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71.
目的 建立高效液相色谱法测定蜂丁麻滴眼剂中盐酸麻黄碱含量的方法。 方法 采用YWGC18分析色谱柱 ( 4 6mmID× 2 5 0mm ,粒径 10 μm) ,C18保护柱 ( 4 6mmID× 5mm ,粒径 10 μm) ,流动相 10 %乙腈 ( 0 5 %三乙胺 ,磷酸调pH3 0 ) ,流速 1 0ml/min ,检测波长 2 0 8nm ,测定对照品和样品色谱图 ,记录盐酸麻黄碱色谱峰面积 ,计算其含量。 结果 盐酸麻黄碱的理论板数为 10 0 0 0。回归方程 :y =90 5 878 16 15 1738x ,r=0 9999,线性范围 0 4 0 32~ 1 6 13μg。平均回收率为 99 2 % (RSD1 6 % )。 结论 该法操作简便 ,结果准确 ,可用于测定蜂丁麻滴眼剂中盐酸麻黄碱的含量 相似文献
72.
MR扩散加权成像鉴别脑结核瘤及高级星形细胞瘤和脑转移瘤的价值 总被引:3,自引:0,他引:3
目的探讨MR扩散加权成像(DWI)在脑结核瘤、高级星形细胞瘤和脑转移瘤鉴别诊断中的价值。方法14例脑结核瘤、15例脑高级星形细胞瘤和21例脑转移瘤患者,在术前或接受治疗前行常规MRI和DWI。测量并计算3种疾病瘤体、瘤周围水肿带的平均表观扩散系数(ADC)值和病灶与对侧相应部位正常脑白质区ADC值的比值(rADC值)。结果脑结核瘤瘤体平均ADC值和rADC值分别为(1.2±0.2)×10^-3mm^2·s^-1和1.6±0.3,高级星形细胞瘤瘤体平均ADC值和rADC值分别为(0.8±0.1)×10^-3mm^2·s^-1和1.1±0.1,转移瘤瘤体平均ADC值和rADC值分别为(0.8±0.1)×10^-3mm^2·s^-1和1.0±0.2。3种疾病瘤体平均ADC值(F=33.57,P〈0.01)之间和rADC值(F=33.27,P〈0.01)之间差异均有统计学意义。脑结核瘤瘤周水肿带平均ADC值和rADC值分别为(1.8±0.1)×10^-3mm^2·s^-1和2.5±0.2,脑高级星形细胞瘤瘤周水肿带平均ADC值和rADC值分别为(1.4±0.2)×10^-3mm^2·s^-1和1.8±0.3,脑转移瘤瘤周水肿带平均ADC值和rADC值分别为(1.9±0.2)×10^-3mm^2·s^-1和2.3±0.5。3种疾病瘤周围水肿带平均ADC值(F=23.17,P〈0.01)之间和rADC值(F=5.94,P〈0.01)之间差异均有统计学意义。结论结合MRI、DWI检测方法,根据病灶瘤体和瘤周水肿带的ADC和rADC值可帮助鉴别脑结核瘤、脑高级星形细胞瘤和脑转移瘤。 相似文献
73.
Alfredo Avellaneda Fernández álvaro Pérez Martín Maravillas Izquierdo Martínez Mar Arruti Bustillo Francisco Javier Barbado Hernández Javier de la Cruz Labrado Rafael Díaz-Delgado Pe?as Eduardo Gutiérrez Rivas Cecilia Palacín Delgado José Ramón Ramón Giménez Javier Rivera Redondo 《Atencion primaria / Sociedad Espa?ola de Medicina de Familia y Comunitaria》2009,41(10):e1-e5
74.
75.
Jonathan D Schiff Michelle L Ramírez Natan Bar-Chama 《Endocrinology & Metabolism Clinics of North America》2007,36(2):313-331
Male infertility is the result of a variety of highly treatable conditions. The critical step in treating male infertility is to evaluate properly every male partner of an infertile couple and to generate the proper treatment strategy. There are many medical and surgical options that can help most couples overcome male factor infertility. Male infertility can most easily be broken down into problems of sperm production (testicular dysfunction) and problems of sperm transport (obstruction). When applicable, medical therapies are used as an initial strategy to improve sperm production or as a preliminary therapy to boost production transiently in anticipation of a surgical sperm retrieval attempt. A range of surgical options is available to correct varicoceles, reconstruct the obstructed system, or retrieve sperm for assisted reproduction. 相似文献
76.
对58例下肢静脉曲张患者行大隐静脉高位结扎术联合腔内激光治疗,结果治疗效果满意,术后平均住院5.0d,未发生并发症,随访2年无复发。提出加强术前、术后护理及康复指导,对帮助患者顺利进行手术,促进康复,预防复发有重要意义。 相似文献
77.
Mònica Gratacòs Juan R González Josep M Mercader Rafael de Cid Mikel Urretavizcaya Xavier Estivill 《Neuropsychopharmacology》2007,61(7):911-922
BACKGROUND: There is an increasing recognition that the pathophysiology of mental disorders could be the result of deregulation of synaptic plasticity with alterations of neurotrophins. The valine (Val)66-to-methionine (Met) variant, located in the pro brain-derived neurotrophic factor (BDNF) sequence, has been extensively studied through linkage and association approaches in several psychiatric disorders. METHODS: We performed a meta-analysis restricted to individual case-control studies in different categories of mental disorders and BDNF Val66Met polymorphism. We included data from 39 case-control studies encompassing psychiatric phenotypes: eating disorders, substance-related disorders, mood disorders, and schizophrenia, among others. RESULTS: The association of Val66Met was confined to three diagnoses: substance-related disorders, eating disorders, and schizophrenia. The Val/Met and the Met/Met genotypes increase the risk for eating disorders up to 33%, while these same genotypes confer a 21% protective effect in substance-related disorders. The homozygous carriers Met/Met showed a 19% increased risk of schizophrenia with respect to the heterozygous state. CONCLUSIONS: The study confirms the association of Val66Met to substance-related disorders, eating disorders, and schizophrenia. It remains to be determined if other variants in tight linkage disequilibrium with Val66Met could configure an extended functional haplotype that would explain observed discrepancies in risk estimations across studies. 相似文献
78.
Stephen H Berns Ethan A Halm Hugh A Sampson Scott H Sicherer Paula J Busse Juan P Wisnivesky 《The Journal of asthma》2007,44(5):377-381
BACKGROUND: The objective of this study was to evaluate the relationship between food allergy and asthma morbidity in adults. METHODS: We interviewed a cohort of persistent asthmatics from an inner-city clinic. Allergies to food were assessed by patient report of convincing symptoms of acute allergic reactions. Outcome variables included health resource utilization and medication use. RESULTS: The prevalence of allergy to fish, peanut, tree-nut, shellfish, and seed allergies were 3%, 3%, 3%, 13%, and 1%. Patients with allergies to > 1 food had increased asthma hospitalizations, ED visits, and use of oral steroids (p < 0.05 for all comparisons). Specifically, allergy to fish was associated with a greater risk of health resource utilization and increased frequency of oral steroid use (p < or = 0.03 for all comparisons). CONCLUSIONS: Self-reported allergy to foods was associated with worse outcomes, suggesting that food allergy may be a risk factor for increased asthma morbidity in adults. 相似文献
79.
José M Quintana Inmaculada Arostegui Antonio Escobar Iratxe Lafuente Juan C Arenaza Isidoro Garcia Urko Aguirre 《BMC musculoskeletal disorders》2007,8(1):84
Background
To develop a sensitive and specific screening tool for knee and hip osteoarthritis in the general population of elderly people. 相似文献80.
Michael C. Cheung Eduardo A. Perez Manuel A. Molina Xiaoling Jin Juan C. Gutierrez Dido Franceschi Alan S. Livingstone Leonidas G. Koniaris 《Journal of gastrointestinal surgery》2008,12(4):731-738
Objective The objective of the study was to determine the outcomes for primary gastrointestinal melanomas (PGIM).
Material and methods The Surveillance, Epidemiology, and End Results database (1973–2004) was queried.
Results Overall, 659 cases of PGIM were identified. The annual incidence of PGIM was approximately 0.47 cases per million in 2000.
Overall median survival time was 17 months. Tumors were identified in the oral–nasopharynx (32.8%), anal canal (31.4%), rectum
(22.2%), esophagus (5.9%), stomach (2.7%), small bowel (2.3%), gallbladder (1.4%), and large bowel (0.9%). Univariate analysis
demonstrated age, tumor location, stage, surgery, and lymph node status were significant predictors of improved survival.
MST has not been reached for tumors located in the large bowel, while tumors located in the stomach demonstrated the shortest
median survival (5 months). Improvement in MST was observed for those patients undergoing surgical resection. The presence
of lymph node involvement conferred a poorer prognosis. Multivariate analysis of the cohort identified that location, advanced
tumor stage, failure to undertake surgical resection, positive lymph node status, and age were all independent predictors
of poorer outcome.
Conclusion PGIM occurs most often in the oral–nasopharynx and anal canal. Surgical extirpation is the only identifiable treatment modality
that significantly improves survival. 相似文献