全文获取类型
收费全文 | 5077篇 |
免费 | 282篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 59篇 |
妇产科学 | 102篇 |
基础医学 | 601篇 |
口腔科学 | 54篇 |
临床医学 | 441篇 |
内科学 | 1658篇 |
皮肤病学 | 124篇 |
神经病学 | 544篇 |
特种医学 | 87篇 |
外科学 | 554篇 |
综合类 | 11篇 |
一般理论 | 4篇 |
预防医学 | 462篇 |
眼科学 | 31篇 |
药学 | 241篇 |
中国医学 | 5篇 |
肿瘤学 | 393篇 |
出版年
2024年 | 2篇 |
2023年 | 23篇 |
2022年 | 60篇 |
2021年 | 138篇 |
2020年 | 69篇 |
2019年 | 139篇 |
2018年 | 174篇 |
2017年 | 102篇 |
2016年 | 102篇 |
2015年 | 112篇 |
2014年 | 206篇 |
2013年 | 322篇 |
2012年 | 496篇 |
2011年 | 416篇 |
2010年 | 264篇 |
2009年 | 237篇 |
2008年 | 360篇 |
2007年 | 433篇 |
2006年 | 360篇 |
2005年 | 330篇 |
2004年 | 289篇 |
2003年 | 244篇 |
2002年 | 207篇 |
2001年 | 28篇 |
2000年 | 18篇 |
1999年 | 25篇 |
1998年 | 42篇 |
1997年 | 39篇 |
1996年 | 27篇 |
1995年 | 28篇 |
1994年 | 24篇 |
1993年 | 19篇 |
1992年 | 7篇 |
1991年 | 8篇 |
1990年 | 12篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1977年 | 1篇 |
1953年 | 1篇 |
1948年 | 1篇 |
排序方式: 共有5386条查询结果,搜索用时 9 毫秒
41.
Weimar Kunz Sebba Barroso Andra Araujo Brando Priscila Valverde de Oliveira Vitorino Audes Digenes de Magalhes Feitosa Eduardo Costa Duarte Barbosa Roberto Dischinger Miranda Josep Redon Miguel Camafort-Babkowski Antonio Coca Marco Antnio Mota Gomes 《Arquivos brasileiros de cardiologia》2022,118(6):1069
BackgroundAdequate treatment of arterial hypertension and achieving arterial hypertension goals in are important in reducing cardiovascular outcomes.ObjectivesTo describe angiotensin receptor blockers in monotherapy or double combination therapy and the rate of arterial hypertension control.MethodsThis cross-sectional study evaluated patients who were using angiotensin receptor blockers between 2017 and 2020. Those using three or more antihypertensive drugs were excluded. The analyzed variables included sex, age, body mass index, valid home blood pressure monitoring (HBPM) measurements, casual and HBPM systolic and diastolic blood pressure measurements, blood pressure variability, and antihypertensive and angiotensin receptor blocker class. Paired t, chi-square, and Fisher’s exact tests were used, as well as overlapping 95% confidence intervals and a significance level of 5% (p < 0.05).ResultsOf 17,013 patients, 12,813 met the inclusion criteria, 62.1% of whom were female. The mean number of valid measurements was 23.3 (SD, 2.0). The mean HBPM and casual measurements for systolic blood pressure were 126.8 (SD, 15.8) mmHg and 133.5 (SD, 20.1) mmHg (p <0.001), respectively, while those for diastolic blood pressure were 79.1 (SD, 9.7 mmHg) and 83.6 (SD, 11.9) mmHg (p <0.001), respectively. Losartan was the most common angiotensin receptor blocker and resulted in the highest blood pressure values. Combinations of angiotensin receptor blockers with diuretics or calcium channel antagonists resulted in lower blood pressure values.ConclusionsMore than half of the patients used losartan, although it was the least efficient drug for reducing and controlling blood pressure. 相似文献
42.
43.
Bayés B Lauzurica R Granada ML Serra A Bonet J Fontseré N Salinas I Romero R 《Transplantation》2004,78(1):26-30
BACKGROUND: New-onset diabetes mellitus after transplantation (NODAT) is a severe complication of kidney transplantation (KTx) with negative effects upon patient and graft survival. Several risk factors for NODAT have been described; however, the search for an early predictive marker is ongoing. It has recently been demonstrated that high concentrations of adiponectin (APN), which is an adipocyte-derived peptide with antiinflammatory and insulin-sensitizing properties, protect against future development of type 2 diabetes in healthy individuals. The purpose of this report was to study pretransplant insulin resistance and analyze pretransplant serum leptin and APN levels as independent risk factors for the development of NODAT. METHODS: A total of 68 KTx patients were studied [mean age, 48 +/- 11 years; 70% males; body mass index (BMI), 25 +/- 3 kg/m]; 31 KTx patients with NODAT and 37 KTx patients without NODAT (non-NODAT) with similar age, sex, BMI, immunosuppression, and posttransplant time were studied. All patients received prednisone and calcineurin inhibitors (75% tacrolimus and 25% cyclosporine A), and 76% of patients received mycophenolate mofetil. Family history of diabetes mellitus was recorded. Pretransplant homeostasis model assessment for insulin resistance (HOMA-IR) index was calculated from fasting plasma glucose and insulin. Pretransplant serum leptin and APN levels were determined by radioimmunoassay. RESULTS: NODAT patients showed higher pretransplant plasma insulin concentrations [NODAT, 13.4 (11-22.7) microIU/mL; non-NODAT, 10.05 (7.45-18.4) microIU/mL; P=0.049], HOMA-IR index [NODAT, 4.18 (2.49-5.75); non-NODAT, 2.63 (1.52-4.68); P=0.043], and lower pretransplant serum APN concentration [NODAT, 8.78 (7.2-11.38) microg/mL; non-NODAT, 11.4 (8.56-15.27) microg/mL, P=0.012]. Inverse correlations between APN and BMI (r=-0.33; P=0.014) and APN and HOMA-IR index (r=-0.39; P=0.002) and between APN and NODAT (r=-0.31; P=0.011) were observed. Multiple logistic regression analysis showed the patients with lower pretransplant APN concentrations to be those at greater risk of developing NODAT [Odds Ratio=0.832 (0.71-0.96); P=0.01]. CONCLUSION: Pretransplant serum APN concentration is an independent predictive factor for NODAT development in kidney-transplanted patients. 相似文献
44.
45.
46.
Luis Almenar Bonet Josep Comín Colet Enrique Pérez de la Sota Beatriz Díaz Molina 《Revista espa?ola de cardiología》2012
The mission of the Heart Failure and Heart Transplantation Section of the Spanish Society of Cardiology is to study, promote interest in, and disseminate information about all aspects of myocardial dysfunction and heart transplantation. Heart failure is a highly prevalent disorder that consumes a substantial proportion of healthcare resources. Consequently, there is a very high level of interest in the condition and a wide range of preclinical and clinical research is being carried out, including research into new ways of looking at the disease that will increase our understanding. The aim of this article was to describe current developments concerning this disease and its treatment. Firstly, the latest publications on heart failure are summarized. Then, the most recent studies on advanced heart failure and ventricular assist devices are reviewed. Finally, the latest findings on heart transplantation are reported. 相似文献
47.
Impact of induction treatment before autologous stem cell transplantation on long‐term outcome in patients with newly diagnosed multiple myeloma 下载免费PDF全文
48.
49.
Verónica Vidal Cristina Albiach Josep Gradolí José Leandro Pérez Vicente Montagud Joaquina Belchí Salvador Morell Lorenzo Fácila 《Revista portuguesa de cardiologia》2018,37(8):717.e1-717.e5
Prosthetic valve endocarditis is a major diagnostic challenge in clinical practice, due to the lower sensitivity of the modified Duke criteria and a higher percentage of cases with negative or inconclusive echocardiography results. The delay in establishing medical and surgical treatment increases the morbidity/mortality rate. New imaging techniques and 18F-FDG PET/CT in particular have meant a significant advance in cases of high clinical suspicion and negative or inconclusive echocardiography, increasing the overall sensitivity of the modified Duke criteria.We report the case of a male patient with prosthetic valve endocarditis, where 18F-FDG PET/CT provided the diagnostic key, determining the origin of the endocarditis and avoiding treatment delay. 相似文献
50.
Dafina Petrova Marina Polln Miguel Rodriguez-Barranco Dunia Garrido Josep M. Borrs Maria-Jos Snchez 《British journal of cancer》2021,124(12):2017
Background The patient interval—the time patients wait before consulting their physician after noticing cancer symptoms—contributes to diagnostic delays. We compared anticipated help-seeking times for cancer symptoms and perceived barriers to help-seeking before and after the coronavirus pandemic.Methods Two waves (pre-Coronavirus: February 2020, N = 3269; and post-Coronavirus: August 2020, N = 1500) of the Spanish Onco-barometer population survey were compared. The international ABC instrument was administered. Pre–post comparisons were performed using multiple logistic and Poisson regression models.Results There was a consistent and significant increase in anticipated times to help-seeking for 12 of 13 cancer symptoms, with the largest increases for breast changes (OR = 1.54, 95% CI 1.22–1–96) and unexplained bleeding (OR = 1.50, 1.26–1.79). Respondents were more likely to report barriers to help-seeking in the post wave, most notably worry about what the doctor may find (OR = 1.58, 1.35–1.84) and worry about wasting the doctor’s time (OR = 1.48, 1.25–1.74). Women and older individuals were the most affected.Conclusions Participants reported longer waiting times to help-seeking for cancer symptoms after the pandemic. There is an urgent need for public interventions encouraging people to consult their physicians with symptoms suggestive of cancer and counteracting the main barriers perceived during the pandemic situation.Subject terms: Cancer epidemiology, Cancer screening, Signs and symptoms, Public health, Diagnosis 相似文献