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排序方式: 共有1299条查询结果,搜索用时 10 毫秒
11.
Trukeschitz Birgit Hajji Assma Batchelder Laurie Saloniki Eirini Linnosmaa Ismo Malley Juliette 《Quality of life research》2021,30(7):1975-1984
Quality of Life Research - The Adult Social Care Outcomes Toolkit for informal carers (ASCOT-Carer) can be used to assess long-term care-related quality of life (LTC-QoL) of adult informal carers... 相似文献
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Trukeschitz Birgit Hajji Assma Litschauer Judith Malley Juliette Schoch Adiam Rand Stacey Linnosmaa Ismo Forder Julien 《Quality of life research》2021,30(3):905-920
Quality of Life Research - The Adult Social Care Outcomes Toolkit for Carers (ASCOT-Carer), developed in England, measures the effects of long-term care (LTC) services and carer support on informal... 相似文献
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Milena Kohn Marc Delord Maureen Chbat Amina Guemriche Fatiha Merabet Anne-Laure Roupie Naelle Lombion Hassan Farhat Thomas Longval Aurlie Cabannes-Hamy Juliette Lambert Stphanie Marque-Juillet Victoria Raggueneau Jennifer Osman Marc Spentchian Sophie Rigaudeau Philippe Rousselot Caroline Besson 《Haematologica》2022,107(6):1454
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Dimitri Gambachidze Chloë Lefvre Emmanuel Chartier‐Kastler Marie‐Aime Perrouin Verbe Jacques Kerdraon Guy Egon Alexia Even Pierre Denys Evelyne Castel‐Lacanal Xavier Gam Alain Ruffion Juliette Hascoet Benoit Peyronnet Haude Chaussard Kvin Lo Verde Gilles Karsenty Vronique Ph 《Neurourology and urodynamics》2019,38(6):1713-1720
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CD95 engagement induces disseminated endothelial cell apoptosis in vivo: immunopathologic implications 总被引:6,自引:3,他引:6
Janin A Deschaumes C Daneshpouy M Estaquier J Micic-Polianski J Rajagopalan-Levasseur P Akarid K Mounier N Gluckman E Socié G Ameisen JC 《Blood》2002,99(8):2940-2947
Fas (CD95) is a death receptor involved in apoptosis induction on engagement by Fas ligand (CD95L). Although CD95L-mediated apoptosis has been proposed as a pathogenic mechanism in a wide range of diseases, including graft-versus-host disease, systemic CD95 engagement in mice by agonistic CD95-specific antibodies or by soluble multimeric CD95L (smCD95L), though lethal, has been reported to cause apoptosis only in a limited range of cell types, that is, hepatocytes, hepatic sinusoidal endothelial cells, and lymphocytes. Another member of the tumor necrosis factor (TNF)/CD95L family, TNF-alpha, induces disseminated vascular endothelial cell apoptosis, which precedes apoptosis of other cell types and lethal multiorgan failure. Here we show that systemic CD95 engagement in vivo by agonistic CD95-specific antibody or smCD95L causes rapid, extensive, and disseminated endothelial cell apoptosis throughout the body, by a mechanism that does not depend on TNF-alpha. Disseminated endothelial cell apoptosis was also the first detectable lesion in a murine model of acute tissue damage induced by systemic transfer of allogeneic lymphocytes and did not occur when allogeneic lymphocytes were from CD95L-defective mice. Both vascular and additional tissue lesions induced by agonistic CD95-specific antibody, smCD95L, or allogeneic lymphocytes were prevented by treatment with an inhibitor of caspase-8, the upstream caspase coupled to CD95 death signaling. Vascular lesions are likely to play an important role in the pathogenesis of allogeneic immune responses and of other diseases involving circulating CD95L-expressing cells or smCD95L, and the prevention of CD95-mediated death signaling in endothelial cells may have therapeutic implications in these diseases. 相似文献
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