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排序方式: 共有4665条查询结果,搜索用时 15 毫秒
31.
Kobayashi Mana Kageyama Yutaro Ando Takashi Sakamoto Junko Kimura Shohji 《Clinical and experimental nephrology》2021,25(8):854-864
Clinical and Experimental Nephrology - Rituximab is conditionally approved in Japan for use in patients with refractory nephrotic syndrome. To meet the conditions of approval, an all-case... 相似文献
32.
1-Methyl-tetrahydro--carboline-3-carboxylic acid (MTCA) may cause eosinophilia-myalgia syndrome (EMS) associated with ingestion ofl-tryptophan. The distribution and excretion of MTCA were studied in rats which had received perorally a single 1.6 mg/kg dose of MTCA. MTCA concentrations in blood, kidney, liver, brain, heart, spleen, lung and gastrocnemius muscle were measured by HPLC combined with fluorometric detection. The concentration of MTCA in each organ reached a maximum at 1 h and then gradually declined. However, a significant level of MTCA still remained at 5 h, when 52% of ingested MTCA remained in the contents of the large intestine. Twenty-nine percent of the ingested MTCA was excreted in urine over the course of 24 h. A higher dose (10 mg/kg) of MTCA resulted in significant elevations in the concentrations and amounts of MTCA in the various organs. In addition, chronic treatment with a 10 mg/kg dose of MTCA for 6 weeks further increased the concentrations and amounts of MTCA in each organ. However, no histological changes were observed in any of the organs after chronic treatment. This is the first report which demonstrates accumulation of MTCA in the blood and various organs, including muscle, of rats. 相似文献
33.
34.
Funato Kouichi Yamashita Chikamasa Kamada Junko Tominaga Sachiko Kiwada Hiroshi 《Pharmaceutical research》1994,11(3):372-376
Several plasma components, such as complement (C) components, play a role in the clearance of liposomes from the circulation. The interactions between liposomes and the C system were investigated in this study. Multilamellar vesicle (MLV) liposomes, which were damaged by activation of the complement, became susceptible depending on the density of cetylmannoside (Man) on the liposome membrane, and activation proceeded through the alternative C pathway as observed for liposomes without Man (PC-MLV) (K. Funato et al, Biochim. Biophys. Acta 1103:198–204, 1992). In addition, the capacity of Man-modified liposomes (Man-MLV) to activate the alternative C pathway was abolished by preadsorption of plasma with Man-MLV but not with PC-MLV. The results suggest that a specific plasma factor adsorbed with Man-MLV was responsible for the augmentation of the C activation and, further, that the rapid clearance of Man-MLV from the circulation is caused by both enhanced C-mediated liposome permeability and enhanced C-mediated phagocytosis of liposomes. 相似文献
35.
A case of a melanotic schwannoma presenting as a soft tissue mass of the abductors of the hip is reported. The radiographic findings suggested myositis ossificans, but several subtle findings raised the concern for something else. A bilobed appearance, lack of classic zoning pattern of the ossification, and atypical pain pattern should alert the physician. Biopsy should be considered if the radiographic and clinical presentations are not classic for myositis ossificans. 相似文献
36.
Junko Miyamoto Hiroshi Asanuma Hideo Nakai Tomonobu Hasegawa Hajime Nawata Yukihiro Hasegawa 《Clinical Pediatric Endocrinology》2006,15(4):151-162
The prevalence of abnormalities in androgen receptor gene (AR) among patients with
ambiguous genitalia is unknown. Moreover, endocrinological data from prepubertal patients
with AR mutation are very limited. Thus, the aim of this study was to examine the
prevalence of abnormalities in AR among patients with both ambiguous genitalia, which was
defined as a combination of two or more genital abnormalities (i.e. hypospadias,
microphallus (penile length < 25 mm), hypoplastic scrotum, bifid scrotum, undescended
testis) in this study, and normal to elevated T levels. We also compared the
endocrinological data of prepubertal patients with AR mutation and ambiguous genitalia
with that of those without the AR mutation. We screened 26 Japanese prepubertal 46,XY
patients (five from three families were included) with both ambiguous genitalia and normal
to elevated T levels. Mutations in AR were found in three (two of the three were related).
Among the 23 patients without mutation in AR, the steroid 5-alpha-reductase 2 gene
(SRD5A2) was also examined in eight patients with elevated T/dehydrotestosterone ratio
after the hCG (>10) or with undervirilized family members. No mutation in SRD5A2 was
found. Characteristics of the three patients with mutation in AR were compared with the 23
patients without mutation. In two patients, basal T levels (0.3, 0.2 ng/ml) and peak T
levels after the hCG tests (8.3, 8.5 ng/ml) tended to be higher, and the peak LH/ peak FSH
ratios after the GnRH tests (4.6, 4.0) were higher than in patients without mutation, at
the ages of 1 yr and 9 mo and 3 yr and 8 mo, respectively. In conclusion, an abnormality
in either AR or SRD5A2 was not common among patients with ambiguous genitalia and normal
testosterone secretion. Elevated peak LH/peak FSH ratio (≥4) after the GnRH test in
addition to detectable basal T levels and elevated peak T levels after the hCG test may
infer AR abnormality in prepubertal patients with ambiguous genitalia at the age of one
and over, although further study is needed, because our data were limited. 相似文献
37.
38.
Koji Nakajima Hirohito Kubota Itaru Kato Kiyotaka Isobe Hiroo Ueno Kagehiro Kozuki Kuniaki Tanaka Naoko Kawabata Takashi Mikami Kosuke Tamefusa Ritsuo Nishiuchi Satoshi Saida Katsutsugu Umeda Hidefumi Hiramatsu Souichi Adachi Junko Takita 《Cancer science》2022,113(7):2472
Lineage switch is a rare event at leukemic relapse. While mostly known to occur in KMT2A‐rearranged infant leukemia, the underlying mechanism is yet to be depicted. This case report describes a female infant who achieved remission of KMT2A‐MLLT3‐rearranged acute monocytic leukemia, but 6 months thereafter, relapsed as KMT2A‐MLLT3‐rearranged acute lymphocytic leukemia. Whole exome sequencing of the bone marrow obtained pre‐post lineage switch revealed two somatic mutations of PAX5 in the relapse sample. These two PAX5 alterations were suggested to be loss of function, thus to have played the driver role in the lineage switch from acute monocytic leukemia to acute lymphocytic leukemia. 相似文献
39.
Therapeutic advances in BIG3‐PHB2 inhibition targeting the crosstalk between estrogen and growth factors in breast cancer 下载免费PDF全文
Tetsuro Yoshimaru Masato Komatsu Yasuo Miyoshi Junko Honda Mitsunori Sasa Toyomasa Katagiri 《Cancer science》2015,106(5):550-558
Our previous studies demonstrated that specific inhibition of the BIG3‐PHB2 complex, which is a critical modulator in estrogen (E2) signaling, using ERAP, a dominant negative peptide inhibitor, leads to suppression of E2‐dependent estrogen receptor (ER) alpha activation through the reactivation of the tumor suppressive activity of PHB2. Here, we report that ERAP has significant suppressive effects against synergistic activation caused by the crosstalk between E2 and growth factors associated with intrinsic or acquired resistance to anti‐estrogen tamoxifen in breast cancer cells. Intrinsic PHB2 released from BIG3 by ERAP effectively disrupted each interaction of membrane‐associated ERα and insulin‐like growth factor 1 receptor beta (IGF‐1Rβ), EGFR, PI3K or human epidermal growth factor 2 (HER2) in the presence of E2 and the growth factors IGF or EGF, followed by inhibited the activation of IGF‐1Rβ, EGFR or HER2, and reduced Akt, MAPK and ERα phosphorylation levels, resulting in significant suppression of proliferation of ERα‐positive breast cancer cells in vitro and in vivo. More importantly, combined treatment with ERAP and tamoxifen led to a synergistic suppression of signaling that was activated by crosstalk between E2 and growth factors or HER2 amplification. Taken together, our findings suggest that the specific inhibition of BIG3‐PHB2 is a novel potential therapeutic approach for the treatment of tamoxifen‐resistant breast cancers activated by the crosstalk between E2 and growth factor signaling, especially in premenopausal women. 相似文献
40.
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation 下载免费PDF全文