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991.
992.
Thirty-five posters were presented at the Workshop on Brain Uptake And Utilization Of Fatty Acids, Lipids, and Lipoproteins.
They were grouped into four categories: (1) mechanisms of lipid uptake and transport to the brain, (2) lipoproteins and polyunsaturated
fatty acids, (3) eicosanoids in brain function, and (4) fatty acids and lipids in brain disorders. This article summarizes
the highlights of the research presented in these posters. The individual abstracts follow these synopses. 相似文献
993.
994.
995.
Not many data exist to guide us in the management of patients with chronic hepatitis B virus infection and “normal” alanine
aminotransferase levels. Many of these patients may not have normal levels on long-term follow-up or when the upper limit
of normal is determined from a truly healthy reference population. These patients may have significant histologic disease
and benefit from further investigation or treatment. This article focuses on the disease course of such patients. 相似文献
996.
Jens Jordan 《Clinical autonomic research》2007,17(6):331-333
Genes influencing the autonomic nervous system continue as a focus of research. Recent publications applied different methods
to identify genes influencing autonomic cardiovascular regulation in humans. Two reports relied on a candidate gene approach.
Common genetic polymorphisms in the promoter region of the tyrosine hydroxylase gene were shown to influence catecholamine
synthesis and blood pressure. The same group tested the hypothesis that the GTP cyclohydrolase 1 (GCH1) gene influences catecholamine
excretion and cardiovascular regulation. GCH1 affects tyrosine hydroxylase function indirectly. The authors concluded that
the GCH1 gene may influence cardiovascular autonomic regulation through changes in nitric oxide production rather than a change
in tyrosine hydroxylase activity. The third genetic study used a single nucleotide polymorphism chip to analyze 100,000 genetic
polymorphisms scattered throughout the genome in participants of the Framingham study. The authors identified several polymorphisms
that may influence QT interval duration, heart rate, and heart rate variability. The respective genes have not been identified
with certainty. Another study suggested that catecholamines may be released from phagocytes and regulate pulmonary inflammation
through alpha-2 adrenoreceptor activation in an autocrine or paracrine fashion. 相似文献
997.
OBJECTIVE: To investigate the effect of growth hormone (GH) on penile erection after reconstruction of cavernous nerves using sural nerve as an interposition nerve graft in rats. METHODS: Twenty-four male Sprague-Dawley rats (3-4 ms of age and 300-400 g in weight) were randomly divided into 2 groups: nerve graft group and GH group, each electrostimulated to determine the erectile potency 2 and 4 months after nerve graft (followed by hypodermic GH injection). The nNOS-positive nerve fibers in the corpora cavemosa were examined by streptavidin-peroxidase immunohistochemistry technique (SP method). Image analysis was used to calculate the area stained in pixel. RESULTS: Electrostimulation at 2 months produced 31.25% of erections in the GH group but none in the grafted rats. There was a significant difference in the erection rate produced by electrostimulation between the two groups at 2 months (P < 0.05). The pixel of the expression of nNOS-positive nerve fibers in the GH group (38971 +/- 7692) was also greater than that of the graft group (16538 +/- 3179, P < 0.05). At 4 months, 43.75% of the graft group and 75% of the GH group produced erections upon electrostimulation, with no significant difference between the two groups (P > 0.05). The pixels of the expression of nNOS-positive nerve fibers were 79276 +/- 12,021 and 91348 +/- 18965, respectively (P > 0.05). CONCLUSION: GH can accelerate the regeneration of cavernous nerves after bilateral nerve grafting, and GH administration may present a new physiological approach to the treatment of erectile dysfunction after radical pelvic surgery. 相似文献
998.
Intra-observer and inter-observer agreement of the manual examination of the lumbar spine in chronic low-back pain 总被引:1,自引:1,他引:0
Etienne Qvistgaard Jens Rasmussen Jes Lætgaard Steen Hecksher-Sørensen Henning Bliddal 《European spine journal》2007,16(2):277-282
Examination is a cornerstone in the manual procedures leading to mobilisation/manipulation of the low back. The observer variation of the more specific segmental tests remains to be investigated. Two skilled specialists in manual medicine examined the segmental changes in the lumbar spine. The patients were unknown to the examiners and no information of the case history was given. All test results were recorded by an observer present in the room who ensured that no conversation was allowed during the examination. The primary outcome measures were the kappa values for each test. The matching was defined as acceptable (acc) within two neighbouring levels and perfect (per) on the same level. Intra-observer variation (tested in 33 patients and 10 subjects without low-back pain): The agreement between first and second segmental diagnosis examination was 70% (per) and 82% (per + acc). Kappa values were: segmental diagnosis 0.60 (per) and 0.70 (per + acc), multifidus test 0.51 (per) and 0.60 (per + acc), sideflexion 0.57 (per) and 0.69 (per + acc), and ventral flexion 0.31 (per) and 0.45 (per + acc). Inter-observer variation (tested in 60 patients): The agreement for segmental diagnosis between the examiner A and B was 42% (per) and 75% (per + acc). Kappa values were: segmental diagnosis 0.21 (per) and 0.57 (acc), multifidus test 0.12 (per) and 0.48 (acc), sideflexion 0.22 (per) and 0.45 (acc), and ventralflexion 0.22 (per) and 0.44 (acc). By manual tests, skilled examiners seem to be able to diagnose segmental dysfunctions in the low back. The clinical implication of these dysfunctions remains to be clarified. 相似文献
999.
Modic changes following lumbar disc herniation 总被引:4,自引:3,他引:1
Only a small proportion (20%) of patients with LBP can be diagnosed based on a patho-anatomical entity. Therefore, the identification
of relevant subgroups, preferably on a patoanatomical basis, is strongly needed. Modic changes have been described by several
authors as being closely linked with LBP. The aims of this study were to describe the prevalence of Modic changes, their development
as well as their association to LBP, previous disc contour, and surgery in patients with previous severe sciatica. This is
a longitudinal cohort study where the patients were recruited from an RCT comparing two active conservative treatments, the
181 patients, who at baseline had radicular pain in or below the knee; all underwent a physical examination and MRI. MRI’s,
pain history and physical examination of 166 patients were obtained at follow-up 14 months later. The prevalence of Modic
changes type 1 increased from 9% at baseline to 29% at follow-up. At that time, a strong association between Modic changes
and non-specific LBP was noted. Apparently, Modic changes type 1 was more strongly associated with non-specific lumbar pain
than Modic changes type 2. The development of new Modic changes was closely related to the level of a previous disc herniation.
A lumbar disc herniation is a strong risk factor for developing Modic changes (especially type 1) during the following year.
Furthermore, Modic changes are strongly associated with LBP. 相似文献
1000.
The ability to compare various results that measure clinical deficits and outcome is a necessity for successful worldwide
discussion about cervical spondylogenic myelopathy (CSM) and its treatment. There is hardly any information in literature
how to value and compare outcome assessed by different scores. In a retrospective study we objectively evaluated the Nurick-score,
Japanese-orthopaedic-association-score (JOA-Score), Cooper-myelopathy-scale (CMS), Prolo-score and European-myelopathy-score
(EMS) using the data of 43 patients, all of whom showed clinical and morphological signs of CSM and underwent operative decompression.
The scores were assessed pre- and postoperatively. The correlation between the score-results, anamnesis, clinical and diagnostic
data was investigated. All the scores show a statistically significant correlation and measure postoperative improvement.
With exception of the Prolo-score all scores reflect clinical deficits of CSM. The Prolo-score rates the severity of CSM on
the state of the economic situation above clinical symptoms. The main differences of the scores are shown in the number of
patients showing postoperative improvement, varying between 33% (Nurick-score) and 81% (JOA-score). The recovery-rates, as
a measure of the cumulative improvement of all the symptoms, show less variation (23–37%). The differences of the recovery-rate
were only statistically significant between JOA-score, Nurick-score and EMS (P < 0.05), whereas all the other scores showed no significant differences. To assess the postoperative successes, the evaluation
of the recovery-rate is essential. There is no significant difference in the recovery-rate amongst the majority of the scores,
which allows a good comparison of the results from different studies. Nevertheless, it is always important to differentiate
the therapy results of CSM published worldwide. 相似文献