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排序方式: 共有5065条查询结果,搜索用时 15 毫秒
71.
Sancho-Puchades M Vílchez-Pérez MÁ Valmaseda-Castellón E Paredes-García J Berini-Aytés L Gay-Escoda C 《Medicina oral, patología oral y cirugía bucal》2012,17(3):e462-e468
Objective: To compare the anesthetic action of 0.5% bupivacaine in relation to 4% articaine, both with 1:200,000 epinephrine, in the surgical removal of lower third molars. As a secondary objective hemodynamic changes using both anesthetics were analyzed.
Study Design: Triple-blind crossover randomized clinical trial. Eighteen patients underwent bilateral removal of impacted lower third molars using 0.5% bupivacaine or 4% articaine in two different appointments. Preoperative, intraoperative and postoperative variables were recorded. Differences were assessed with McNemar tests and repeated measures ANOVA tests.
Results: Both solutions exhibited similar latency times and intraoperative efficacy. Statistical significant lower pain levels were observed with bupivacaine between the fifth (p=0.011) and the ninth (p=0.007) postoperative hours. Bupivacaine provided significantly longer lasting soft tissue anesthesia (p<0.05). Systolic blood pressure and heart rate values were significantly higher with articaine.
Conclusions: Bupivacaine could be a valid alternative to articaine especially due to its early postoperative pain prevention ability.
Key words:Bupivacaine, articaine, third molar, anesthesia, postoperative pain. 相似文献
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Brunelli L Campagna R Airoldi L Cauli O Llansola M Boix J Felipo V Pastorelli R 《Metabolic brain disease》2012,27(1):37-49
Hepatic encephalopathy (HE) is a neurological disease associated with hepatic dysfunction. Current knowledge suggests that
hyperammonemia, related to liver failure, is a main factor contributing to the cerebral alterations in HE and that hyperammonemia
might impair signal transduction associated with post-translational modification of proteins such as tyrosine-nitration and
phosphorylation. However, the molecular bases of the HE remain unclear and very little is known about the occurrence of post-translational
modification on in vivo proteins. In this exploratory study we look for evidence of post-translation modifications of proteins
in the cerebellum of experimental HE rat models using a proteomic approach. For the first time we showed that hyperammonemia
without liver failure (HA rats) and experimental HE with liver failure due to portacaval shunt (PCS rats) lead to a reduced
protein nitration in rat cerebellum, where the undernitrated proteins were involved in energy metabolism and cytoskeleton
remodelling. Moreover we showed that tyrosine nitration loss of these proteins was not necessarily associated to a change
in their phosphorylation state as result of the disease. Interestingly the rat cerebellum phosphoproteome was mainly perturbed
in PCS rats, whereas HA rats did not shown appreciable changes in their phosphoprotein profile. Since the protein nitration
level decreased similarly in the cerebellum of both HA and PCS rats, this implies that the two disease models share common
effects but also present some differential signalling effects in the cerebellum of the same animals. This study highlights
the interest for studying the concerted action of multiple signalling pathways in HE development. 相似文献
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Sunyer J Garcia-Esteban R Castilla AM Aurrekoetxea JJ I?iguez C Tardón A Espada M Lertxundi A Chatzi L Rebagliato M Kogevinas M;INMA project 《The European respiratory journal》2012,40(2):371-376
Tobacco consumption and exposure to second-hand smoke (SHS) are associated with reduced birth weight. One issue that has not been clarified previously is that of the potential higher risk of this outcome in mothers with asthma. We assessed the role of prenatal maternal tobacco use and SHS on reproductive outcomes and assessed the interaction with maternal history of asthma. Data was collected from the INMA study, a maternal birth cohort selected from the general population established in Spain in 2002. We measured cotinine at the 32nd week of pregnancy in 2,219 females. Diagnosed maternal asthma was self-reported during pregnancy. 35% of mothers reported not being exposed to smoking or SHS during pregnancy. Active smoking (i.e. self-reported or cotinine >50 ng·mL(-1)) was related to a 134 g decrease in birth weight and a relative risk of 1.8 for small for gestational age and fetal growth restriction. These results were not modified by maternal asthma. Maternal asthma had a similar frequency in all exposure groups. Non SHS-exposed females had the lowest prevalence of asthma. SHS (i.e. cotinine 20-50 ng·mL(-1)) decreased birth weight by 32 g among those without maternal asthma, but these differences were not statistically significant (95% CI -88.76-24.76). Maternal asthma did not promote these effects. Maternal history of asthma did not modify the effects of smoking on reproductive outcomes in a cohort sampled from the general population. 相似文献
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