaks was observed in hepatocytes. Visible light-excited methylene blue caused significant oxidative DNA damage, which did not significantly differ between the cell types used with the exception of hepatocytes, for which a lower level of DNA damage was observed. N-Nitrosomorpholine and benzo[a]pyrene induced a moderate but significant increase of DNA strand breaks in pneumocytes and hepatocytes while in lymphocytes no effect was observed. Our results clearly demonstrate that due to their differential function which is also expressed by the level of drug metabolizing and/or antioxidant enzymes, freshly isolated rat cells (lymphocytes, testicular cells, type II pneumocytes and hepatocytes) respond differently to the exposure to genotoxic agents as detected by comet assay. 相似文献
86.
87.
88.
Shi CS Shenderov K Huang NN Kabat J Abu-Asab M Fitzgerald KA Sher A Kehrl JH 《Nature immunology》2012,13(3):255-263
Autophagosomes delivers cytoplasmic constituents to lysosomes for degradation, whereas inflammasomes are molecular platforms activated by infection or stress that regulate the activity of caspase-1 and the maturation of interleukin 1β (IL-1β) and IL-18. Here we show that the induction of AIM2 or NLRP3 inflammasomes in macrophages triggered activation of the G protein RalB and autophagosome formation. The induction of autophagy did not depend on the adaptor ASC or capase-1 but was dependent on the presence of the inflammasome sensor. Blocking autophagy potentiated inflammasome activity, whereas stimulating autophagy limited it. Assembled inflammasomes underwent ubiquitination and recruited the autophagic adaptor p62, which assisted their delivery to autophagosomes. Our data indicate that autophagy accompanies inflammasome activation to temper inflammation by eliminating active inflammasomes. 相似文献
89.
Rievaj J Davidson C Nadeem A Hollenberg M Duszyk M Vliagoftis H 《Pflügers Archiv : European journal of physiology》2012,463(3):497-509
Protease-activated receptor 2 (PAR-2) is a G protein-coupled receptor possibly involved in the pathogenesis of asthma. PAR-2
also modulates ion transport in cultured epithelial cells, but these effects in native airways are controversial. The influence
of allergic inflammation on PAR-2-induced changes in ion transport has received little attention. Here, we studied immediate
changes in transepithelial short circuit current (I
sc) induced by PAR-2 activation in the tracheas of naive and allergic mice. Activation of PAR-2 with an apically added activation
peptide (AP) induced a small increase in I
sc, while a much larger increase was observed following basolateral AP addition. In ovalbumin-sensitized and -challenged animals
used as a model of allergic airway inflammation, the effect of basolateral AP addition was enhanced. Responses to basolateral
AP in both naive and allergic mice were not decreased by blocking sodium absorption with amiloride or CFTR function with CFTRinh172 but were reduced by the cyclooxygenase inhibitor indomethacin and largely blocked (>80%) by niflumic acid, a calcium-activated
chloride channels’ (CaCC) blocker. Allergic mice also showed an enhanced response to ATP and thapsigargin. There was no change
in mRNA expression of Par-2 or of the chloride channels Ano1 (Tmem16a) and Bestrophin 2 in tracheas from allergic mice, while
mRNA levels of Bestrophin 1 were increased. In conclusion, basolateral PAR-2 activation in the mouse airways led to increased
anion secretion through apical CaCC, which was more pronounced in allergic animals. This could be a protective mechanism aimed
at clearing allergens and defending against mucus plugging. 相似文献
90.
Juraj Majtán Jaroslav ?erny Alena Ofúkaná Peter Taká? Milan Kozánek 《Asian Pacific Journal of Tropical Biomedicine》2012,2(2):85-87