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21.
22.
The pharmacokinetics of an intravenous immunoglobulin (IVIG), Gammagard (Baxter Healthcare Corp., Glendale, CA), were measured in 31 cytomegalovirus (CMV) antibody negative bone marrow transplant (BMT) patients as part of a multicenter efficacy trial of 2 weekly dose regimens. Since all patients lacked antibody to CMV and received only screened CMV negative blood products, the half-life of the exogenous CMV antibody could be measured with an ELISA assay. The CMV antibody titer was related to the immunoglobulin concentration using a standard curve. Compared with the 22-day half-life in normal subjects, the half-life in BMT patients was approximately 6 days for either the 250 mg/kg or 500 mg/kg dose regimen. The half-life did not change over the subsequent 3 weekly doses. Peak concentrations were 3.5 +/- 1.4 and 2.6 +/- 0.7 mg/mL of IVIG in week 1 as well as 5.5 +/- 2.6 and 3.4 +/- 1.2 mg/mL in week 3 after the 250 mg/kg and 500 mg/kg, respectively. Total body clearance of IVIG was 0.61 and 0.46 mL/kg/hr for the 500 mg/kg and 250 mg/kg, respectively. 相似文献
23.
24.
Ehab Farag Maged Argalious Samer Narouze Glenn E. DeBoer Julie Tome 《Journal canadien d'anesthésie》2002,49(9):958-962
PURPOSE: To present the anesthetic management for the correction of a ventricular septal defect (VSD) in a patient with multiple acyl CoA dehydrogenase deficiency (glutaric aciduria type II; GAII). A review of the literature about anesthetic management of patients with mitochondrial diseases undergoing cardiopulmonary bypass (CPB) is also included. Clinical features: An 11-yr-old girl with GAII manifested as severe hypoglycemia since she was a newborn and generalized muscle weakness. She underwent open-heart surgery for VSD correction with CPB. The anesthetic management avoided inhalational anesthetics, maintained the blood sugar within normal limits and continued normothermia during CPB in order to avoid the stress of hypothermia for her abnormal mitochondria. The patient tolerated the procedure well and experienced a good recovery. CONCLUSION: The anesthetic management of patients with any mitochondrial disease requires normoglycemia, normothermia and the avoidance of metabolic stress in order to preserve energy production by the diseased mitochondria. 相似文献
25.
Efficacy of intensive multitherapy for patients with type 2 diabetes mellitus: a randomized controlled trial 总被引:1,自引:1,他引:0
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26.
Zoï Kapoula Maria Pia Bucci Frederic Jurion Julie Ayoun Farzaneh Afkhami Dominique Brémond-Gignac 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2006,245(7):931-936
Aim There is a controversy as to whether dyslexic children present visuo-motor disabilities such as vergence and accommodative
problems assessed with orthoptic tests. The purpose of this study is to re-examine this issue in a large population of children.
Methods Extensive orthoptic evaluation was made in 57 dyslexic and 46 non-dyslexic (“normal”) age-matched children. Convergence and
divergence capacities were evaluated at two distances (30 cm and 400 cm).
Results Binocular vision measured with stereo-acuity tests was normal in dyslexics. In contrast, the near point of convergence was
significantly more remote in dyslexics; most importantly, divergence at both far and near distance was significantly more
reduced in dyslexics (median value 4 pD and 10 pD, respectively, at far and near) than in “normals” (median value 6 pD and
12 pD, at far and near).
Conclusion The existence of the divergence deficit at far distance indicates the presence of deficit of divergence per se, independently
from convergence and accommodation relaxation. This result is novel and corroborated by physiological studies indicating distinct
control of convergence and divergence, both at the cortical and subcortical premotor level. We conclude that vergence deficits
are frequently present in dyslexics, and that dyslexics should be re-educated; training should address distinctively convergence
and divergence subsystems. 相似文献
27.
Julie M Aultman 《Medical education》2009,43(11):1107-1107
28.
D J Brooks J S Gibbs P Sharp S Herold D R Turton S K Luthra E M Kohner S R Bloom T Jones 《Journal of cerebral blood flow and metabolism》1986,6(2):240-244
Regional cerebral [11C]3-O-methyl-D-glucose ([11C]MeG) uptake kinetics have been measured in five insulin-dependent diabetic patients and four normal controls using positron emission tomography (PET). Concomitant measurement of regional cerebral blood volume and CBF enabled corrections for the presence of intravascular [11C]MeG signal in cerebral regions of interest to be carried out, and regional cerebral [11C]MeG unidirectional extraction fractions to be computed. Four of the five diabetic subjects were studied with their fasting plasma glucose level clamped at a normoglycaemic level (4 mM), and four were studied at hyperglycaemic plasma glucose levels (mean 13 mM). The four diabetic subjects whose fasting plasma glucose levels were clamped at a normoglycaemic level of 4 mM had mean fasting whole-brain, cortical, and white matter [11C]MeG extraction fractions of 15, 15, and 16%, respectively, values similar to those found for the four normal controls (whole brain, 14%; cortex, 13%; white matter, 17%). Mean regional cerebral [11C]MeG extraction fractions were significantly reduced in diabetic subjects during hyperglycaemia whether their plasma insulin levels were undetectable or whether they were raised by continuous intravenous insulin infusion. Such a reduction in [11C]MeG extraction under hyperglycaemic conditions can be explained entirely in terms of increased competition between [11C]MeG and D-glucose for the passive facilitated transport carrier system for hexoses across the blood-brain barrier (BBB). It is concluded that the number and affinity of D-glucose carriers present in the BBB are within normal limits in treated insulin-dependent diabetic subjects. In addition, insulin appears to have no effect on the transport of D-glucose across the BBB. 相似文献
29.
N G Crisp C B Ijsselmuiden R De Swardt M M Steyn D M Gibbs E T Tshabalala 《Suid-Afrikaanse tydskrif vir geneeskunde》1987,72(5):345-348
Following the outbreak of poliomyelitis in Gazankulu in 1982, the immunisation services in Gazankulu were thoroughly examined. As a result of this, a comprehensive immunisation policy for Gazankulu was accepted in November 1986. The broad aim of the policy is to provide effective immunisation to all Gazankulu residents against tuberculosis, diphtheria, pertussis, tetanus, poliomyelitis and measles. A specific objective is that by the end of 1987, 85% of under-5s should have been vaccinated against these six diseases and by the end of 1990 this percentage should be 97%. The detailed strategies to reach these objectives are highlighted. Within the framework of the objectives, the policy allows different areas to formulate individual strategies. Programme monitoring and community involvement are two crucial aspects of the policy and these are discussed in detail. The early successes and difficulities in implementing this policy are discussed. 相似文献
30.
Julie A Clennon Aniset Kamanga Mulenga Musapa Clive Shiff Gregory E Glass 《International journal of health geographics》2010,9(1):58